河北医科大学学报 ›› 2022, Vol. 43 ›› Issue (2): 160-165.doi: 10.3969/j.issn.1007-3205.2022.02.008

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乌苯美司胶囊联合放疗对宫颈癌患者的治疗效果及预后的影响

  

  1. 1.河北省邯郸市第一医院手术室,河北 邯郸 056002；2.河北省邯郸市第一医院妇产科，河北 邯郸 056002；
    3.河北省邯郸市第一医院老年病科，河北 邯郸 056002；4.河北省邯郸市第一医院心内一科，河北 邯郸 056002
  • 出版日期:2022-02-25 发布日期:2022-03-03
  • 作者简介:张利婷（1988-），女，河北曲周人，河北省邯郸市第一医院护师，医学学士，从事临床护理学研究。
  • 基金资助:
    河北省医学科学研究课题计划（20191796）

Effect of Ubenimex capsules combined with radiotherapy in the treatment of cervical cancer and its effect on prognosisof patients

  1. 1. Operating Room, the First Hospital of Handan City, Hebei Province,Handan 056002, China;
    2.Department of Gynaecology and Obstetrics, the First Hospital of Handan City, Hebei Province, 
    Handan 056002, China; 3.Department of Geriatrics, the First Hospital of Handan City, 
    Hebei Province, Handan 056002, China; 4.The First Department of Cardiology, 
    the First Hospital of Handan City, Hebei Province,Handan 056002, China
  • Online:2022-02-25 Published:2022-03-03

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摘要： 目的 探究乌苯美司胶囊联合放疗对宫颈癌患者的治疗效果及对预后的影响。
方法 选取我院收治的宫颈癌患者60例，完全随机法分为放疗治疗组、乌苯联合组各30例。放疗治疗组患者进行放疗治疗，乌苯联合组患者使用乌苯美司胶囊联合放疗治疗。黏液法检测人端粒酶逆转录酶（human telomerase reverse transcriptase，hTERT）、人乳头瘤病毒（human papilloma virus，HPV）水平；RT-PCR法检测活化的蛋白激酶C受体1（receptor for activated C kinase1,RACK1）、微小RNA-198（microrna-198，miR-198）、微小RNA-329-3p（microrna-329-3p，miR-329-3p）、Ⅱ类反式激活因子（class Ⅱ transactivators，CⅡTA）、溶酶体巯基还原酶（lysosomal thiol reductase，GILT）、天冬酰胺内肽酶（legumain，LGMN）水平；对比2组患者生活质量；酶联免疫吸附法检测血清糖链抗原724（carbohydrate antigen 724，CA724）、癌胚抗原（carcinoembryonic antigen，CEA）、鳞状细胞癌相关抗原（squamous cell carcinoma associated antigen，SCC-Ag）水平；评价临床疗效、不良反应及生存情况。
结果 与放疗治疗组相比，乌苯联合组HPV、hTERT、RACK1、miR-198、CⅡTA、GILT、FACT-G评分、FACT-Cx评分、CA724、CEA、SCC-Ag水平较低，miR-329-3p、LGMN表达水平较高（P＜0.05）。与放疗治疗组相比，乌苯联合组治疗总有效率、中位生存期、生存率均较高（P＜0.05）。
结论 乌苯美司胶囊联合放疗治疗能够改善患者RACK1、miR-198、miR-329-3p表达及肿瘤标志物水平，促进患者身体恢复，患者生存周期较长，治疗效果较为理想。


关键词: 宫颈肿瘤, 乌苯美司胶囊, 化放疗

Abstract: Objective To explore the therapeutic effect and prognostic effect of Ubenimex capsule combined with radiotherapy in patients with cervical cancer. 
Methods A total of 60 patients with cervical cancer admitted to our hospital were randomly divided into radiotherapy group and combination group, with 30 cases in each group. Patients in the radiotherapy group received radiotherapy, and patients in the combination group received Ubenimex capsule combined with radiotherapy. Human telomerase reverse transcriptase(hTERT) and human papillomavirus(HPV) were detected by mucus assay. Receptor for activated C kinase 1(RACK1), microRNA-198(miR-198), microRNA-329-3p(miR-329-3p), classⅡ transactivators(CIITA), gamma-interferon-inducible lysosomal thiol reductase(GILT), and asparagine endopeptidase(LGN) were detected by RT-PCR. The quality of life between two groups was compared. Serum carbohydrate antigen 724(CA724), carcinoembryonic antigen(CEA) and squamous cell carcinoma associated antigen(SCC-Ag) were detected by enzyme-linked immunosorbent assay(ELISA). Clinical efficacy, adverse reactions and survival were evaluated. 
Results Compared with the radiotherapy group, the levels of HPV, hTERT, RACK1, miR-198, CIITA, GILT, FACT-G score, FACT-CX score, CA724, CEA and SCC-Ag in the combination group were lower, while the expression levels of miR-329-3p and LGMN were higher(P＜0.05). Compared with the radiotherapy group, the total response rate, median survival time and survival rate were higher in the combination group(P＜0.05). 
Conclusion Ubenimex capsule combined with radiotherapy can improve the expression of RACK1, miR-198, miR-329-3p and the level of tumor markers in patients, and promote the recovery of patients, ensuring long survival of patients and good therapeutic effect.


Key words: uterine cervical neoplasms, ubenimex capsule, chemoradiotherapy 

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