Journal of Hebei Medical University ›› 2024, Vol. 45 ›› Issue (10): 1181-1187.doi: 10.3969/j.issn.1007-3205.2024.10.009

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The predictive value of cuproptosis-related gene lipoyltransferase 1 on postoperative recurrence in patients with CNLC stage Ⅰa hepatocellular carcinoma

  

  1. 1.Department of Hepatobiliary Surgery, the Fourth Hospital of Hebei Medical University， Shijiazhuang 
    0500011 China; 2.Department of General Medicine, the Fourth Hospital of Hebei Medical 
    University, Shijiazhuang 050011, China; 3.Department of Pathology, the Fourth 
    Hospital of Hebei Medical University, Shijiazhuang 050011, China

  • Online:2024-10-25 Published:2024-10-15

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Abstract: Objective To investigate the expression and significance of cuproptosis-related gene lipoyltransferase 1 (LIPT1) in patients with China liver cancer staging (CNLC) Ⅰa hepatocellular carcinoma (HCC) and to construct a LIPT1-related nomogram to predict the risk of postoperative recurrence in these patients. 
Methods Clinical data of 139 CNLC Ⅰa HCC patients who underwent radical surgery at the Fourth Hospital of Hebei Medical University were collected. Immunohistochemistry was used to detect LIPT1 expression in tumor tissues. Survival analysis was performed using the Kaplan-Meier method, and the Cox proportional hazards model was employed to evaluate factors affecting disease-free survival (DFS). A prediction model for DFS was established based on multivariate Cox regression analysis results and validated using calibration curves and time-dependent area under the receiver operating characteristic (ROC) curve. 
Results The 1-year, 3-year, and 5-year DFS rates of 139 CNLC Ⅰa HCC patients were 76.3%, 56.1%, and 46.5%, respectively. Among these patients, 89 had high LIPT1 expression, and 50 had low LIPT1 expression. Multivariate Cox regression analysis revealed that LIPT1 expression (HR=1.093, 95%CI: 1.001-1.193) and history of diabetes (HR=2.172, 95%CI: 1.126-4.191) were independent risk factors for DFS of CNLC Ⅰa HCC patients. The DFS prediction model constructed based on the above indicators showed good consistency. The time-dependent area under the ROC curve of the nomogram for 1-year, 3-year, and 5-year DFS was 0.785, 0.780， 0.766, respectively, and 0.712, 0.794， 0.716, respectively, which were higher than those for tumor size. 
Conclusion LIPT1 can serve as an effective marker to predict postoperative recurrence in CNLC Ia HCC patients. Compared with the traditional indicator tumor size, the nomogram has higher efficacy in predicting DFS of CNLC Ⅰa HCC patients, providing a new direction for postoperative monitoring and individualized treatment of early-stage liver cancer. 


Key words: liver neoplasms, lipoyltransferase 1, prognosis