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Table of Content

    25 May 2018, Volume 39 Issue 6
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    Effects of resveratrol on cognitive function and synaptic plasticity in rats with vascular dementia
    LI Qingyun, XU Xiaolin*
    2018, 38(6):  623-627.  doi:10.3969/j.issn.10073205.2018.06.002
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    ［Abstract］ Objective〖HTSS〗〓To observe the effect of resveratrol on the cognitive function of rats with vascular dementia(VD) and to explore its influence on synaptic plasticity.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Fortyfive SD rats were randomly divided into 3 groups: the control group, the VD group and the treatment group, 15 for each group. The VD rats (rats in the VD group and the treatment group) were established by bilateral common carotid artery occlusion. The rats in the treatment group received resveratrol treatment after modeling. Cognitive function was tested by the Morris water maze experiment. The expression of synaptic plasticity associated proteins(PSD95,SYN) in hippocampus of rats were detected by Western blot method.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓Compared with the rats in the control group, the cognitive function of rats in the VD group was decreased, and the expression of the hippocampus PSD95 and SYN was significantly reduced(P＜005). Compared with the rats in the VD group, the cognitive function of rats in the VD group was increased, and the expression of the hippocampus PSD95 and SYN was significantly increased(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Resveratrol treatment could improve the spatial cognitive ability of VD rats significantly. The mechanism of its neuroprotective effect may be closely related to the improvement of impaired synaptic plasticity.
    Expression and clinical significance of HIF1α and Vimentin in nonsmall cell lung cancer#br#
    ZHANG Hongzhen1, YANG Shengjun2， ZANG Yuqin3， LIU Miaomiao1， DUAN Guochen4*
    2018, 38(6):  628-631,635.  doi:10.3969/j.issn.10073205.2018.06.003
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    ［Abstract］ Objective〖HTSS〗〓To investigate the expression of HIF1α and Vimentin in nonsmall cell lung cancer(NSCLC) and its relationship with clinicopathological features.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The expression of HIF1α and Vimentin in nonsmall cell lung cancer tissues and paracancerous tissues was detected by immunohistochemical streptavidinperoxidaselinked method to analyze the relationship between clinical and pathological features.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive rates of HIF1α and Vimentin in nonsmall cell lung cancer were 80.0%(48/60) and 66.7%(40/60), respectively, which were significantly higher than those in paracancerous tissues 5.0%(1/20) and 10.0%(2/20) , the difference was statistically significant(P＜005). The expression of HIF1α was significantly higher in NSCLC tissues with low undifferentiated and high TNM stages(P＜005). The expression of Vimentin was significantly higher in NSCLC tissues with high TNM staging and lymph node metastasis(P＜005). There was a positive correlation between the expression of HIF1α and Vimentin in NSCLC tissues(rs=0354, P=0.006).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The overexpression of HIF1α and Vimentin is closely related to the progression of nonsmall cell lung cancer. The combined detection of HIF1α and Vimentin can be used as a prognostic indicator of nonsmall cell lung cancer.
    Protective effect of calcium  dobesilate on tobramycininduced nephrotoxicity in rats#br#
    LI Yanjun， FENG Yanjing， MENG Jing， WANG Liang*
    2018, 38(6):  632-635.  doi:10.3969/j.issn.10073205.2018.06.004
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    ［Abstract］〓Objective〖HTSS〗〓To investigate the protective effect of calcium dobesilate on tobramycininduced nephrotoxicity.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirty male SpragueDawley rats were randomly divided into three groups. The control group were injected with the normal saline（3 mL·kg-1·d-1）for 7 d. The model were injected with tobramycin(140 mg·kg-1·d-1) for 7 d. The prevention group were injected with tobramycin(140 mg·kg-1·d-1) plus received calcium dobesilate(100 mg·kg-1·d-1) for 7 d. NacetylβDglucosaminidase(NAG), serum creatinine（SCr） and blood urea nitrogen(BUN)concentrations were monitored. Superoxide dismutase（SOD） and malondialdehyde(MDA) were measured to assess the level of oxidative stress in renal tissue samples.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The urinary NAG, SCr, BUN and MDA levels were significantly higher in the model group and the prevention group than that in the control group,and the SOD level of the renal cortex homogenate was significantly lower than that in the control group(P＜0.05). The urinary NAG, SCr, BUN and MDA levels were significantly lower in the prevention group than that in the model group, and the level of SOD of the renal cortex homogenate was significantly higher than in the model group(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Calcium dobesilate is capable of protecting rats against tobramycininduced nephrotoxicity.
