关键词: 心力衰竭, 胎盘生长因子, N端前脑钠肽, 预后

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the correlation of serum placental growth factor(PlGF) and Nterminal probrain natriuretic peptide type B(NTProBNP) and recent prognosis of elderly patients with chronic heart failure(CHF).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One huandred and eightyfive elderly CHF patients in our hospital were selected as CHF group and 60 patients were selected as control group during the same period. The general clinical data and serum PlGF level were collected. The main adverse cardiovascular events(MACE) were divided into MACE group and nonmace group following 6 months of followup. The relationship between PlGF and MACE was analyzed by Logistic regression equation.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Serum PlGF CHF group, NTproBNP, left ventricular enddiastolic diameter(LVEDD), left ventricular endsystolic diameter(LVESD) were higher than the control group, left ventricular ejection fraction(LVEF) and E/A were lower than the control group, comparing differences statistically significant(P＜005). The serum PlGF level was increased gradually(P＜005) with the increasing of NYHA classification. Pearson correlation analysis showed that PlGF was positively correlated with NTproBNP presentation; serum PlGF, NYHA, NTproBNP, LVEDD in MACE group were higher than nonmace group, LVEF and E/A were lower than nonmace group, and the difference was statistically significant(P＜005). Multiple Logistic regression analysis showed that PlGF level was an independent risk factor for MACE in elderly CHF patients.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Serum PlGF expression significantly higher in elderly patients with CHF, with deterioration of cardiac function level increased significantly, and positively correlated with the NTproBNP, It may be a risk factor for poor prognosis in the near future and should be paid attention to clinically.

Key words: heart failure, placental growth factor, Nterminal probrain natriuretic peptide type B, prognosis