关键词: 缺血性卒中, 尿酸, 再发脑卒中

Abstract: Objective To analyze the correlation between serum uric acid (SUA) level and acute ischemic stroke (AIS) patients with recurrent stroke within one year. 
Methods A total of 98 patients with AIS treated in the Department of Neurology were enrolled, and the patients were regularly followed up to record the recurrence of stroke within one year after discharge and the time of no recurrence of stroke. According to the median SUA of the subjects, the patients were divided into high SUA group (n=49) and low SUA group (n=49), and the basic clinical data of patients, laboratory tests and National Institute of Health Stroke Scale(NIHSS) scores on the day of admission were collected. The recurrent stroke of the two groups was compared, the clinical value of SUA in predicting recurrent stroke was evaluated by ROC curve, and the factors affecting recurrent stroke were explored by binary logistic regression analysis. 
Results The incidence of recurrent stroke in the low SUA group was significantly lower than that in the high SUA group, and the survival time of patients without recurrent stroke in the low SUA group was longer than that in the high SUA group (P＜0.05). According to the ROC curve, SUA had a higher value in predicting recurrent stroke in AIS patients within one year. In terms of the area under ROC curve (AUC), 95% confidence interval (CI) was 0.85 (0.75-0.94), and the optimal diagnostic threshold was 417.89 μmol/L. The sensitivity under this diagnostic threshold was 0.87, and the specificity was 0.92. Age ＞53.06 years old, LDL-C ＞3.17 mmol/L, SUA ＞349.25 μmol/L, and NIHSS score ＞12.43 were independent risk factors for recurrent stroke within one year in AIS patients (P＜0.05). 
Conclusion SUA may be an independent risk factor for recurrent stroke within one year in patients with AIS, and is a potential laboratory indicator to help clinicians identify poor prognosis in patients with AIS. 

Key words: ischemic stroke, uric acid, recurrent stroke