    Investigation on the status of depression and anxiety among medical college students#br#
    FENG Fenglian1, WANG Chunyang1, WANG Yuran1, HU Suwan1, SHI Haishui2*
    2018, 38(6):  636-639,644.  doi:10.3969/j.issn.10073205.2018.06.005
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    ［Abstract］ Objective〖HTSS〗〓To provide scientific evidence for medical college students and workers doing psychological guidance, by doing a survey about the emotion of anxiety and depression in medical students.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The emotion status of anxiety and depression and the related influencing factors were investigated and analyzed in 900 students in a medical university using Selfrating Anxiety Scale(SAS) and Selfrating Depression Scale(SDS).
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The results showed that the detection rate of anxiety and depression in medical college students was 12.94%(104/804) and 19.53%(157/804) respectively. There was statistically significant difference in the anxiety detection rate and SDS standard score(both P＜005) between the male and female groups. The SAS score, anxiety detection rate, SDS score and depression detection rate of the professional satisfaction group were all lower than that of the professional unsatisfied group, and the difference was all statistically significant(P＜005). The SAS score, anxiety detection rate, SDS score and depression detection rate of the career satisfaction group were all lower than that of the career unsatisfied group, and the difference was statistically significant(P＜005). The SAS score and anxiety detection rate of the learning environment satisfaction group were lower than that of the learning environment unsatisfied group, and the SDS score and depression detection rate were lower than those of the learning environment dissatisfaction group, and all the difference was statistically significant(P＜005). The learning environment, employment prospects satisfaction and gender have an effect on anxiety in medical college students(t=-4.776, -3.141, 2.549, P＜0.05). The study environment, job prospects satisfaction, and grade had an impact on depression in college students(t=-5.457, -3.571, 2.693, P＜0.05).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The emotional state of medical college students is considerable well. Employment prospects and learning environment satisfaction are associated with the occurrence of anxiety and depression of medical college students.
    Analysis of perioperative period and risk factors of liver failure in patients with hepatitis B virusassociated liver cancer with or without liver cirrhosis#br#
    CHEN Ruijun， XUE Mei， GAO Yanling， LI Chuyun
    2018, 38(6):  640-644.  doi:10.3969/j.issn.10073205.2018.06.006
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    ［Abstract］ Objective〖HTSS〗〓To investigate the perioperative condition and risk factors of liver failure in patients with hepatitis B virusassociated liver cancer with or without liver cirrhosis.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Retrospective study was used to collect 160 cases of HBCC patients hospitalized in our hospital, including 90 cases of liver cirrhosis and 70 cases without cirrhosis. The intraoperative and postoperative conditions of the 2 groups were compared, and the risk factors for postoperative liver failure were analyzed.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓Compared with the control group, the amount of bleeding was more in the study group and the operation time was longer, the difference was statistically significant(P＜005). The blood transfusion rate and the occlusion rate of the hepatic portal in the study group were slightly higher, but the difference was not statistically significant(P＞005). There was no significant difference in the incidence of perioperative pulmonary complications, abdominal infection, biliary fistula and liver failure between the 2 groups(P＞005). Liver failure is a dependent variable, while sex, age, albumin, aspartate aminotransferase, alanine aminotransferase, total bilirubin, prothrombin time activity, ChildPugh classification, operation time, intraoperative bleeding, blood transfusion, liver resection range, tumor diameter, hepatic portal blockage, cirrhosis being independent variables were analyzed by multiple factor Logistic regression analysis. The results showed that age，ChildPugh classification, intraoperative bleeding, blood transfusion, liver resection were found. Risk factors for liver failure in patients with hepatitis B and liver cancer during perioperative period were excluded.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Liver failure is an independent risk factor for liver failure during the perioperative period of liver cirrhosis in patients with hepatitis B, and the risk of perioperative liver failure in patients with liver cancer and liver cirrhosis is higher than that of patients without liver cirrhosis.
