吉西他滨灌注联合经尿道钬激光切除术对浅表性膀胱癌患者血清CXCL5及尿NMP22水平的影响

doi:10.3969/j.issn.1007-3205.2020.07.009

河北医科大学学报

吉西他滨灌注联合经尿道钬激光切除术对浅表性膀胱癌患者血清CXCL5及尿NMP22水平的影响

邢台医学高等专科学校第二附属医院泌尿外科，河北邢台 054000

出版日期:2020-07-25 发布日期:2020-07-28
作者简介:豆振京（1985-），男，河北邢台人，邢台医学高等专科学校第二附属医院主治医师，医学学士，从事泌尿外科疾病诊治研究。

Effect of holmium laser resection of bladder tumors combined with gemcitabine bladder perfusion therapy on patients with superficial bladder cancer and its affection on levels of serum CXCL5 and value of urinary NMP 22#br#

Department of Urology， the Second Affiliated Hospital of Xingtai Medical College， Hebei Province， Xingtai 054000， China

Online:2020-07-25 Published:2020-07-28

摘要/Abstract

摘要： 目的探究吉西他滨灌注联合经尿道钬激光切除术对浅表性膀胱癌患者血清趋化因子配体5（chemokine ligand-5,CXCL5）及尿核基质蛋白22（nuclear matrix protein 22,NMP 22）水平的影响。
方法选取浅表性膀胱癌患者104例，根据随机数字表法分为对照组和观察组各52例。对照组给予尿道钬激光切除术治疗，观察组在对照组的基础上联合吉西他滨灌注治疗。比较2组术后复发率、平均复发时间、平均生存时间；治疗前后比较2组血管内皮生长因子（vascular endothelial growth factor，VEGF）、成纤维细胞生长因子（fibroblast growth factor,FGF）水平、CXCL5及尿NMP22水平。
结果观察组术后1年和术后3年复发率低于对照组，平均复发时间和平均生存时间长于对照组，差异有统计学意义（P＜0.05或P＜0.01）。治疗后，2组血清VEGF、αFGF、βFGF、CXCL5和尿NMP22水平均低于治疗前，观察组血清VEGF、αFGF、βFGF、CXCL5和尿NMP22水平均低于对照组，差异有统计学意义（P＜0.01）。
结论吉西他滨灌注联合经尿道钬激光切除术治疗浅表性膀胱癌，能有效降低术后复发率，延长平均生存时间，显著降低血清CXCL5及尿NMP22水平。

关键词: 膀胱肿瘤, 吉西他滨, 经尿道钬激光切除术

Abstract: Objective〖HTSS〗To analyze the effects of holmium laser resection of bladder tumors(HOLBT) combined with gemcitabine bladder perfusion therapy on patients with superficial bladder cancer and its affection on levels of serum CXCL5 and value of urinary NMP 22.
〖WTHZ〗Methods〖HTSS〗A total of 104 patients with csuperficial bladder cancer treated were selected as research objects, and divided into control group and observation group(52 cases in each group). Control group was given HOLBT, and observation group was treated with gemcitabine bladder perfusion therapy on the basis of control group. The postoperative recurrence, average recurrence time, average survival time and serum levels of growth factor, level of CXCL5 and NMP22 were compared between two groups.
〖WTHZ〗Results〖HTSS〗The postoperative recurrence within 1 year and 3 years and the average recurrence time and average survival time in control group after treatment were significantly higher than those in observation group, the difference was statistically significant(P＜0.05 or P＜0.01). The serum VEGF, aFGF, bFGF, CXCL5 and urinary NMP22 levels in observation group were significantly lower than those in control group. After treatment, the levels of VEGF, α FGF, β FGF, CXCL5 and NMP22 in the two groups were lower than those before treatment（P＜0.01）.
〖WTHZ〗Conclusion〖HTSS〗The HOLBT combined with gemcitabine bladder perfusion therapy on patients with superficial bladder cancer, can effectively reduce postoperative recurrence, prolong the mean survival time of patients, and can significantly reduce the level of CXCL5 and NMP22.

豆振京，乔玉华*，郭荣，杨丽晖，崔剑，郝强. 吉西他滨灌注联合经尿道钬激光切除术对浅表性膀胱癌患者血清CXCL5及尿NMP22水平的影响[J]. 河北医科大学学报, doi: 10.3969/j.issn.1007-3205.2020.07.009.

DOU Zhen-jing， QIAO Yu-hua*， GUO Rong， YANG Li-hui, CUI Jian, HAO Qiang. Effect of holmium laser resection of bladder tumors combined with gemcitabine bladder perfusion therapy on patients with superficial bladder cancer and its affection on levels of serum CXCL5 and value of urinary NMP 22#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.1007-3205.2020.07.009.

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吉西他滨灌注联合经尿道钬激光切除术对浅表性膀胱癌患者血清CXCL5及尿NMP22水平的影响

Effect of holmium laser resection of bladder tumors combined with gemcitabine bladder perfusion therapy on patients with superficial bladder cancer and its affection on levels of serum CXCL5 and value of urinary NMP 22#br#

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