新型口服剂型抗凝药物在老年人颈椎单开门术后的应用

doi:10.3969/j.issn.1007-3205.2021.02.006

河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (2): 150-153.doi: 10.3969/j.issn.1007-3205.2021.02.006

新型口服剂型抗凝药物在老年人颈椎单开门术后的应用

河北省邯郸市中心医院东区骨一科，河北邯郸 056008

出版日期:2021-02-25 发布日期:2021-03-09
作者简介:江丽强（1982-），男，河北邯郸人，河北省邯郸市中心医院主治医师，医学硕士，从事脊柱、创伤疾病诊治研究。
基金资助:
邯郸市科学技术研究与发展计划项目（1823208035ZC）

The application of a new oral form of anticoagulant in senior citizens with cervical expansive open-door laminoplasty

The First Department of Orthopedics, East District of Handan Central Hospital, Hebei Province, Handan 056008, China

Online:2021-02-25 Published:2021-03-09

摘要/Abstract

摘要： 目的探讨利伐沙班对老年人颈椎单开门术后预防性应用药物抗凝的有效性和安全性。
方法回顾性研究年龄≥60岁接受颈椎后路单开门椎管扩大成形术治疗的患者87例，根据术后预防血栓方法分为利伐沙班组（47例）和对照组（40例），利伐沙班组采用利伐沙班抗凝治疗，对照组未采用药物抗凝。比较2组手术时间、术中出血量、围手术期输血率、切口引流量、术后出血和静脉血栓栓塞症(venous thromboembolism，VTE)发生率。
结果 2组手术时间、术中出血量、围手术期输血率、术后引流量、术后出血发生率差异均无统计学意义（P＞0.05），利伐沙班组VTE发生率低于对照组，差异有统计学意义（P＜0.05）。
结论利伐沙班显著降低了老年人颈椎单开门术后VTE发生率，避免了相应的出血风险，是颈椎单开门术后安全可靠的预防性抗凝药物。

关键词: 颈椎, 单开门术式, 利伐沙班

Abstract: Objective To investigate the efficacy and safety of rivaroxaban as prophylactic anticoagulant therapy after cervical expansive open-door laminoplasty in senior citizens.
Methods A retrospective study was performed on 87 patients aged ≥60 years who received posterior expansive open-door laminoplasty for cervical spine. The parients were divided into rivaroxaban group(n=47) and control group(n=40) according to postoperative thrombosis prevention methods. Rivaroxaban group received rivaroxaban as anticoagulation therapy, while the control group did not receive anticoagulation therapy. Duration of operation, intraoperative blood loss, perioperative blood transfusion rate, incision drainage, postoperative hemorrhage, and incidence of venous thromboembolism(VTE) were compared between two groups.
Results There were no statistically significant differences in duration of operation, intraoperative blood loss, perioperative blood transfusion rate, postoperative drainage, and incidence of postoperative hemorrhage between two groups(P＞0.05). The incidence of VTE in the rivaroxaban group was lower than that in the control group, with statistically significant differences(P＜0.05).
Conclusion Rivaroxaban significantly reduces the incidence of VTE after cervical expansive open-door laminoplasty in senior citizens, while avoiding the corresponding risk of bleeding. Therefore, rivaroxaban is a safe and reliable preventive anticoagulant after cervical expansive open-door laminoplasty.

Key words: cervical spine, expansive open-door laminoplasty, rivaroxaban

江丽强. 新型口服剂型抗凝药物在老年人颈椎单开门术后的应用[J]. 河北医科大学学报, 2021, 42(2): 150-153.

JIANG Li-qiang. The application of a new oral form of anticoagulant in senior citizens with cervical expansive open-door laminoplasty[J]. Journal of Hebei Medical University, 2021, 42(2): 150-153.

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新型口服剂型抗凝药物在老年人颈椎单开门术后的应用

The application of a new oral form of anticoagulant in senior citizens with cervical expansive open-door laminoplasty

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