河北医科大学学报

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缺血性脑卒中颈动脉狭窄与脑微出血关系的研究#br#

  

  1. 1.河北省石家庄市第一医院神经内科,河北 石家庄 050011;2.河北省石家庄市第一医院眼科,河北 石家庄 050011
  • 出版日期:2018-10-25 发布日期:2018-09-27
  • 作者简介:张军(1977-),男,河北衡水人,河北省石家庄市第一医院主治医师,医学硕士,从事神经内科疾病诊治研究。
  • 基金资助:
    石家庄市科学技术研究与发展指导计划(141462463)

Study on the correlation between carotid artery stenosis and cerebral microbleeds in ischemic stroke

  1. .Department of Neurology, the First Hospital of Shijiazhuang, Hebei Province, Shijiazhuang
    050011, China; 2.Department of Ophtholmology, the First Hospital of Shijiazhuang,
    Hebei Province, Shijiazhuang 050011, China
  • Online:2018-10-25 Published:2018-09-27

摘要: [摘要]〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨缺血性脑卒中患者颈动脉狭窄与脑微出血(cerebral microbleeds,CMBs)的关系。
〖HTH〗方法〖HTSS〗〖KG*2〗缺血性脑卒中患者268例根据血管狭窄程度分为4组:轻度组(血管狭窄程度0%~49%)96例,中度组(血管狭窄程度50%~69%)87例,重度组(血管狭窄程度70%~99%)53例,闭塞组(血管完全闭塞)32例。应用3.0 T Philips磁共振成像行磁敏感加权成像扫描的方法,检查6个月和12个月后各组新增CMBs。
〖HTH〗结果〖HTSS〗〖KG*2〗在皮层及皮层下区、基底节区,6个月和12个月时,均有随着颈动脉狭窄程度增加CMBs也逐渐增加的趋势,尤其是在12个月时皮层及皮层下区,组间总的差异有统计学意义(P<005),但各组两两之间比较差异无统计学意义(P>005)。在6个月和12个月,各组所有部位新增加的CMBs有随着颈动脉狭窄程度增加而逐渐增加的趋势,但6个月时组间比较差异无统计学意义(P>005),12个月时组间总的差异有统计学意义(P<005),但各组两两之间比较差异无统计学意义(P>005)。
〖HTH〗结论〖HTSS〗〖KG*2〗缺血性脑卒中患者,有随着颈动脉狭窄程度增加CMBs逐渐增加的趋势,且随着时间延长,CMBs的发生概率增大。

关键词: 卒中, 脑微出血, 颈动脉狭窄, 磁共振成像

Abstract: [Abstract] Objective〖HTSS〗〓To discuss the correlation between carotid artery stenosis(CAS)and cerebral microbleeds(CMBs) in patients with ischemic stroke.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Two hundred and sixtyeight patients with ischemic stroke were divided into four groups according to the degree of CAS: the slight stenosis group(ninetysix cases, the degree of CAS was zero to fourtynine percent), moderate stenosis group(eightyseven cases, the degree of CAS was fifth to sixtynine percent), severe stenosis group (fiftythree cases,the degree of CAS was seventy to ninetynine percent) and total occlusion group (thirtytwo cases, carotid artery was completely blocked). All patients were examined with susceptibility weighted imaging by 3.0T magnetic resonance imaging. New CMBs were counted after six months and twelve months.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓 In the cortex, subcortical area and basal ganglia, new CMBs were increased gradually with the increasing degree of CAS at the sixth month and the twelfth month. Especially in the cortex and the subcortical area at the twelfth month, the difference of total comparison was significantly statistical between the groups(P<005), but there were no statistical differences between every two groups(P>005). At the sixth month and the twelfth month,the new CMBs in all parts of each group showed a trend of gradual increasewith the increasing degree of CAS. At the sixth month, there were no significantdifferences between the groups(P>005). At the twelfth month, there was statistical difference of total comparison between the groups(P<005), but the differences were no statistical between every two groups(P>005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The CMBs tends to increase gradually with the increasing degree of CAS in ischemic stroke and the probability of occurrence of CMBs is increased with the extension of time.

Key words: stroke; cerebral microbleeds, carotid artery stenosis, magnetic resonance imaging