不同剂量丹参注射液联合匹多莫德治疗儿童过敏性紫癜的效果分析

doi:10.3969/j.issn.10073205.2018.01.016

河北医科大学学报

不同剂量丹参注射液联合匹多莫德治疗儿童过敏性紫癜的效果分析

1.鄂东医疗集团黄石市中心医院儿科，湖北黄石 435000；2.鄂东医疗集团黄石市中心医院普爱院区儿科，湖北黄石 435000

出版日期:2018-01-25 发布日期:2018-01-05
作者简介:刘杰（1982-），男，湖北黄石人，鄂东医疗集团黄石市中心医院主治医师，医学硕士，从事小儿内科疾病诊治研究。

Efficacy analysis of different doses danshen injection combined with pidotimod in the treatment of child's henoch schonlein purpura#br#

1.Department of Pediatrics, EDong Helathcare Group Huangshi Central Hospital, Hubei Province，
Huangshi 435000， China；2.Department of Pediatrics, EDong Healthcare Group Huangshi
Central Hospital Puai Hospital， Hubei Province， Huangshi 435000， China

Online:2018-01-25 Published:2018-01-05

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗比较不同剂量丹参注射液联合匹多莫得对儿童过敏性紫癜的临床效果。
〖HTH〗方法〖HTSS〗〖KG*2〗将黄石市中心医院儿科收治的152例过敏性紫癜患儿随机分为3组，分别为匹多莫德组（49例）、常规剂量联合组（51例）和大剂量联合组（52例）。所有患儿均给予常规治疗，匹多莫德组加用匹多莫德400 mg/d，常规剂量联合组给予丹参注射液10 mL/d+匹多莫德400 mg/d，大剂量联合组给予丹参注射液20 mL/d+匹多莫德400 mg/d，疗程持续14 d，观察记录3组临床症状消失时间、6个月后复发率、治疗前后外周血中免疫功能和氧化应激指标变化，并比较临床疗效。
〖HTH〗结果〖HTSS〗〖KG*2〗治疗14 d后，常规剂量联合组和大剂量联合组临床症状（紫癜、腹痛、关节痛、皮疹及肾脏损害）消失时间均短于匹多莫德组，大剂量联合组临床症状消失时间短于常规剂量组（P＜0.05）。随访6个月后，大剂量联合组复发率低于匹多莫德组和常规剂量联合组（P＜0.05）。与治疗前相比，3组血浆谷胱甘肽过氧化物酶、超氧化物歧化酶、CD3+、CD4+、CD8+及CD4+/CD8+含量均得到改善，但大剂量联合组较另外2组改善更为明显，常规剂量联合组较匹多莫德组改善明显（P＜0.05）。匹多莫德组治愈率和总有效率均低于常规剂量联合组和大剂量联合组，且常规剂量联合组治愈率和总有效率均低于大剂量联合组（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗应用大剂量丹参注射液联合匹多莫德治疗儿童过敏性紫癜能取得较好的临床疗效，有效降低复发率，安全可靠，值得在临床上应用。

关键词: 紫癜, 过敏性, 丹参注射液, 匹多莫德, 儿童

Abstract: ［Abstract］ Objective〖HTSS〗〓To compare the clinical efficacy of different doses danshen injection combined with pidotimod in the treatment of henoch schonlein purpura(HSP) .
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 152 cases of children with HSP admitted into pediatric department of Huangshi central hospital were randomly divided into three groups: pidotimod group(n=49), conventionaldose combination group(n=51) and large dose combination group(n=52). Three groups all were received conventional medical treatment, Pidotimod group accepted pidotimod 400 mg/d, conventionaldose combination group accepted Danshen injection 10 mL/d combined with pidotimod 400 mg/d, while the large dose group accepted Danshen injection 20 mL/d combined with pidotimod 400 mg/d. The treatment course lasted for 2 weeks. The clinical symptoms disappeared time, the recurrence rate after 6 months, peripheral blood immune function, oxidative stress parameters contents before and after the treatment and the clinical efficacy of 3 groups were recorded.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The clinical symptoms including purpura, abdominal pain, joint pain, skin rashes and kidney damage disappeared time of conventionaldose combination group and large dose combination group were lower than that of pidotimod group, that of large dose combination group was lower than that of conventionaldose combination group(P＜0.05). The recurrence rate of large dose combination group was significantly lower than that of other group by six months followup time(P＜005）. After treatment, the glutathione peroxidase, superoxide dismutase, CD3+, CD4+, CD8+ and CD4+/CD8+ of three groups were all improved, but large combination dose group was better than the other two groups, conventionaldose combination was better than the pidotimod groups(P＜0.05). The cure rate and total effective rate of pidotimod group was lower than that in conventionaldose combination group and large combination dose group, the conventionaldose combination group was lower than large combination dose group ,all the differences were statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Large dose danshen injection combined with pidotimod in the treatment of children with HSP can achieve a higher clinical efficacy, reduce the recurrence rate, and is safe and reliable, which is worthy of clinical application.