    Effect of team management on chronic disease in patients with chronic hypertension#br#
    WANG Li1， WANG Tianyi2， WEN Xiaohua1*， LIU Yanru1， HU Xingmao3， GAO Mian1
    2018, 38(6):  645-648,652.  doi:10.3969/j.issn.10073205.2018.06.007
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    ［Abstract］ Objective〖HTSS〗〓To study the effect of chronic disease team management in patients with chronic hypertension.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One Hundred and four patients with hypertension as a chronic disease were divided into the study group and the conventional group with 52 cases in each group by using the random number table method. The chronic disease team management mode was used for the study group and the conventional management mode was used for the conventional group. We compared the management effects of the two different management modes on patients with hypertension as a chronic disease.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓After management, the patients in the study group had higher data about the understanding and mastery of related knowledge, alcohol abstinence, standardized body weight, diet awareness rate and standardized diet, and had fewer smokers compared those in the two groups before management and those in the conventional group, the difference was statistically significant(P＜005). The difference of the systolic and diastolic blood pressures of patients in the 2 groups before management were not statistically significant(P＞005). After management, the patients in the 2 groups had significantly lower systolic and diastolic blood pressures compared to those before management （P＜005）. After management the systolic and diastolic blood pressure of patients in the study group were significantly lower than those before management(P＜005). By comparing the quality of life of patients in the two groups after management, we found that the score of the quality of life(including physiology, mentality, social relations and environment ) in the study group was higher than that of the conventional group(P＜005). We compared the incidences of complications in the two groups after management. The incidence of complications in the two group were 3.85% and 19.23% respectively, and the study group had significantly lower incidence of complications as compared with the conventional group(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓For patients with hypertension as a chronic diseases, the implementation of the team management mode can not only promote patients with hypertension to master health knowledge, but also can change the patients lifestyle and eating habits, at the same time, the mode can also control the change of blood pressure of patients, improve the quality of life of patients, and especially reduce the incidence of complications. So it should be widely used in clinical practice.
    Effects of allopurinol on serum uric acid and urinary protein excretion of diabetic nephropathy patients with hyperuricemia#br#
    HE Lifang1, YAN Shuanghuan2, LI Hongshan3， WANG Dongmei1, REN Pingxiang1
    2018, 38(6):  649-652.  doi:10.3969/j.issn.10073205.2018.06.008
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    ［Abstract］〓Objective〖HTSS〗〓To observe the effects of allopurinol on serum uric acid(SUA) and urinary protein excretion of diabetic nephropathy(DN) patients with hyperuricemia.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and sixty DN patients with hyperuricemia were included in this study. They were randomly divided into control group(80 cases) and allopurinol group(80 cases). Two groups of patients were given the conventional treatment of diabetes. The control group were given placebo and the treatment group were given allopurinol. 24 hour urine protein quantitative(UTP), urinary albumin excretion rate（UAER）, SUA， highsensitivity Creactive protein(hsCRP), potassium， serum creatinine(SCr)， blood glucose were detected before and after treatment. 
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓UTP, UAER, hsCRP, SUA of the patients in the two groups after treatment were decreased, and  UTP, UAER, hsCRP and SUA in treatment group were lower than those in control group, the difference was statistically significant（P＜005）. After treatment, there was no significant difference in the SCr, potassium and GLU between 2 groups and the 2 groups before and after treatment（P＞005）.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Allopurinol can effectively reduce urinary albumin excretion rate in diabetic nephropathy patients with hyperuricemia. The mechanism may be related to reduce urinary protein excretion through the effects of uric acid and insulin resistance, so as to protect renal function early.
    Effect of PEEP on intracranial pressure in patients with poorgrade aneurysmal subarachnoid hemorrhage and severe respiratory dysfunction#br#
    YANG Lei1, ZHANG Dongliang1, HAN Yongfeng1, LI Conghui1, SONG He2, ZHANG Shiyang3*
    2018, 38(6):  653-657,661.  doi:10.3969/j.issn.10073205.2018.06.009
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    ［Abstract］ Objective〖HTSS〗〓To investigate the effect of endexpiratory positive pressure on intracranial pressure in patients with poorgrade aneurysmal subarachnoid hemorrhage and severe respiratory dysfunction.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thrity  cases of poorgrade aneurysmal subarachnoid hemorrhage combined with severe respiratory dysfunction were divided into 19 cases with neurogenic pulmonary edema and 11 cases without neurogenic pulmonary edema group. PEEP was set up to 0 cmH2O, 6 cmH2O and 12 cmH2O to observe the changes of vital signs and intracranial pressure.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓When PEEP was 12 cmH2O, the intracranial pressure and central venous pressure were significantly higher than that of PEEP 0 cmH2O and PEEP 6 cmH2O. When PEEP was 12 cmH2O, the cerebral perfusion pressure was significantly lower than that of 0 cmH2O. There were statistically significant differences(P＜005). There was no significant difference in intracranial pressure, cerebral perfusion pressure and central venous pressure between the two groups at different end expiratory pressure(P＞005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Poorgrade aneurysmal subarachnoid hemorrhage combined with severe respiratory dysfunction in patients with severe respiratory dysfunction can significantly increase intracranial pressure and decrease cerebral perfusion after＞12 cmH2O, which is not related to the occurrence of neurogenic pulmonary edema.
