关键词: 肺疾病, 慢性阻塞性, 炎症, 氧化应激

Abstract: Objective To investigate the expression of stanniocalcin 1(STC1), tumor necrosis factor-like weak inducer of apoptosis(TWEAK), and microRNA(miRNA)-183 in patients with chronic obstructive pulmonary disease(COPD) and their correlation. 
Methods In total, 114 COPD patients were selected as the COPD group, and divided into severe(n=23), moderate(n=48) and mild(n=43) groups according to the degree of airflow restriction, and divided into death(n=22) and survival(n=92) groups according to the prognosis. Another 63 healthy people undergoing physical examination during the same period were selected as the control group.The lung function ［forced expiratory volume in one second(FEV1), FEV1/forced vital capacity(FVC)］of the subjects was examined, and the levels of serum STC1, TWEAK, miR-183, malondialdehyde(MDA), superoxide dismutase(SOD), interleukin(IL) 6 and IL-8 were determined. Pearson correlation analysis was used to analyze the correlation between serum STC1, TWEAK, miR-183 levels and lung function and serum MDA, SOD, IL-6, and IL-8 levels in COPD group. The ROC curve was used to analyze the predictive value of serum STC1, TWEAK, and miR-183 levels in the poor prognosis of COPD patients. 
Results Compared with the control group, FEV1, FEV1/FVC and serum STC1, SOD levels in the COPD group were significantly reduced, while the levels of TWEAK, miR-183, MDA, IL-6, and IL-8 were significantly increased(P＜0.05).Serum STC1 and SOD levels in the mild, moderate and severe groups decreased sequentially, while the levels of TWEAK, miR-183, MDA, IL-6, and IL-8 increased sequentially(P＜0.05). Serum STC1 levels in the COPD group were positively correlated with FEV1, FEV1/FVC, and SOD, and negatively correlated with MDA, IL-6, and IL-8(P＜0.05). TWEAK and miR-183 levels were negatively correlated with FEV1, FEV1/FVC, and SOD, and positively correlated with MDA, IL-6, and IL-8(P＜0.05). The area under ROC curve (AUC) of STC1+TWEAK+miR-183(AUC=0.919, 95%CI: 0.853-0.862) in predicting poor prognosis of COPD patients was significantly greater than that of STC1(AUC=0.796, 95%CI: 0.710-0.866), TWEAK(AUC=0.788, 95%CI: 0.702-0.859), and miR-183(AUC=0.798, 95%CI: 0.713-0.868) alone(P＜0.05).
Conclusion The serum STC1 level of patients with COPD decreases, and the levels of TWEAK and miR-183 increase. It may be involved in the progression of COPD through oxidative stress and inflammation, which can be used as predictors of poor prognosis for patients.

Key words: pulmonary disease, chronic obstructive, inflammation, oxidative stress