河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (6): 641-645.doi: 10.3969/j.issn.1007-3205.2021.06.005

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联合检测hs-CRP、Hcy和凝血功能对急性脑梗死病情严重程度的评估价值分析

  

  1. 1.安徽省蚌埠市第一人民医院检验科，安徽 蚌埠 233000;2.安徽省蚌埠市妇幼保健院检验科，安徽 蚌埠 233000
  • 出版日期:2021-06-25 发布日期:2021-07-05
  • 作者简介:陈灏（1983-），男，安徽淮南人，安徽省蚌埠市第一人民医院主管检验师，医学学士，从事凝血检验研究。
  • 基金资助:
    安徽省卫生计生委科研计划项目（2018AHQK061）

Value of combined detection of  hs-CRP, Hcy and blood coagulation function in evaluating the severity of acute cerebral infarction

  1. 1.Department of Clinical Laboratory, the First People's Hospital of Bengbu, Anhui Province, 
    Bengbu 233000, China; 2.Department of Clinical Laboratory, Maternal and Child Health 
    Care Hospital of Bengbu, Anhui Province, Bengbu 233000, China
  • Online:2021-06-25 Published:2021-07-05

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摘要： 目的  分析联合检测超敏C反应蛋白（hypersensitive C-reactive protein，hs-CRP）、同型半胱氨酸（homocysteine，Hcy）和凝血功能对急性脑梗死病情严重程度的评估价值。
方法  选取106例急性脑梗死患者（病例组），根据患者发病96 h内有无神经功能症状进行性加重，分为进展组（50例）和未进展组（56例），并同期选择体检健康者45例作为对照组。比较各组血清hs-CRP、Hcy、血脂代谢和凝血功能的情况。
结果  各组血清hs-CRP、Hcy、血脂代谢和凝血功能指标差异有统计学意义（P＜0.05）。病例组血清hs-CRP、Hcy、总胆固醇（total cholesterol，TC）、三酰甘油（triglyceride，TG）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol，LDL-C）、D-二聚体、纤维蛋白原（fibrinogen，Fib）水平较对照组明显增加（P＜0.05），病例组高密度脂蛋白胆固醇（high density liptein cholesterol，HDL-C）水平较对照组明显下降（P＜0.05）。进展组血清hs-CRP、Hcy、TC、TG、LDL-C、D-二聚体、Fib水平较未进展组明显升高（P＜0.05），进展组HDL-C水平较未进展组明显下降（P＜0.05）。
结论  急性脑梗死患者可存在明显的凝血功能和血脂代谢障碍，并且处于进展期的患者血清hs-CRP、Hcy、TC、TG、LDL-C、Fib及D-二聚体水平明显升高，HDL-C水平明显下降，这对判断急性脑梗死患者病情的严重程度具有一定的评估价值。


关键词: 脑梗死, C反应蛋白质, 同型半胱氨酸

Abstract: Objective  To analyze the value of combined detection of hypersensitive C-reactive protein(hs-CRP), homocysteine(Hcy) and blood coagulation function in evaluating the severity of acute cerebral infarction(ACI). 
Methods   A total of 106 patients with ACI were enrolled as the case group, and were divided into progression group(n=50) and non-progression group(n=56) according to presence or absence of progressive aggravation of the neurological symptoms within 96 hours of onset of the disease. In the meantime, 45 healthy persons who underwent physical examination were selected as control group. The serum hs-CRP, Hcy, lipid metabolism and blood coagulation function were compared in each group. 
Results  There were significant differences in serum hs-CRP, Hcy, lipid metabolism and blood coagulation function indexes in each group(P＜0.05). The levels of serum hs-CRP, Hcy, total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C), and D-dimer(DD) and fibrinogen(Fib) were significantly higher in the case group than in the control group(P＜0.05), while the level of high-density lipoprotein-cholesterol(HDL-C) was significantly lower in the case group than in the control group(P＜0.05). The levels of serum hs-CRP, Hcy, TC, TG, LDL-C, DD, and Fib in the progression group were significantly higher than those in the non-progression group(P＜0.05), whereas the level of HDL-C in the progression group was significantly lower than that in the non-progression group(P＜0.05). 
Conclusion  The patients with ACI may have obvious coagulation dysfunction and dyslipidemia. The levels of serum hs-CRP, Hcy, TC, TG, LDL-C, Fib and DD in patients with ACI in the progression group are remarkably increased, while the level of HDL-C is significantly decreased, which is of certain value in evaluating the severity of ACI.


Key words: infarction, C-reactive protein, homocysteine

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