    Clinical study of 3DSlicer assisted positioning minimally invasive soft channel surgery in the treatment of hypertensive intracerebral hemorrhage in the elderly
    XU Guangtao1, ZHAO Zongmao2,3*, KONG Yabo1, WANG Jiangying1, DU Juan1
    2018, 38(6):  658-661.  doi:10.3969/j.issn.10073205.2018.06.010
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    ［Abstract］〓Objective〖HTSS〗〓To explore the clinical effect of 3DSlicer assisted positioning minimally invasive soft channel surgery in the treatment of aged hypertensive cerebral hemorrhage.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The clinical data of 113 patients with hypertension cerebral hemorrhage was analyzed retrospectively, including 53 patients with soft channel minimally invasive surgery by 3DSlicer auxiliary positioning(surgical group), 60 patients with nonsurgical treatment(non surgical group). The patients of two groups were followed up for 5 weeks, and the time of removal of hematoma, neurological impairment and the mortality rate were compared.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The time of hematoma removal of the surgical group was obviously lower than the non surgical group(P＜005). National Institute of Health Stroke Scale(NIHSS) scores were all decreased compared with the admission, which the NIHSS scores and the mortality rate of the surgical group were both significantly declined than non surgical group(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Soft channel technology with 3DSlicer auxiliary positioning has a good clinical effect in the treatment on elderly hypertensive intracerebral hemorrhage with a medium dose, which shortened the time of hematoma removal and lowered the mortality rate.
    miR32 affects proliferation of osteosarcoma cells by regulating PI3K/Akt signaling pathway#br#
    LIU Chunjie1， LIU Yu2， DENG Xuekun3， WANG Juntong1， ZHANG Yueming1， ZHANG Yigeng1
    2018, 38(6):  662-667.  doi:10.3969/j.issn.10073205.2018.06.011
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    ［Abstract］ Objective〖HTSS〗〓To find out the function and mechanism of microRNA32（miR32） in osteosarcoma cell proliferation.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Reverse transcriptionpolymerase chain reaction（RTPCR） was used to detect the expression of miR32 in osteosarcoma tissues, normal tissues and different cell lines. The effect of inhibiting miR32 expression on the proliferation rate of human osteosarcoma MG63 cell line was detected by CCK8. Luciferase assay showed that miR32 could bind specifically to the 3′UTR of phosphatase and tensin homolog deleted on chromosome ten（PTEN） gene. At the same time, RTPCR and western blotting were used to verify the relationship between miR32 and PTEN from RNA and protein level respectively.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓miR32 in 〖JP2〗osteosarcoma tissues and cells activate PI3K/Akt signaling pathway after binding to PTEN′s〖JP〗 3′UTR, which further influences the proliferation of MG63 cells. 
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓miR32 regulates the proliferation of osteosarcoma cells through PI3K/Akt signaling pathway.
    Analysis of prognostic factors of infantile hip joint suppurative arthritis#br#
    CUI Yingtie, ZHANG Fang*, FENG Yanhua, HAO Jianzong, HE Mingzhe, ZHEN Lei
    2018, 38(6):  668-671,676.  doi:10.3969/j.issn.10073205.2018.06.012
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    ［Abstract］ Objective〖HTSS〗〓To investigate the influencing factors of sequelae of septic arthritis of the hip in infants and to provide a clinical basis for prevention and evaluation of prognosis.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The data of 45 children with septic arthritis of the hip were collected and analyzed retrospectively. All children were infants within 6 months with an average age of(1.97±1.67) month. Factors such as gender, age, hip side, delayed treatment time, proximal femoral osteomyelitis, bacterial species, and ChiSquare Test were used for univariate analysis of each factors, Logistc regression was used for multivariate analysis based on factors that may influence the prognosis.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The 38 patients were followed up, and 13 cases had sequelae of septic arthrit of the hip, 25 cases didn't have, and the sequelae rate was 34.2%. 92.3%(12 cases) of the infants with sequelae of septic arthritis of the hip are less than 2 months old, 61.5%(8 cases)of the time of diagnosis were longer than 7 days, and all the infants with proximal femoral osteomyelitis had sequelae of septic arthritis of the hip. In addition, there was a significant difference between infants with sequelae and those with no sequelae in age, the time of diagnosis and proximal femoral osteomyelitis. The multivariate Logistc regression showed that age, delayed treatment time, proximal femoral osteomyelitis were significantly associated with the incidence of sequelae of hip of septic arthritis(P＜0.05).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Septic arthritis of the hip has a high rate of sequelae on infant, and its prognosis is related to age, delayed treatment time, and proximal femoral osteomyelitis. The incidence of sequelae of hip of septic arthritis in neonates and infants less than two month is significantly increased. Generally, within a week, diagnosis and reasonable treatment can reduce the occurrence of sequelae.
