Abstract: Objective To explore the relationship between duration of diabetes mellitus and cerebrovascular disease by observing the variation of transcranial Doppler sonograghy(TCD)in different stages of type 2 diabetes mellitus patients. Methods Eighty type 2 diabetes mellitus patients who were hospitalized or confirmed in the department of our hospital were divided to two groups,40 patients in group A(disease course≥10 years)and 40 patients in group B(disease course ﹤ 10 years). The group C including 40 health persons with similar age served as control group( group C). The systolic peak velocity(VP)and pulsatility index(PI)of middle cerebral artery(MCA)of left and right sides and vertebral artery(VA)of left and right sides in three groups were detected by TCD. Results The VP of MCA of left and right sides and VA of left and right sides of group A and group B were significantly higher than those of group C(P ﹤ 0. 01),the VP of MCA of left and right sides and VA of left and right sides of group A were much higher than those of group B(P ﹤ 0. 01),the PI of MCA of left and right sides and VA of left and right sides of group A were much higher than those of group B and group C(P ﹤ 0. 01), and there were no significant statistic differences between the PI of MCA of left and right side and VA of left and right side of group B and group C(P ﹥ 0. 05). Conclusion The cerebrovascular disease may be related to disease course of diabetes mellitus patients and TCD test can provide important information in functional status of cerebral blood vessels.

Key words: diabetes mellitus, type 2, cerebrovascular trauma, ultrasonography, Doppler