Abstract: [ Abstract ] Objective Toinvestigatetheeffectsofdifferentdosesofketamineonrocuronium
inducedinjectionpainandhemodynamicresponseduringanesthesiainduction.Methods One
hundredandsixtycasesoftrachealintubationpatientswererandomlydividedintofourgroups :
normalsaline2 mL ( group A ), injection0.1 mg / kgketamine2 mL ( groupB ), 0.2 mg /
kg
ketamine2 mL ( groupC ), 0.3 mg / kgketamine2 mL ( group D ) .Afterpretreatmentwith
experimentaldrugbydoubleblindedmethods , 10mgofrocuronium wasthenadministered30s
later.Thepainseveritywasscoredaccordingtothescaleoffourpointchiarella.Hemodynamic
parameterswerethencollectedatbaselineat0 min , 1 min , 2 minfollowinginjectionofall
anesthetics , aswellasat0 min , 1 min , 3 minaftertrachealintubation.Results Therewas
significantdifferenceintheincidenceofinjectionpainbetweenthe4groups ( P <0.01 ) .The
incidenceofinjectionpainingroupCandgroupDwassignificantlylowerthanthatingroupA
(
P <0.05 ) .TheincidenceofinjectionpainingroupDwassignificantlylowerthanthatingroup
B ( P <0.05 ) .The4groupsofpatientswith MAP , SBP , DBP werefirstdecreasedandthen
increased.HRshowedagraduallyincreasingtrend.Andwiththeincreaseofthedosageofthe drug , thechangerangewassignificantlydecreased.Thereweresignificantdifferencesinthe
interactionbetweenthegroups , thetimepointandthetime between groups ( P <0.05 ) .
Conclusion Pretreatmentwithketaminecanrelievetheinjectionpaininducedbyrocuronium
dosage-dependently.Withtheincrease ofthe dose , hemodynamics was morestable , side
reactionswasless.Itisworthyofclinicalapplication.

Key words: pain, ketamine, rocuronium