    Clinical study of anterior and posterior surgical treatment for thoracolumbar burst fractures#br#
    LI Bingnan, HU Guijun, ZHENG Hai, WU Rong, LIN Zhenjun, LI Kuimeng
    2018, 38(6):  672-676.  doi:10.3969/j.issn.10073205.2018.06.013
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    ［Abstract］〓Objective〖HTSS〗〓To explore the clinical effect of the anterior and posterior surgical approach in the treatment of thoracolumbar burst fracture.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 60 patients with thoracolumbar burst fracture who were admitted in our hospital from March, 2015 to February, 2016 were included in the study and divided into the anterior group and posterior group with 30 cases in each group according to different surgical methods. The patients in the anterior group were given internal fixation, while the patients in the posterior group were given pedicle screw system treatment. The operation time, blood loss, drainage volume, and total fusion time were recorded. CT was used to measure the anteroposterior diameter and crosssectional area of spinal canal before operation, 1 week and 1 year after operation. Cobb′s angle change value before operation, immediately after operation, and 1 year after operation was observed. American Spinal Injury Association（ASIA） was used to evaluate the neurological function recovery 1 year after operation.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The intraoperative blood loss and postoperative drainage volume in the anterior group were significantly greater than those in the posterior group, while the operation time and fusion time were significantly longer than those in the posterior group(P＜005). The spinal canal stenosis degree 1 week and 1 year after operation in the two groups was significantly improved when compared with before operation(P＜005). The comparison of spinal canal stenosis 1 week after operation between the two groups was not statistically significant(P＞005). The recovery of spinal canal stenosis 1 year after operation in the anterior group was significantly superior to that in the posterior group(P＜005)，there was a statistically significant in the interactions between groups, time points, groups and time points. Cobb′s angle after opeation in the two groups was significantly reduced when compared with before operation(P＜005)， there was a statistically significant in the interactions between groups, time points, groups and time points. Cobb′s angle loss 1 year after operation in the anterior group was significantly superior to that in the posterior group(P＜005). ASIA grading 1 year after operation in the two groups was significantly superior to that before operation(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The great Cobb′s angle loss is the disadvantage of pedicle screw system therapy, while the internal fixation has a long operation time and large trauma, but the postoperative spinal canal stenosis degree is small, and Cobb′s angle loss is less. Due to the advantages and disadvantages for the two surgical methods, the patients should select the appropriate surgical methods according to the specific circumstance.
    A retrospective clinical comparative analysis study on the surgical method of low rectal neuroendocrine tumors#br#
    LI Qingke1, YAO Yuan1, HAN Longcai1, LIU Yuanting1*, YE Yingjiang2
    2018, 38(6):  677-679,683.  doi:10.3969/j.issn.10073205.2018.06.014
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    ［Abstract］ Objective〖HTSS〗〓To observe and compare the efficacy and safety of the endoscopic submucosal dissection(ESD) and transanal endoscopic microsurgery(TEM) in the treatment of lower rectal neuroendocrine tumors.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Eightynine patients(grades G1 and G2) with lowgrade rectal neuroendocrine tumors(≤7 cm from the anus) were included in this study. Thirtyfive patients were treated with ESD and fiftyfour patients were treated with TEM. The operative time, intraoperative blood loss, average hospital stay were compared, And complete resection rate, perforation, and postoperative recurrence rate were followed up for 5 years after operation.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The intraoperative blood loss of the patients in the TEM group was less than that in ESD group（P＜005）. The operative time and the hospital stay of the patients in the TEM group were shorter than those in ESD group（P＜005）. There was no difference in complete resection rate, perforation, and postoperative recurrence rate between the two groups（P＞005）.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Compared with TEM has the advantages of less intraoperative blood loss, shorter operative time, and shorter hospital stay,and is worthy of clinical promotion.