Key words: purpura, henochschonlein, Danshen injection, pidotimod, child

刘〓杰1，岑〓敏2*，王〓冠1. 不同剂量丹参注射液联合匹多莫德治疗儿童过敏性紫癜的效果分析[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.01.016.

LIU Jie1, CEN Min2*, WANG Guan1. Efficacy analysis of different doses danshen injection combined with pidotimod in the treatment of child's henoch schonlein purpura#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.01.016.

[1]	磨焕鹏, 胡东辉, 邓妙芳, 张亚忠, 何晖. 经皮交叉克氏针内固定治疗儿童Gartland Ⅲ型肱骨髁上骨折的疗效 [J]. 河北医科大学学报, 2023, 44(2): 184-188,235.
[2]	张文超, 赵梦川, 何宝花, 贾肇一, 李梅, 郭映辉. 血流感染患儿流感嗜血杆菌流行特征及耐药性 [J]. 河北医科大学学报, 2023, 44(12): 1467-1471.
[3]	马志华, 布力布丽·巴哈提, 阿布来提·阿不都哈尔. 小儿过敏性紫癜性肾炎SOCS-3及HMGB1与Th17/Treg细胞失衡的关系 [J]. 河北医科大学学报, 2023, 44(1): 91-94,99.
[4]	田苡任, 任强, 周湘, 甄磊, 郑美娜, 张放. 3~6岁儿童寰枢椎椎弓根在3D打印技术下的测量研究[J]. 河北医科大学学报, 2022, 43(3): 311-315，325.
[5]	张晓双, 黄珊珊, 闫红, 徐茜茹, 杜鸿飞, 张佳佳. 石家庄地区16 490例过敏患儿过敏原分布特征分析[J]. 河北医科大学学报, 2022, 43(3): 345-349.
[6]	徐锋. 探讨β2M、CD62P、CD63表达水平对ITP临床诊断价值的研究 [J]. 河北医科大学学报, 2022, 43(11): 1323-1327.
[7]	吴会芳, 张景丽, 刘晓娟, 吴晓杰, 段晨初, 张中平. HMGB1、GM-CSF、LDH在慢性肺炎患儿中的表达及相关性研究 [J]. 河北医科大学学报, 2022, 43(10): 1158-1162.
[8]	温婵, 张丽霞, 孙玲. 2011-2019年河北某儿童医院耐甲氧西林金黄色葡萄球菌分布特点及耐药性变迁[J]. 河北医科大学学报, 2022, 43(1): 84-87.
[9]	赵宁, 贺新建, 李易明. 超声心动图改善儿童PICC尖端右心异位的评估研究[J]. 河北医科大学学报, 2021, 42(5): 592-596.
[10]	周辉, 仲智勇. 一种儿童完全植入式静脉输液港尖端定位中的新型方法及应用[J]. 河北医科大学学报, 2021, 42(5): 603-606.
[11]	白磊鹏, 吕家兴, 王瑜, 孔庆柱, 金宇, 赵景新. 经皮穿针联合外固定架微创治疗大龄儿童肱骨近端骨折的效果分析[J]. 河北医科大学学报, 2021, 42(4): 420-424.
[12]	谷海飞, 李超, 张明, 杜文康. 肺保护性通气策略联合不同剂量顺式阿曲库铵对小儿日间腹腔镜手术的影响[J]. 河北医科大学学报, 2021, 42(2): 231-234.
[13]	郑芳, 卞相丽, 李妙晨, 吴志敏. 沙美特罗替卡松气雾剂联合粉尘螨滴剂舌下免疫治疗尘螨过敏性哮喘的临床效果[J]. 河北医科大学学报, 2021, 42(10): 1180-1184.
[14]	赵汝莲，王阳，皮练鸿*. 儿童轻度过敏性结膜炎中干眼的研究及治疗[J]. 河北医科大学学报, 2020, 41(9): 1065-1069.
[15]	弭莉1，杜潘艳2. 儿童支原体肺炎急性期2种检测方法的比较及意义#br#[J]. 河北医科大学学报, 2020, 41(7): 834-837.

不同剂量丹参注射液联合匹多莫德治疗儿童过敏性紫癜的效果分析

Efficacy analysis of different doses danshen injection combined with pidotimod in the treatment of child's henoch schonlein purpura#br#

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价