Abstract: Objective To investigate the influencing factors of hyperuricemia(HUA)in patients with type 2 diabetes mellitus(T2DM)treated with single oral antidiabetic drug. 
Methods A total of 912 patients taking single oral antidiabetic drug in the Department of Endocrinology, Qinhuangdao Military Hospital were selected and divided into normal uric acid group(NUA group, n=741) and HUA group(n=171)according to SUA level. The indexes of glucose and lipid metabolism and the use of oral antidiabetic drug were compared in each group, and the influencing factors of HUA in T2DM patients were analyzed. 
Results The incidence of HUA in T2DM patients was 18.8%(171/912). Compared with NUA group, the level of total cholesterol(TC) in HUA group was higher, the proportion of male, family history of HUA, and the use of Gliquidone were increased(P＜0.05 or P＜0.001), and the proportion of using Dapagliflozin was lower(P＜0.001). Multivariate Logistic regression analysis showed that the use of Dapagliflozin(OR=0.414, 95%CI: 0.205-0.848) was the protective factor of HUA in T2DM patients, while male(OR=2.033, 95%CI: 1.054-3.921) and family history of HUA(OR=9.631, 95%CI: 4.113-22.452) were risk factors for HUA in T2DM patients. 
Conclusion The T2DM patients with HUA treated with single oral antidiabetic drug may be related to their male gender and family history of HUA, and may have a higher level of TC. The use of Dapagliflozin may reduce the risk of HUA in such patients.

Key words: diabetes mellitus, type 2, Hyperuricemia, risk factors