    The effect of maternal low flow oxygen administration during the second stage of labor on pregnancy outcome#br#
    LI Haiying1, DUAN Lihong1*, LI Qingxue1, LiHong2, FANG Fang1
    2018, 38(6):  680-683.  doi:10.3969/j.issn.10073205.2018.06.015
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    ［Abstract］ Objective〖HTSS〗〓To assess the effect of the use of low flow  maternal oxygen during the second stage of labor on the umbilical cord artery pH and pregnancy outcome. 
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓In this randomized controlled trial(RCT), 1 100 women undergoing the second stage of labor who had no complications were randomly allocated to receive either oxygen at a flow rate of  2 L/min or sham at a flow rate of  0 L/min by the nasal cannula. Management of labor were similar in the two groups. Primary outcome was umbilical cord artery pH, and other pregnancy outcomes were recorded.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓There were no significant differences between the two groups in the fetal distress rate, neonatal asphyxia rate, instrumental vaginal delivery rate and cesarean section rate.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The use of 2 L/min maternal oxygen during the second stage of labor could not affect the umbilical cord artery pH，and could not improve the pregnancy outcome.
    Analysis of clinical features and StAR gene mutation of lipoid congenital adrenal hyperplasia#br#
    PI Yalei, ZHANG Yanan, CHONG Hemeng, CHEN Xiaoxiao, YAN Xue*
    2018, 38(6):  684-687.  doi:10.3969/j.issn.10073205.2018.06.016
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    ［Abstract］ Objective〖HTSS〗〓To analyze the clinical features and steroidogenic acute regulatory protein （StAR） gene mutation in children with lipoid congenital adrenal hyperplasia.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The clinical data of 2 children with lipoid congenital adrenal hyperplasia were collected in detail. Two milliliters venous blood of the children and their parents were collected and the exons and adjacent introns of 44 adrenal cortical dysfunction related genes of the 2 children were detected by second generation sequencing. The detected StAR gene mutation was confirmed by sanger sequencing. The StAR gene of children's parents was verified and analyzed.Literatures related to StAR gene mutation were reviewed.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓Both the 2 cases were 46XX females and neonatal onset. The main symptoms were skin pigmentation, vomiting and no weight gain; Laboratory examination showed hyponatremia and hyperkalemia, elevated adrenocorticotrophic hormone  levels, decreased serum cortisol and 17 hydroxyprogesterone and androgens levels. The growth were normal after hydrocortisone and 9αfluorocortisone replacement therapy. There were no special events in the maternal pregnancy history or the childern′s birth history as well as family history. StAR gene analysis showed that case 1 was c.229G>A(p.Q77X ) and c.772G>A(p.Q258X ) compound heterozygous mutation. Case 2 was c.707_708delAG ins CTT（p.K236Tfs*47）homozygous mutation. All are known pathogenic mutations. Both parents were mutated carriers. Together with the reported 13 cases of StAR gene mutation in China, the incidence of c.772G>A（p.Q258X）and c.707_708delAG ins CTT（p.K236Tfs*47）mutation were 53.3%(8/15) and 33.3% (5/15) respectively.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The chromosome and StAR gene should be detected in patients with primary adrenocortical dysfunction with low 17 hydroxyprogesterone and androgens, especially in female phenotypes. The mutation of c.772G>A( p.Q258X ) and c.707_708delAG ins CTT（p.K236Tfs*47） may be the hot spots of StAR gene mutation in China. Children with lipoid congenital adrenal hyperplasia  can survive for a long time and grow normally after appropriate corticosteroid replacement therapy.
    Clinical observation of humanistic nursing based on forewarning mechanism in PDR patients with vitrectomy#br#
    LIU Ying, WANG Hongxia, ZHOU Nalei, DUAN Jialiang, YANG Xin, AN Jianbin*
    2018, 38(6):  688-690,694.  doi:10.3969/j.issn.10073205.2018.06.017
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    ［Abstract］〓Objective〖HTSS〗〓To investigate the effect of humanistic nursing based on forewarming mechanism in proliferative diabetic retinopathy(PDR) patients, who need vitrectomy.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓We enrolled 112 patients with PDR, who were diagnosed with PDR and needed vitrectomy. Then the patients were divided into observation group and control group. The observation patients were given humanistic nursing based on forewarming mechanism, while patients in control group were given ordinary ophthalmic nursing. We compared the differences of mental disorders accessed by Hamilton Anxiety Scale(HAMA) and Hamilton Depression Scale(HAMD), and satisfaction of nursing between these groups.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The compliance rate of observation group was significantly higher than that of control group with(P＜005). The HAMA and HAMD scores of observation group at 7 days postoperative were significantly lower than those scores at admission, while the HAMA and HAMD scores of clinical group at 7 days postoperative were significantly higher than those scores at admission. Satisfaction rate of nursing in observation group, which was significantly higher than that of control group with(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Humanistic nursing based on forewarning mechanism takes the mental disorders of each patient into account, and demands humanistic nursing to every patient. And finally this brandnew nursing scheme yields higher compliance rate and satisfaction rate of nursing.
