河北医科大学学报

• 论著 • 上一篇    下一篇

HIF1α及其靶基因在宫颈癌中的表达#br#

  

  1. 1.河北省秦皇岛市第一医院肿瘤科，河北 秦皇岛 066000；2.河北省秦皇岛市第一医院神经内科，河北 秦皇岛 066000；
    3. 河北省秦皇岛市妇幼保健院妇产科，河北 秦皇岛 066000
  • 出版日期:2017-07-25 发布日期:2017-07-05
  • 作者简介:王芳（1982-），女，河北秦皇岛人，河北省秦皇岛市第一医院主治医师，医学硕士，从事肿瘤内科疾病诊治研究。

Expression of HIF1α and correlated target genes in cervical cancer#br#

  1. 1.Department of Oncology, the First Hospital of Qinhuangdao City, Hebei Province， Qinhuangdao
    066000, China； 2.Department of  Neurology， the First Hospital of Qinhuangdao City, Hebei
    Province， Qinhuangdao 066000, China； 3.Department of Gynaecology and Obstertrics,
    Maternity and Child Care Center of Qinhuangdao City, Hebei Province，
    Qinhuangdao 066000, China
  • Online:2017-07-25 Published:2017-07-05

HTML

PDF (PC)

253

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗检测缺氧诱导因子1α（hypoxia inducible factor1α，HIF1α）及其靶基因葡萄糖转运蛋白1(glucose transporter protein1，GLUT1)和血管内皮生长因子（vascular endothelial growth factor，VEGF）在宫颈癌组织中的表达并分析其临床病理意义。
〖HTH〗方法〖HTSS〗〖KG*2〗选取宫颈癌组织（54例）和正常宫颈上皮组织（10例），采用免疫组织化学SP法检测其HIF1α、GLUT1及VEGF表达的阳性率，并分析HIF1α与GLUT1、VEGF表达的相关性。
〖HTH〗结果〖HTSS〗〖KG*2〗宫颈癌中HIF1α、GLUT1、VEGF阳性表达率高于对照组（P＜005）。有淋巴结转移者宫颈癌组织HIF1α、GLUT1、VEGF表达阳性率高于无淋巴结转移者（P＜005）；中低分化者宫颈癌组织GLUT1表达阳性率高于高分化者；临床分期Ⅲ、Ⅳ期者宫颈癌组织GLUT1表达阳性率高于临床分期Ⅰ期者（P＜005）。HIF1α与GLUT1、VEGF的表达呈正相关（rs=0.280、0.320，P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗HIF1α、GLUT1和VEGF高表达提示宫颈癌具有更高的侵袭性，联合检测可作为评估宫颈癌恶性程度以及预测临床放疗效果的可靠指标。

关键词: 宫颈肿瘤, 缺氧诱导因子1&alpha, 血管内皮生长因子类

Abstract: 〗［Abstract］  Objective〖HTSS〗〓To evaluate the expression of hypoxia inducible factor1α(HIF1α) , glucose transporter protein1(GLUT1) and vascular endothelial growth factor(VEGF) in cervical cancer and to investigate the relationships between their expressions and the clinicopathological characteristics.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The expression levels of HIF1α, GLUT1 and VEGF were detected in 54 cases of cervical cancer by SP immunohistochemieal methods, compared with 10 cases of normal cervical epithelium tissue. The correlation between the expression of HIF1α, GLUT1 and GLUT1，VEGF in cervical cancer was analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive expression rates of HIF1α, GLUT1 and VEGF in cervical cancer tissues were higher than control group(P＜005). The positive expression rates of HIF1α, GLUT1 and VEGF in cervical cancer with lymph node matastasis were significantly higher than those in no lymph node matastasis group(P＜005). The expression of GLUT1 was positively related to lymph node matastasis, histological grades and clinical stages(P＜005). Positive correlation existed between the expression of HIF1α and GLUT1,VEGF in cervical cancer（rs=0.280, 0.320, P＜005）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The high expression of HIF1α, GLUT1 and VEGF shows that the invasion of cervical cancer is even higher. Combined detection of the three indicators can be used to accurately assess the prognosis in cervical cancer and evaluate the clinical effects of radiotherapy.

Key words: uterine cervical neoplasms, hypoxiainducible factor1α, vascular endothelial growth factors

版权所有 © 《河北医科大学学报》编辑部
本系统由北京玛格泰克科技发展有限公司设计开发