关键词: 糖尿病, 2型, 高尿酸血症, 尿酸

Abstract: Objective To explore the correlation between serum uric acid(UA), neutrophil-to-lymphocyte ratio(NLR), and γ-glutamyl transpeptidase(γ-GT) in patients with type 2 diabetes mellitus(T2DM) complicated with hyperuricemia and the influencing factors of hyperuricemia. 
Methods A total of 270 outpatients and inpatients with T2DM treated in the Second People′s Hospital of Changshu City, Jiangsu Province were selected. According to presence or absence of hyperuricemia, the patients were divided into diabetic group and combination group. Another 60 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. The expression of serum UA, NLR and γ-GT in the three groups was compared, and the correlation between serum UA, NLR and γ-GT was analyzed by Pearman method. Univariate and unconditional Logistic regression analyses were used to determine the independent influencing factors of hyperuricemia. 
Results The differences in serumUA, NLR and γ-GT were statistically significant in three groups(F=451.351, 78.706, 314.433, P＜0.001). SerumUA, NLR and γ-GT were significantly higher in the combination group than in the diabetic group and the control group, and serum UA, NLR and γ-GT in the diabetic group were significantly higher than those in the control group. Blood UA was positively correlated with NLR and γ-GT(r=0.423, 0.730, P＜0.001). There were significant differences in the two groups with respect to hypertension(χ2=89.708, P＜0.001), hyperlipidemia(χ2=5.575, P=0.018), fatty liver(χ2=7.614, P=0.006), retinopathy(χ2=110.174, P＜0.001), lower limb vascular disease(χ2=14.110, P＜0.001), coronary atherosclerotic heart disease(χ2=35.042, P＜0.001), course of disease(t=8.242, P＜0.001), glycated hemoglobin(t=10.697, P＜0.001), fasting glucose(t=11.510, P＜0.001), triacylglycerol(t=22.108, P＜0.001), high-density lipoprotein(t=4.488, P＜0.001 ), low-density lipoprotein(t=2.006, P=0.048), blood creatinine(t=5.691, P＜0.001) and diastolic blood pressure(t=7.835, P＜0.001). Logistic regression showed that the differences in age(OR=1.208, 95%CI:1.013-1.441), course of disease(OR=1.536, 95%CI:1.188-1.985), glycosylated hemoglobin(OR=2.184, 95%CI:1.473-3.238), NLR(OR=2.977, 95%CI:1.889-4.691) and γ-GT(OR=1.655, 95%CI:1.363-2.010) were independent influencing factors of hyperuricemia(P＜0.05). 
Conclusion Serum UAis positively correlated with NLR and γ-GT in patients with T2DM complicated with hyperuricemia. Age, course of disease, glycosylated hemoglobin, NLR and γ-GT are independent risk factors for hyperuricemia, which is worthy of further clinical study and promotion.

Key words: diabetes mellitus, type 2, hyperuricemia, uric acid