    Effect of ultraviolet ray and plasma irradiation on the adhesion strength of denture relining
    ZHANG Pengfei, XU Yunhai， LIANG Minying， HU Lianfang, GUO Tao， YANG Ting*
    2018, 38(6):  691-694.  doi:10.3969/j.issn.10073205.2018.06.018
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    ［Abstract］〓Objective〖HTSS〗〓To explore the effect of ultraviolet and low temperature plasma irradiation on the bond strength between denture base and hard relining material.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirtysix denture thermal coagulation samples were made and randomly divided into control group, ultraviolet group and plasma group, 12 in each group. These three groups were treated with adhesive, ultraviolet radiation + adhesive, plasma irradiation + adhesive, respectively. Each set of dental prosthesis samples and the hard lining were adhered and fixed on a fixture of an electromechanical machine. A shear rate of 0.5 mm/min was applied. The bond strength of each group was tested and compared.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The adhesion strength between ultraviolet group and plasma group was significantly higher than that of control group(P＜005). There was no significant difference in the adhesion strength between ultraviolet group and plasma group(P＞005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Surface treatment can significantly increase the bonding strength between dentures and hard linings. After ultraviolet irradiation and lowtemperature plasma irradiation, the adhesive strength between the base and the hard lining was significantly higher than that of a simple adhesive after surface treatment. Conventionally, ultraviolet or lowtemperature plasma irradiation was used to treat the surface of the material, which can improve the function of dentures, extend the service life of dentures, and reduce the economic burden on patients.
    Effect of surgical precision in 3D printing implant template for immediate implantation of anterior teeth
    ZHAO Xiaojun, WANG Huichao, XU Yunhai, HU Yongquan, LI Chuang
    2018, 38(6):  695-698.  doi:10.3969/j.issn.10073205.2018.06.019
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    ［Abstract］ Objective〖HTSS〗〓To compare the differences of surgical precision between the auxiliary method of 3d printing implant template and the conventional method in immediate implantation of anterior teeth.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Forty patients of immediate implantation in anterior teeth were selected and divided into two groups: template auxiliary and nontemplate auxiliary, with respectively 20 cases of the each group. Patients in the group of template auxiliary were taken CT scan before operation. Twenty dentistimplants of bone level with the auxiliary of 3D printing implant template are implanted and CT scan were followed once again after the operation. As for patients in the group of nontemplate auxiliary, the cone beam CT(CBCT) would be taken before operation and 20 dentist implants of bone level were planted after determining the prepared directions and angles of the cavity by doctors′ visual measurement, with CBCT following then. The implant positions of preoperative simulation and postoperative reality in both groups need to be matched. While the differences between the actual and expected positions and angles of the implants in both groups were measured respectively by the application of Mimic.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The deviation distances of neck mesialdistal, buccolingual and vertical directions in the group of template auxiliary were smaller than those in the group of nontemplate auxiliary, which had the statistical significance. The deviation angles of the mesialdistal, the deviation distances of neck buccolingual and vertical directions in the group of template auxiliary were smaller than those in the group of nontemplate auxiliary,which had the statistical significance.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓3D printing implant template could reduce the deviations from the positions and angles of implantation so as to improve its position precision.
    Oral health knowledge and related factors among the elderly in community#br#
    YU Hong1,2， ZHANG Jing3， ZANG Yu1,2， LI Yan1,2， YANG Fengjuan1,2， ZHANG Ruili1,2*
    2018, 38(6):  699-702,706.  doi:10.3969/j.issn.10073205.2018.06.020
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    ［Abstract］ Objective〖HTSS〗〓To investigate the elderly′s situation of knowledge on oral health in community, to analyze the causes and to provide a foundation for works about the elderly′s oral care.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓〖JP2〗A selfcompiled survey on the knowledge, attitude, belief, practice of the elderly′s〖JP〗 oral health were used for 1 226 old people.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The survey results show that the elderly is lack of oral health knowledge and oral health education activities. Education level, monthly income, oral health education activities are the major factors affecting the elderly′s oral health knowledge level.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Oral health education is an effective way to improve oral health knowledge of the elderly. It is recommended to carry out oral health education for the elderly, relying on the resources of the community health service center.
