河北医科大学学报

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老年维持性血液透析患者穿透素3与超敏C反应蛋白和营养不良的关系

  

  1. 承德医学院附属医院肾脏内科,河北 承德  067000
  • 出版日期:2019-06-25 发布日期:2019-06-19
  • 作者简介:刘洁琼(1990-),女,河北沧州人,承德医学院附属医院医学硕士研究生,从事肾内科疾病诊治研究。

Relationship among pentraxin3, hypersensitive Creactive protein and malnutrition in hemodialysis patients of old age#br#

  1. Department of Nephrology, Affiliated Hospital of Chengde Medical College, Hebei Province, Chengde 067000, China
  • Online:2019-06-25 Published:2019-06-19

摘要: [摘要]〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨老年维持性血液透析(maintenance hemodialysis,MHD)患者穿透素3(pentraxin3,PTX3)与超敏C反应蛋白(hypersensitive Creactive protein,hsCRP)和营养不良的相关性。
〖HTH〗方法〖HTSS〗〖KG*2〗选择MHD治疗3个月以上,尿素清除指数(urea clearance index,Kt/V)>1.2的患者77例,按年龄分为老年组组51例和非老年组26例。比较2组主观综合营养评估(Subjective Global Assessement,SGA)、Kt/V、尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,SCr)、血清白蛋白(serum albumin,ALB)、血红蛋白(hemoglobin,Hb)、PTX3、hsCRP。分析老年MHD患者PTX3与SGA 、hsCRP、ALB的相关性。
〖HTH〗结果〖HTSS〗〖KG*2〗老年组营养不良发生率和hsCRP、PTX3水平显著高于非老年组,ALB、SCr、BUN水平显著低于非老年组,差异均有统计学意义(P<005)。相关性分析结果显示,老年MHD患者PTX3与hsCRP、SGA呈正相关,与ALB呈负相关(P<005)。
〖HTH〗结论〖HTSS〗〖KG*2〗老年MHD患者营养不良发生率较高,PTX3可作为提示老年MHD患者营养不良的指标。

关键词: 肾透析, 穿透素3, C反应蛋白质, 营养不良

Abstract: [Abstract]〓Objective〖HTSS〗〓To investigate the relationship among pentraxin3(PTX3), hypersensitive Creactive protein(hsCRP) and malnutrition in patients of old age with maintenance hemodialysis(MHD).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Seventyseven MHD patients treated more than three months,with urea clearance index(Kt/V)>1.2, were included in this study. Fiftyone old MHD patients who were sixtyfive and above were in one group, while twentysix MHD patients who were less than sixtyfive years old were in the other group. Subjective Global Assessment(SGA), Kt/V, blood urea nitrogen(BUN), serum creatinine(SCr), serum albumin(ALB), hemoglobin(Hb), PTX3 and hsCRP were compared in two groups. The bivariate correction analysis of PTX3, SGA, hsCRP and ALB was measured in the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There were higher levels of PTX3 and hsCRP,SGA, while lower levels of SCr, BUN and ALB (P<005) in old MHD patients. The value of PTX3 was positively relative with hsCRP and SGA, while negatively with ALB(P<005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The incidence rate of malnutrition was higher in old MHD patients. PTX3 could detect the malnutrition.

Key words: renal dialysis, pentraxin3, Creactive protein, malnutrition