Abstract: Objective To explore the value of microRNA-145(miR-145), ABCD2 scores(age, blood pressure, clinical features, duration of symptoms, diabetes) combined with arterial ultrasound in the risk assessment of patients with transient ischemic attack(TIA) progressing to cerebral infarction(CI). 
Methods A total of 132 TIA patients were selected from Department of Neurology of our hospital. According to presence or absence of progression to CI, patients were divided into non-TIA progression to CI group(non-progression group, n=76) and TIA progression to CI group(progression group, n=56). In addition, the two groups were all evaluated by miR-145, ABCD2 score and miR-145+abcd2+ artery ultrasound. ABCD2 score of the two groups was compared; the miR-145 was detected by PT-PCR, and fibrinogen(FIB), hypersensitive C-reactive protein(hs-CRP), and low-density lipoprootein cholesterol(LDL-C) were compared by enzyme-linked immunoabsorbent assay. The detection rate, missed diagnosis, misdiagnosis rate and diagnostic efficiency of the three methods were compared. 
Results Compared with non-progression group, the ABCD2 score increased and the expression of miR-145 decreased in progression group(P＜0.05); FIB and LDL-C levels decreased and hs-CRP levels increased(P＜0.05). Compared with the detection of miR-145 and ABCD2 score, the detection rate of miR-145+ABCD2 score + arterial ultrasound increased in patients with TIA progressing to CI(P＜0.05). Compared with the detection rate of miR-145 and ABCD2 score, the misdiagnosis rate and missed diagnosis rate of the miR-145+ABCD2 score+arterial ultrasound test decreased(P＜0.05). The sensitivity, specificity and accuracy of the miR-145+ABCD2 score+arterial ultrasound test increased compared with the detection of the miR-145 and ABCD2 scores(P＜0.05). 
Conclusion The use of miR-145, ABCD2 score combined with arterial ultrasound to detect patients with CI after TIA attack has a high detection rate and sensitivity, and has a high value for risk assessment of CI after TIA attack, which is worthy of clinical popularization. 

Key words: ischemic attack, transient, ultrasonography