    Transcranial colorcoded sonography and magnetic resonance angiography in screening of diagnosing unilateral middle cerebral artery stenosis: ROC curve analysis#br#
    WANG Zheng1, WANG MingJie2*, YANG Ying1, WANG JingJing3, LIU Xin1, LI YueMing1
    2018, 38(6):  703-706.  doi:10.3969/j.issn.10073205.2018.06.021
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    ［Abstract］〓Objective〖HTSS〗〓To evaluate transcranial colorcoded sonography(TCCS) and magnetic resonance angiography(MRA) in screening of diagnosing unilateral middle cerebral artery(MCA) stenosis by using receiver operating characteristic(ROC) curve analysis. 
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 127 patients with unilateral middle cerebral artery(MCA) stenosis were enrolled in this study. TCCS, MRA and CT angiography(CTA) of head and neck were performed in all patients. Based on CTA results,137 normal MCA of root in the control group, 117 MCA with stenosis were divided into 4 categories: normal, mild stenosis, moderate stenosis and severe stenosis, then the data were evaluated using ROC curve analysis.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The two diagnostic methods of TCCS and MRA were of high value in the diagnosis of stenosis in the unilateral MCA. The area under the curve of TCCS and MRA were 0.989(95%CI 0.967-0.998) and 0.991(95%CI 0.970-0.999), and the area under the curve was not statistically significant(P＞005).The diagnostic value of MRI was higher than that of TCCS in the diagnosis of mild to moderate stenosis in the unilateral MCA. The area under the curve was 0.959(95%CI 0.796-0.941) and 0.882(95%CI 0.894-0.989) respectively, and the area under the curve was statistically different(P＜005). In the diagnosis of moderate to severe stenosis, both methods have high value, and the area under the curve is 0.939(95%CI 0.847-0.984) and 0.955(95%CI 0.868-0.991) respectively, and the area under the curve is not statistically significant(P＞005). 
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Both TCCS and MRA tests have high diagnostic value as a method for screening the arterial stenosis in the unilateral MCA, especially in the diagnosis of mild to moderate stenosis, the diagnostic value of MRA is higher than that of TCCS.
    Diagnostic efficacy of differences in corrected coronary opacification measured with computed tomography combined with biochemical index in evaluating coronary artery stenosis#br#
    YAN Liqun1, ZHANG Jingkun2*, KANG Jianli1, WANG Wenyan1, MU Xiaodan1, WANG Guoshi1
    2018, 38(6):  707-710,744.  doi:10.3969/j.issn.10073205.2018.06.022
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    ［Abstract］ Objective〖HTSS〗〓To investigate the diagnostic efficiency of differences in corrected coronary opacification(CCO) measured with computed tomography combined with biochemical indexes for coronary heart disease.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 205 patients whose left anterior descending artery stenosis rate were greater than 70%, were divided into two groups, 119 patients ≥70%, 86  patients<70%. All patients were detected with the following parameters: three glycerol(TG), total bilirubin(TBIL), gamma glutamyl transferase(GGT), total cholesterol(TC), high density lipoprotein cholesterol(HDLC), uric acid(UA), glycosylated hemoglobin(HbA1c), low density lipoprotein cholesterol(LDLC), apolipoprotein A(APOA), apolipoprotein B(APOB), Lp(a), homocysteine(Hcy). All patients were treated by CT workstation image postprocessing, the differences in CCO before and after the left anterior descending branch stenosis was measured. The Logistic regression analysis and the ROC curve were used to screen the indexes closely related to coronary heart disease, and the differences in CCO.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The difference of the biochemical indexes of the two groups was statistically significant(P＜005). Multivariate Logistic regression analysis showed that UA, GGT, Hcy, APOB, Lp (a) were independent risk factor. The stenosis rate was higher than 70%, the ROC curve is selected from the CCO, GGT, APOB. The difference of 3 indexes of AUC>0.750. The sensitivity of difference in CCO combined with GGT and APOB was 0.924, and the specificity was 0.651.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Differences in CCO combined with GGT and APOB enhanced the sensitivity to reduce the specificity, and could significantly improve the diagnostic efficiency of the coronary stenosis rate.