Abstract: ［Abstract］ Objective〖HTSS〗To analyze the risk factors of adjacent vertebral compression fractures after percutaneous vertebroplasty and percutaneous kyphoplasty ,and to explore the main causes of re-fracture.
〖HTH〗〖WTHZ〗Methods〖HTSS〗A retrospective analysis of 176 patients undergoing surgical treatment was divided into group A(fracture group, 21 cases) and group B(control group, 155 cases，including 3 cases of surgical vertebral fractures, 2 cases of jumping vertebral fractures, and 150 cases without fractures). Age, gender, surgical approach，puncture method, BMI, preoperative bone mineral density, bone cement injection, bone cement leakage, anti-osteoporosis treatment and imbalance of the sagittal plane of the spine were recorded and compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗There was no significant difference between group A and group B in sex, age, amount of bone cement injection and whether bone cement leakage occurred(P＞0.05), but there was significant difference in anti-osteoporosis and spinal sagittal imbalance between two groups(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗Preoperative bone mineral density,sagittal imbalance of the spine are the risk factors for the occurrence of secondary vertebral compression fractures after PVP/PKP, but there is no significant correlation with age, gender, surgical approach，puncture method, BMI, bone cement injection, bone cement leakage. Patients with active anti-osteoporosis treatment can significantly reduce the incidence of adjacent vertebral body fractures.

Key words: spinal fractures, vertebroplasty, secondary fracture, risk factors