Abstract: Objective  To explore the clinical effects of immune-enhancing enteral nutrition combined with minimally invasive abdominal drainage on patients with severe acute pancreatitis(SAP). 
Methods  The clinical data of 136 patients with SAP were retrospectively analyzed. The patients were given routine comprehensive treatment measures including minimally invasive abdominal drainage. The patients were divided into control group(n=62, given ordinary enteral nutrition therapy) and combined group(n=74, given immune-enhancing enteral nutrition regimen) according to different enteral nutrition methods. The serum nutritional indicators［albumin(Alb), prealbumin(PA), transferrin(Tf)］ and serum humoral immune indexes［immunoglobulin(Ig) A, IgG, IgM］ were compared between two groups before treatment and after 7 d of treatment. The 7 d and 30 d mortality rates and basic rehabilitation indicators were compared between two groups. 
Results  There was no significant differences in the 7 d mortality rate between two groups(P＞0.05). The 30 d mortality rate  in combined group was significantly lower than those in control group(P＜0.05). After 7 d of treatment, the levels of serum Alb, PA, Tf, IgA, IgG and IgM in two groups were significantly higher than those before treatment, and the levels of serum Alb, PA, Tf, IgA, IgG and IgM in combined group were significantly higher than those in control group(P＜0.05). The feeding recovery time, drainage time, intensive care unit(ICU) stay and hospital stay in combined group were significantly shorter than those in control group(P＜0.05). 
Conclusion  Immune-enhancing enteral nutrition combined with minimally invasive abdominal drainage has prominent effects in the treatment of SAP, and it is beneficial to improve the survival rate and accelerate the recovery of body.

Key words: pancreatitis, enteral nutrition, drainage