河北医科大学学报 ›› 2020, Vol. 41 ›› Issue (12): 1432-1435,1459.doi: 10.3969/j.issn.1007-3205.2020.12.015

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SMILE来源的人角膜基质透镜在角膜溃疡中的应用分析

  

  1. 1.四川省绵阳市万江眼科医院眼表角膜病科，四川 绵阳 615000；2.四川省广元市万江眼科医院屈光及白内障科，
    四川 广元 628000；3.华西医院屈光及眼表科，四川 成都 610044
  • 出版日期:2020-12-25 发布日期:2021-01-04
  • 作者简介:冯梅（1974-），女，四川江油人，四川省绵阳市万江眼科医院主治医师，从事眼表疾病诊治研究。

Application of SMILE human corneal stromal lens in corneal ulcer

  1. 1.Department of  Ophthalmic ，Keratopathy, Wanjiang Eye Hospital, Sichuan Province, Mianyang 
    615000, China; 2.Department of Refractive and Cataract， Guangyuan Wanjiang Eye Hospital, 
    Sichuan Province, Guangyuan 628000, China; 3.Department of Refractive and Eye Table, 
    Sichuan West China Hospital, Sichuan Province, Chengdu 610044, China
  • Online:2020-12-25 Published:2021-01-04

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摘要： 目的 分析飞秒激光小切口角膜基质透镜取出术（femtosecond laser small incision lenticule extraction，SMILE）来源的人角膜基质透镜在角膜溃疡中的应用效果。
方法 选取75例角膜溃疡患者为主要研究对象，随机分为观察组（38例）与对照组（37例）。对照组采取黏合剂联合多层生物羊膜填塞加羊膜移植，观察组采取SMILE来源的人角膜基质透镜联合羊膜移植术治疗。观察2组患者的治疗效果，同时比较2组患者术后视力状况差异，最后统计2组术后并发症发生率。
结果 观察组总有效率为97.37%，明显高于对照组的83.78%（P＜005）；2组术后视力状况比较差异无统计学意义（P＞0.05）。观察组术后并发症发生率为2.63%,明显低于对照组的18.92%（P＜0.05）。
结论 SMILE来源的人角膜基质透镜在角膜溃疡中具有较好的治疗效果，能够有效改善患者的术后视力状况，且有较高的安全性，值得推广使用。


关键词: 角膜溃疡, 角膜基质, 治疗结果

Abstract: Objective To analyze the effect of human corneal stroma lens from femtosecond laser small incision lenticule extraction（SMILE）sources in corneal ulcer. 
Methods Seventy-five patients with corneal ulcer were selected as the main subjects.It was randomly divided into observation group(38 cases) and control group(37 cases). SMILE source of human corneal stroma lens combined with amniotic membrane transplantation was used in the observation group. To observe the therapeutic effect of the two groups, At the same time, the difference of visual acuity between two groups was compared, and the incidence of postoperative complications was calculated. 
Results The total effective rate in the observation group was 97.37%, which was significantly higher than that in the control group(P＜0.05). After operation, the difference of visual acuity were not statistically significant between two groups(P＞0.05). After operation, the incidence of postoperative complications was 2.63% in the observation group, which was significantly lower than that in the control group(P＜0.05). 
Conclusion Human corneal stromal lens from SMILE sources has good therapeutic effect in corneal ulcer, can effectively improve the postoperative visual condition of patients, and has high safety, which is worth popularizing.

Key words: corneal ulcer, treatment outcome； corneal stroma 

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