河北医科大学学报

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TGFβ1、Slug及Ecadherin 在胆管癌组织中的表达及意义

  

  1. 1.河北医科大学第二医院肝胆外科，河北 石家庄 050000；2.河北医科大学第三医院肿瘤科，河北 石家庄 050051
  • 出版日期:2017-11-25 发布日期:2017-11-16
  • 作者简介:王文斌（1973-），男，河北保定人，河北医科大学第二医院副主任医师，医学博士，从事肝胆胰脾疾病诊治研究。

The expression and clinical significance of TGFβ1、Slug and Ecadherin in cholangiocarcinoma

  1. 1.Department of Hepatobiliary Surgery, the Second  Hospital of Hebei Medical University, Shijiazhuang
    050000, China; 2.Department of Oncology, the Third Hospital of Hebei
    Medical University, Shijiazhuang 050051, China
  • Online:2017-11-25 Published:2017-11-16

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨TGFβ1、Slug和Ecadherin在胆管癌组织中的表达并分析其临床意义。
〖HTH〗方法〖HTSS〗〖KG*2〗采用免疫组织化学SP法检测TGFβ1、slug和Ecadherin在70例胆管癌组织和20例癌旁组织中的表达情况，分析其临床意义。
〖HTH〗结果〖HTSS〗〖KG*2〗70例胆管癌、20例胆管癌癌旁组织中TGFβ1、Slug和Ecadherin阳性表达率差异均有统计学意义（P＜005）。TGFβ1和Slug阳性表达率在淋巴结转移者高于无淋巴结转移者（P＜005），在肝动脉或门静脉受侵者高于无受侵者（P＜005）。Ecadherin阳性表达率在淋巴结转移者低于无淋巴结转移者（P＜005），在肝动脉或门静脉受侵者低于无受侵者（P＜005）。胆管癌组织中，TGFβ1与Slug表达呈正相关（rs=0.658, P=0000）；TGFβ1与Ecadherin表达呈负相关（rs=-0.527, P=0000）；Slug与Ecadherin表达呈负相关（rs=-0.526,P=0000）。
〖HTH〗结论〖HTSS〗〖KG*2〗TGFβ1、Slug及Ecadherin表达对胆管癌的发生发展可能发挥重要的作用。

关键词: 胆管肿瘤, 转化生长因子&beta, 1, 桥粒钙黏蛋白质类

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the expression of TGFβ1, Slug and Ecadherin in  cholangiocarcinoma tissues and their clinical significance.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Immunohistochemical SP method was used to detect the expression of TGFβ1, Slug and Ecadherin in 70 cases of cholangiocarcinoma and 20 cases of paratumor tissue. The clinical significance were analyzed. The correlation between expression of TGFβ1, Slug and Ecadherin was analyzed by Spearman analysis method.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive expression rates of TGFβ1, Slug and Ecadherin in cholangiocarcinoma tissue were significantly different from those in paratumor tissue（P＜005）. The positive expression rates of TGFβ1 and Slug were significantly higher in lymph node metastasis and hepatic artery or portal vein invasion patients than those in no lymph node metastasis（P<0.05）and hepatic artery or portal vein invasion patients(P＜005）. The positive expression rates of Ecadherin were significantly lower in lymph node metastasis and hepatic artery or portal vein invasion patients than those in no lymph node metastasis（P＜005）and hepatic artery or portal vein invasion patients(P＜005）. There was a positive correlation  between TGFβ1 and Slug expression in cholangiocarcinoma（rs=0.658, P=0000）. There were  negative correlations between TGFβ1 and Ecadherin（rs=-0.527, P=0000）. The expression of Slug was negatively correlated with the expression of Ecadherin（rs=-0.526, P=0000）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The abnormal expressions of TGFβ1, Slug and Ecadherin may play an important role in carcinogenesis and progression of cholangiocarcinoma.

Key words: bile duct neoplasms； , transforming growth factor beta 1, desmosomal cadherins

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