Abstract: ［Abstract］ObjectiveTo investigate the correlation between Helicobacter pylori(H.pylori) infection and the expression of cell cycle regulator p27 protein in gastric cancer tissues in order to understand the pathogenesis of gastric cancer caused by H.pylori infection.
〖WTHZ〗MethodsSixty-two specimens of gastric cancer tissues undergoing gastric cancer resection were selected. The 14C-urease breath test was used to detect H.pylori infection in the specimens, and the immunohistochemical staining method was applied to measure the expression level of p27 protein, so as to analyze the correlation between H.pylori infection and p27 expression in gastric cancer patients.
〖WTHZ〗Results Forty cases in 62 patients with gastric cancer were infected by H.pylori(64.52%). The expression rate of p27 protein in gastric cancer tissues was closely related to the degree of tumor differentiation(P＜0.01), there was no correlation between the expression rate of p27 protein and the gender, age, tumor size, and TNM stage, tumor invasion depth and lymph node metastasis(P＞0.05). H.pylori infection was negatively correlated with p27 protein expression in gastric cancer tissues(P＜0.01). Logistics analysis showed the degree of tumor differentiation was the main factor of positive expression of p27 protein in cancer tissues(P＜0.01). Expression of p27 in gastric cancer tissues was lower than in paracaner tissues(P＜0.01).
〖WTHZ〗ConclusionThere is a certain correlation between H.pylori infection and the expression level of p27 protein in gastric cancer patients. H.pylori infection may cause gastric mucosal canceration by reducing the expression level of p27 protein, and p27 protein can be used for the clinical diagnosis of gastric cancer and the determination of whether it is associated with H.pylori infection. p27 protein is also an important indicator to the later diagnosis, treatment and prognosis evaluation of gastric cancer.

Key words: gastric cancer, Helicobacter pylori, p27 protein