河北医科大学学报 ›› 2022, Vol. 43 ›› Issue (4): 433-438.doi: 10.3969/j.issn.1007-3205.2022.04.013

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精神分裂症患者一级亲属血清C反应蛋白水平及其相关因素研究

  

  1. 1.河北省唐山市开滦精神卫生中心心身研究室，河北 唐山 063000；2.河北省唐山市开滦精神卫生中心四病区，

    河北 唐山 063000；3.河北省唐山市开滦总医院神经外科,河北 唐山 063000； 4.河北省唐山市开滦精神卫生中心机关,河北 唐山 063000

  • 出版日期:2022-04-25 发布日期:2022-04-30
  • 作者简介:张顺（1978-），男，天津人，河北省唐山市开滦精神卫生中心副主任医师，医学学士，从事睡眠医学、精神分裂症认知功能方向研究。
  • 基金资助:
    河北省医学科学科技成果推广课题（20181460）

Study on the levels of C-reactive protein of first-degree relatives of schizophrenia patients and its related factors

  1. 1.Department of Psychosomatic Laboratory, Kailuan Mental Health Centre of Tangshan City, Hebei

    Province, Tangshan 063000, China; 2.The Fourth Inpatient Ward, Kailuan Mental Health Centre of

    Tangshan City, Hebei Province, Tangshan 063000, China; 3.Department of Neurosurgery,

    Kailuan Mental Health Centre of Tangshan City, Hebei Province, Tangshan 063000,

    China; 4.Department of Office, Kailuan Mental Health Centre of Tangshan City, Hebei Province, Tangshan 063000,  China

  • Online:2022-04-25 Published:2022-04-30

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摘要：

目的  观察精神分裂症患者一级亲属血清C反应蛋白（C-reactive protein，CRP）水平表达，分析其血清CRP水平变化可能的相关因素。

方法  选择医院住院治疗的精神分裂症患者100例及其一级亲属175例作为研究对象，将精神分裂症者作为精神分裂症组，将一级亲属作为一级亲属组，并选择同期医院接受全身体检证实为身体健康的200名人群作为健康对照组。对全部调查人员均测定血清CRP水平，一级亲属接受症状自评量表（symptom checklist，SCL-90）、精神分裂症认知功能成套测验（MATRICS consensus cognitive battery,MCCB）、阳性和阴性症状量表（positive and negative symptom scale ,PANSS）等评分测试评定。比较3组血清CRP水平表达，比较一级亲属与健康对照组SCL-90评分；对比一级亲属不同性别、年龄、心理健康状况、认知功能、症状严重程度等情况下的CRP水平表达，经线性回归分析一级亲属血清CRP水平异常可能的相关因素。

结果  3组受检者中，精神分裂症组患者血清CRP水平最高，后由高至低依次为一级家属组、健康对照组，组间比较，差异有统计学意义（P＜0.05）；较健康对照组，一级亲属组强迫症状、躯体化、人际关系敏感、焦虑、抑郁、敌对、恐惧、偏执、精神病性得分及总得分均高于健康对照组，差异有统计学意义（P＜0.05）。经线性回归分析检验结果显示，心理健康状态不佳、认知功能低下及中重度症状均可能是影响精神分裂症一级亲属血清CRP水平的相关因素（P＜0.05）。

结论  精神分裂症患者一级亲属血清CRP水平呈高表达，可能与一级亲属不良心理健康状况、认知功能低下、合并一定程度的精神分裂症症状等因素有关，对于家族有精神分裂症治疗史的人群，若精神分裂症患者是其一级亲属，应注意血清CRP水平表达的变化，若发现血清CRP呈异常高表达，应及时干预，以减少精神分裂症的发生。

关键词: 精神分裂症, 家庭, C反应蛋白质

Abstract:

Objective  To observe the expression of C-reactive protein(CRP) of first-degree relatives(FDR) of schizophrenia patients, and to analyze the related factors of changes of serum CRP.

Methods  In total, 100 schizophrenia patients who were hospitalized and 175 FDR were selected as research subjects. Patients with schizophrenia were taken as schizophrenia group, and the FDR served as FDR group. Another 200 healthy people who underwent physical examination in the hospital were selected as healthy control group. The serum CRP levels of all subjects were detected, and FDR was assessed by the symptom checklist(SCL-90), MATRICS consensus cognitive battery(MCCB) and positive and negative symptom scale(PANSS). The expressions of serum CRP levels were compared among the three groups, and the SCL-90 scores of FDR group and healthy control group were compared. The expression of CRP levels of FDR with different gender, age, mental health status, cognitive function, severity of symptoms were compared, and linear regression analysis was used to analyze the potential factors related to abnormal CRP levels in FDR.

Results  Among three groups, the serum CRP level of schizophrenia group was the highest, followed by FDR group and healthy control group, and the difference was statistically significant between groups(P＜0.05). The compulsive symptoms, somatization, interpersonal sensitivity, anxiety, depression, hostility, fear, paranoia, psychotic scores and total score in FDR group were higher than those in healthy control group, suggesting significant differences(P＜0.05). The results of linear regression analysis showed that poor mental health, poor cognitive impairment and moderate to severe symptoms might be related factors affecting serum CRP levels in FDR of patients with schizophrenia(P＜0.05).

Conclusion  The serum CRP level of FDR of patients with schizophrenia is highly expressed, which may be related to the poor mental health status, poor cognitive impairment, and combined symptoms of FDR with certain degree of schizophrenia. For people with a family history of schizophrenia treatment, if the schizophrenia patient is FDR, attention should be paid to the changes of expression of serum CRP levels. Serum CRP that is found to be abnormally high should be promptly intervened to reduce the incidence of schizophrenia.

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