关键词: 卒中, 尿酸, 总抗氧化能力, 丙二醛

Abstract: ［Abstract］  Objective〖HTSS〗〓To investigate the correlation of uric acid, total antioxidant capacity(TAC）, malondialdehyde(MDA) and clinical prognosis in patients with ischemic stroke.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 162 acute ischemic stroke patients were included. The general clinical data, the total antioxidant capacity, superoxide dismutase, malondialdehyde, uric acid levels were collected. At 14 days, the scores of modified Rankin Score>2(mRS>2) was defined as poor prognosis and mRS≤2 points was defined as excellent outcome.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The history of diabetes, previous stroke or transient ischemic stroke(TIA) incidence of poor outcome group was higher than that of the good outcome group, diastolic blood pressure, uric acid, TAC, triglyceride and high density lipoprotein(HDL) level were lower than that in the good outcome group, MDA and fasting blood glucose levels are higher than good outcome group, the difference was statistically significant(P<0.05). Logistic regression analysis showed that past stroke or TIA history, MDA was an independent risk factor for ischemic stroke, and uric acid, HDL, and TAC were prognostic factors. Uric acid level was positively correlated with TAC and prognosis, which was negatively correlated with MDA.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The patients with higher levels of uric acid level has lower level of oxidative stress, and better clinical prognosis.

Key words: stroke； uric acid； total antioxidant capacity, malondialdehyde