负压吸引联合前列地尔及依帕司他治疗糖尿病足部溃疡的临床研究

doi:10.3969/j.issn.1007-3205.2020.05.009

河北医科大学学报

负压吸引联合前列地尔及依帕司他治疗糖尿病足部溃疡的临床研究

河北省第七人民医院骨二科，河北定州 073000

出版日期:2020-05-25 发布日期:2020-06-04
作者简介:张亮(1983-)，男，河北定州人，河北省第七人民医院主治医师，医学硕士,从事骨科疾病诊治研究。
基金资助:
河北省医学科学研究重点课题（20180965）

Clinical study of vacuum suction therapy combined with Alprostadil and Apalstat in the treatment of diabetic foot ulcers

Second Department of Orthopaedics， the Seventh People′s Hospital of Hebei Province， Dingzhou 073000， China

Online:2020-05-25 Published:2020-06-04

摘要/Abstract

摘要： ［摘要］
目的研究负压吸引联合前列地尔及依帕司他治疗糖尿病足部溃疡(diabetic foot ulcers,DFU)的临床效果。
方法选取DFU患者54例。根据随机数字表法分为对照组和观察组各27例。2组均采用常规治疗方案。对照组采用负压吸引联合前列地尔治疗；观察组采取负压吸引联合前列地尔及依帕司他治疗。比较2组患者治疗后创面缩小率、创面肉芽组织覆盖率，创面肉芽组织生长厚度、创面细菌清除率及创面愈合时间。
结果 2组创面缩小率均呈明显升高趋势，观察组创面缩小率高于对照组，组间、时点间、组间·时点间交互作用差异有统计学意义（P＜0.01）。观察组创面肉芽组织覆盖率、肉芽组织生长厚度、细菌清除率均明显高于对照组，差异有统计学意义（P＜0.01）。观察组创面愈合时间短于对照组（P＜0.01）。
结论负压吸引联合前列地尔及依帕司他治疗DFU患者效果显著，缩短溃疡愈合时间。

关键词: 糖尿病足, 溃疡, 前列地尔, 依帕司他

Abstract: ［Abstract］Objective〖HTSS〗To evaulate the clinical efficacy of vacuum sealing drainage combined with Alprostadil and Apalstat in the treatment of diabetic foot ulcers(DFU).
〖WTHZ〗Methods〖HTSS〗Fifty-four patients with DFU were admitted to our research. According to random number table method, 27 cases were divided into control group and observation group. Routine treatment was adopted to both groups. Among them, patients in the control group were treated with vacuum sealing drainage combined with Alprostadil; patients in the observation group were treated with vacuum sealing drainage combined with Alprostadil and Apalstat. The reduction rate of wound,the cover rate of granulation tissue,the thickness of granulation tissue,the clearance rate of bacteria and the healing time of the wound were compared between two groups after treatment.
〖WTHZ〗Results〖HTSS〗In both groups the reduction rates of wound were increased significantly, and in observation group it was higher than that in the control group. And all of the difference between two groups at all time point were statistically significant(P＜0.01). The growth thickness, coverage rate and bacterial clearance rate of granulation tissue in the observation group were higher than those in the control group, and the difference was statistically significant(P＜0.01). The wound healing time of the observation group was lower than that of the control group(P＜0.01).
〖WTHZ〗Conclusion〖HTSS〗Vacuum sealing drainage combined with Alprostadil and Apalstat in the treatment of DFU patients has a significant effect and shortens the healing time of ulcers.

Key words: diabetic foot, ulcer, alprostadil, eapalst

张亮，张继春，庞子轩，王玉冰. 负压吸引联合前列地尔及依帕司他治疗糖尿病足部溃疡的临床研究[J]. 河北医科大学学报, doi: 10.3969/j.issn.1007-3205.2020.05.009.

ZHANG Liang， ZHANG Ji-chun， PANG Zi-xuan， WANG Yu-bing. Clinical study of vacuum suction therapy combined with Alprostadil and Apalstat in the treatment of diabetic foot ulcers[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.1007-3205.2020.05.009.

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负压吸引联合前列地尔及依帕司他治疗糖尿病足部溃疡的临床研究

Clinical study of vacuum suction therapy combined with Alprostadil and Apalstat in the treatment of diabetic foot ulcers

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