河北医科大学学报

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CT测量腹部脂肪面积与简易体脂参数对胰岛素抵抗评价作用的对比

  

  1. 1.山东省潍坊妇幼保健院儿科，山东 潍坊 261011；2.河北医科大学第三医院内分泌一科，河北 石家庄 050051
  • 出版日期:2019-12-25 发布日期:2018-12-29
  • 作者简介:王媛媛（1984-），女，山东潍坊人，山东省潍坊妇幼保健院主治医师，医学硕士，从事儿科疾病诊治研究。

The comparison between abdominal obesity measured by CT and simple body fat parameters for the evaluation of insulin resistance#br#

  1. 1.Department of Pediatrics， the Maternity and Child Care Center of Weifang, Shandong Province,
    Weifang 261011，China； 2.The First Department of Endocrinology，the Third Hospital of
    Hebei Medical University，Shijiazhuang 050051， China
  • Online:2019-12-25 Published:2018-12-29

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨CT测量腹部脂肪面积与简易体脂参数对胰岛素抵抗（insulin resistance,IR）的评价作用。
〖HTH〗方法〖HTSS〗〖KG*2〗选择腹型肥胖且糖耐量正常的患者50例和伴腹型肥胖的2型糖尿病（type 2 diabetes mellitus,T2DM）患者50例，检测2组腰围、臀围、体重指数(body mass index,BMI)、空腹血糖值(fasting blood glucose,FBG)、空腹胰岛素(fasting insulin,FINS)、空腹C肽、三酰甘油(triglycerides,TG)、高密度脂蛋白胆固醇(highdensity lipoprotein cholesterol，HDLC)、低密度脂蛋白胆固醇(lowdensity lipoprotein cholesterol,LDLC)、IR指数(HOMA1insulin resistance index,HOMA1IRI)、腹部内脏脂肪面积（the area of intraabdominal adipose，I）、皮下脂肪面积（the area of subcutaneous adipose，S）及I/S比值。分析lnHOMA1IRI与各指标的相关性。
〖HTH〗结果〖HTSS〗〖KG*2〗T2DM组FBG、FINS、空腹C肽、HOMA1IRI、lnHOMA1IRI、腹部内脏脂肪面积、I/S比值高于对照组，HDLC低于对照组，差异有统计学意义（P＜005）。lnHOMA1IRI与FBG、FINS、空腹C肽、LDLC、TG、腹部内脏脂肪面积、I/S比值、HOMA1IRI呈正相关（P＜005），与HDLC呈负相关（P＜005），与腰围、腰臀比、BMI、皮下脂肪面积无相关性（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗CT测量腹部脂肪面积评价IR较简易体脂参数更敏感。

关键词: 糖尿病, 2型, 肥胖, 腹部, 胰岛素抵抗

Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the effects for evaluating insulin resistance (IR) by abdominal obesity measured by CT or through simple body fat parameters.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Fifty patients with abdominal obesity and with normal glucose tolerance(Control group) and fifty patients with type 2 diabetes mellitus and abdominal obesity(T2DM group) were recruited. Waistline, hipline, body mass index(BMI), fasting blood glucose(FBG), fasting insulin(FINS), fasting Cpeptide, triglycerides(TG), highdensity lipoprotein cholesterol(HDLC), lowdensity lipoprotein cholesterol(LDLC), HOMA1insulin resistance index(HOMA1IRI), the area of intraabdominal adipose(I), the area of subcutaneous adipose(S), I/S ratio were detected. The correlation between HOMA1IRI and the other indexes above were analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓FBG, FINS, fasting Cpeptide, HOMA1IRI, lnHOMA1IRI, the area of intraabdominal adipose, I/S ratio were higher in T2DM group than that in the control group,  HDLC was much lower in T2DM group than that in the control group(P＜005). There was no significant difference in LDLC and the ratio of waistline and hipline between the two groups. There was a significantly positive correlation between lnHOMA1IRI and FBG, FINS, fasting Cpeptide, LDLC, TG, the area of intraabdominal adipose, I/S ratio, and HOMA1IRI. And there was a significantly negative correlation between lnHOMA1IRI and HDLC.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Abdominal obesity measured by CT was more sensitive than simple body fat parameters to evaluate IR.

Key words: diabetes mellitus, type 2, obesity, abdomen, insulin resistance

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