Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the clinical value of procalcitonin(PCT) and Creactive protein(CRP) for discrimination between tumor fever and infectious fever in nonsmall cell lung cancer patients.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓In our study, we retrospectively analyzed the levels of PCT and CRP in patients with nonsmall cell lung cancer and fever to the hospital, and the febrile patients with nonneutropenia were entrolled. The 96 patients were classified into three groups: 21 patients with bloodstream infection (BSI), 49 patients with localized bacterial infection (LBI), 26 patients with tumor fever (TF). The diagnostic values of PCT and CRP were analyzed for each group.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The study found that the PCT level and PCT/CRP ratio were significantly higher in BSI group and LBI group than in TF group. The patients with bloodstream infection had significantly higher CRP level than those with tumor fever, however, there was no statistical difference in patients with localized bacterial infection and tumor fever. PCT/CRP was the best test for discriminating tumor fever and infectious fever in terms of the area under the curve of the ROC curve. To discriminate between tumor fever and localized bacterial infection, at the cutoff of 0.005 5 for PCT/CRP, the sensitivity and specificity of PCT/CRP were 81.6% and 96.2%. To discriminate between tumor fever and bloodstream infection, at the cutoff of 0.005 0 for PCT/CRP, the sensitivity and specificity of PCT/CRP were 90.5% and 92.3%.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The PCT level and PCT/CRP ratio were more useful parameters than CRP level for discriminating patients with tumor fever and infectious fever. Furthermore, PCT/CRP ratio was the best marker for discrimination between tumor fever and infectious fever.

Key words: lung neoplasms； fever； procalcitonin, Creactive protein