Journal of Hebei Medical University ›› 2024, Vol. 45 ›› Issue (6): 724-728.doi: 10.3969/j.issn.1007-3205.2024.06.017

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Correlation between homocysteine and visceral fat obesity in middle-aged and elderly inpatients

  

  1. 1.Department of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China; 
    2.Department of Geriatrics, Xuanwu Hospital of Capital Medical University/National 
    Clinical Research Center for Geriatric Disease, Beijing 100053, China

  • Online:2024-06-25 Published:2024-06-25

Abstract: Objective To investigate the effect of homocysteine (Hcy) on visceral fat obesity (VFO) in middle-aged and elderly inpatients. 
Methods In total, 354 patients admitted to Department of Geriatrics, Xuanwu Hospital were consecutively selected. The clinical and laboratory examination data, and estimated visceral fat area (eVFA) were collected. The patients were divided into VFO group (n=252) and non-VFO group (n=102) according to presence of combined VFO. The effects of Hcy on VFO in middle-aged and elderly inpatients were investigated by cross-sectional study. 
Results Body mass index (BMI) and Hcy were significantly higher in VFO group than in non-VFO group (P<0.05). Binary Logistic regression analysis showed that gender, BMI and Hcy were risk factors for VFO (P<0.05). Spearman correlation analysis showed that Hcy was positively correlated with eVFA (r=0.255, P<0.001) and there was still a correlation after adjusting for age. Stratified by BMI, Hcy was positively correlated with eVFA in the normal weight group (r=0.356, P=0.001) and overweight group (r=0.255, P<0.001), even after adjusting for age. Receiver operating characteristic (ROC) curve analysis displayed that the cut-off value of Hcy was 11.05, with a sensitivity of 86%, and a specificity of 42% [the area under the ROC curve (AUC)=0.646, 95%CI: 0.572-0.719, P<0.001]. 
Conclusion Hcy is positively related with eVFA, and Hcy is a risk factor for VFO. Therefore, Hcy levels should be more tightly controlled in middle-aged and elderly inpatients. 


Key words: obesity, abdominal, homocysteine, visceral fat area