深部热疗联合全身化疗治疗晚期卵巢癌的临床效果及对ERCC1、βcatenin及βtubulin Ⅲ表达的影响

doi:10.3969/j.issn.10073205.2018.01.014

河北医科大学学报

深部热疗联合全身化疗治疗晚期卵巢癌的临床效果及对ERCC1、βcatenin及βtubulin Ⅲ表达的影响

山东省菏泽开发区中心医院妇产科，山东菏泽 274000

出版日期:2018-01-25 发布日期:2018-01-05
作者简介:曹华（1978-），女，山东菏泽人，山东省菏泽开发区中心医院主治医师，医学学士，从事妇科疾病诊治研究。

Effects of deep hyperthermia combined with systemic chemotherapy on advanced ovarian cancer and its effect on expression of ERCC1, βcatenin and βtubulin Ⅲ#br#

Department of Gynaecology, Center Hospital of Heze Development Zone, Shandong Province, Heze 274000, China

Online:2018-01-25 Published:2018-01-05

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察深部热疗联合全身化疗治疗晚期卵巢癌的临床效果及对核苷酸切除修复互补基因1（excision repair cross complementing 1，ERCC1）、β链蛋白（βcatenin）及β微管蛋白Ⅲ（βtubulin Ⅲ）表达的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗选取晚期卵巢癌患者80例，按照随机数字表法分为2组，对照组使用紫杉醇联合顺铂化疗，观察组在对照组的基础上进行深部热疗。比较2组临床疗效，静脉血中ERCC1、βcatenin及βtubulin Ⅲ水平，生存率和不良反应发生率。
〖HTH〗结果〖HTSS〗〖KG*2〗观察组肿瘤缓解率和腹腔积液控制率均明显高于对照组， ERCC1和βcatenin的mRNA表达和蛋白含量均明显低于对照组，平均生存时间明显长于对照组，2年后生存率明显高于对照组，胃肠道和骨髓抑制发生率明显低于对照组（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗使用深部热疗联合全身化疗对βtubulin Ⅲ无明显影响，但可有效抑制ERCC1、βcatenin基因的表达，提高治疗效果，减轻不良反应，有效延长患者的生存期并提高患者的生存质量。

关键词: 卵巢肿瘤, 高温, 诱发, 药物疗法

Abstract: ［Abstract］ Objective〖HTSS〗〓To study the clinical efficacy of deep hyperthermia combined with systemic chemotherapy in the treatment of advanced ovarian cancer and the effect on excision repair cross complementing 1(ERCC1), βcatenin and βtubulin Ⅲ expression.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 80 patients with advanced ovarian cancer treated in our hospital from May 2013 to May 2015 were randomly selected. The control group received paclitaxel combined with cisplatin chemotherapy. The observation group was treated with deep hyperthermia on the basis of the control group. The levels of ERCC1, βcatenin and βtubulin Ⅲ in the two groups were statistically analyzed, and the survival rate and adverse reactions were analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The effective rates of tumor remission and ascites control in the observation group were significantly higher than those in the control group. The mRNA and protein levels of ERCC1 and βcatenin in the observation group were significantly lower than those in the control group. The mean survival time of the observation group was significantly longer than that of the control group, and the survival rate of the observation group was significantly higher than that of the control group. The incidence of myelosuppression was significantly lower in the observation group than that in the control group(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The use of deep hyperthermia combined with systemic chemotherapy can effectively inhibit the expression of ERCC1 and βcatenin genes, improve the therapeutic effect, reduce the incidence of adverse reactions, effectively prolong the survival of patients and improve the quality of life of patients.

Key words: ovarian neoplasms, hyperthermia, induced, drug therapy

曹〓华. 深部热疗联合全身化疗治疗晚期卵巢癌的临床效果及对ERCC1、βcatenin及βtubulin Ⅲ表达的影响[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.01.014.

CAO Hua. Effects of deep hyperthermia combined with systemic chemotherapy on advanced ovarian cancer and its effect on expression of ERCC1, βcatenin and βtubulin Ⅲ#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.01.014.

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深部热疗联合全身化疗治疗晚期卵巢癌的临床效果及对ERCC1、βcatenin及βtubulin Ⅲ表达的影响

Effects of deep hyperthermia combined with systemic chemotherapy on advanced ovarian cancer and its effect on expression of ERCC1, βcatenin and βtubulin Ⅲ#br#

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