Abstract: Objective  To investigate the association between SLC16A11 and SLC16A13 genes and hepatitis B-related liver cancer.  
Methods  In total, 1 039 inpatients and physical examinees were selected from the First Hospital of Hebei Medical University, the Second Hospital of Hebei Medical University, the Fourth Hospital of Hebei Medical University and the Fifth Hospital of Shijiazhuang City, Hebei Province. Among them, 421 patients with hepatitis B-related liver cancer were selected as case group, and 370 healthy people and 248 with natural clearance of HBV as the control group. The association between SLC16A11, SLC16A13 gene polymorphisms and hepatitis B-related liver cancer was analyzed and the odds ratio was calculated by using statistical analysis methods such as χ2 test and binary logistic regression analysis. 
Results  The population with natural clearance of HBV served as controls. When compared with AA genotype, the AG genotype of the SLC16A13 rs4796576 gene could significantly increase the risk of cancer (OR=1.544, 95%CI：1.073-2.224). Compared with the C allele, the dominant model carrying the G allele of the SLC16A13 rs4796576 gene also significantly increased the risk of cancer (OR=1.530, 95%CI：1.079-2.170). 
Conclusion  Compared with the population with naturally clearance of HBV, the SLC16A13 rs4796576 gene polymorphisms is related to hepatitis B-related liver cancer.

Key words: liver neoplasms, hepatitis B, single nucleotide, gene polymorphism