［Abstract］〓Objective〖HTSS〗〓To study the biochemical parameters, islet function and peripheral nerve function in type 2 diabetic patients with nonalcoholic fatty liver.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 102 patients with nonalcoholic fatty liver disease were divided into four groups: normal blood glucose group(fasting blood glucose <6.1 mmol/L and postprandial blood glucose <7.8 mmol/L), impaired glucose tolerance group(fasting blood glucose 6.1-6.9 mmol/2hour postprandial blood glucose 7.8-11.0 mmol/L), type 2 diabetic patients(fasting blood glucose ≥7.0 mmol/L, postprandial blood glucose ≥11.1 mmol/L 2 h). The biochemical indexes［homocysteine, cystatin C, thioredoxin interacting protein(TXNIP)］, islet function［insulin resistance index, islet β cell function, early phase insulin secretion index(△I30/△G30), Lee βcell function index］ were observed. The sensory nerve detection system was used to detect patients at 2, 000, 250, 5 Hz left and right median nerve, left and right sural nerve current sense threshold.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of homocysteine, cystatin C and TXNIP in patients with type 2 diabetes and impaired glucose tolerance were significantly higher than those with normal glucose levels and those with type 2 diabetes were significantly higher than those with impaired glucose tolerance(P＜005) . In type 2 diabetes mellitus group, the insulin resistance index of IGT group was higher than that of normal blood glucose group, the function of islet β cell, △I30/△G30, Lee β cell function index were lower than those of normal glucose group(P＜005). The insulin resistance index of type 2 diabetes mellitus group was higher than those of impaired glucose tolerance group, the function of islet β cell, △I30/△G30, Lee β cell function index were lower than that of glucose tolerance group, the difference was statistically significant(P＜005 ). The current sensory threshold of left and right median nerve and right and left sural nerve stimulated by different current frequency in type 2 diabetes mellitus patients were higher than those in normal glucose tolerance group and normal glucose group, and those in normal glucose tolerance group were higher than those in normal glucose group(P＜005). In patients with normal blood glucose, the sensory thresholds at 2 000 Hz were higher than 250 Hz and 5 Hz at left median nerve, right median nerve, left sural nerve and right sural nerve at 250 Hz and above 5 Hz, respectively(all P＜005). The sensory threshold of 2 000 Hz of the median nerve and left and right sural nerves in patients with impaired glucose tolerance was higher than 250 Hz and 5 Hz, and the median right and left nerves at 250 Hz and 5 Hz were significantly different(P＜005) The sensory threshold of sural nerve at 250 Hz was not significantly different from that at 5 Hz(P＜005). The sensory threshold of 2 000 Hz current in the right median nerve of type 2 diabetes mellitus was higher than 5 Hz, the current sense threshold of 2 000 Hz right sural nerve was higher than 250 Hz and 5 Hz, the difference was statistically significant(P＜005) There was no significant difference in sensory threshold of electrical stimulation at different frequencies(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Patients with alcoholic fatty liver have impaired pancreatic islet function and insulin resistance in the stage of impaired glucose tolerance, meanwhile, the sensation threshold of peripheral nerve current is also increased under the same frequency, suggesting that abnormal blood lipid and blood glucose may lead to the occurrence of peripheral neuropathy Development, homocysteine, cystatin C, TXNIP levels are also gradually increased with the progress of the disease,which may be involved in the development of the disease process.
