Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the relationship between polymorphism of vitamin D receptor（VDR） gene(including Apa1, Taq1) and susceptibility of squamous cell carcinoma of lung cancer(SCC).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The blood samples were collected from 288 patients with SCC and 284 healthy individuals. Leukocyte DNA from peripheral blood was extracted. The method of polymerase chain reactionrestriction fragment length polymorphism(PCRRFLP) was applied to test the genotype of Apa1, Taq1 in VDR gene.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓VDR Taq1 gene polymorphisms is the risk factor of SCC. The SCC risk of tt+Tt genotype carriers is 0.556 times than the TT genotype carriers(OR=0.556， 95%CI=0.393-0.785). Based on stratification analysis of smoking: In smoking group, there is statistical significance in Taq1 gene polymorphisms. The SCC risk of tt+Tt genotype carriers is 0.049 times than the TT genotype carriers(OR=0.049， 95%CI=0.259-0.929). There is statistical significance in t allele and T allele. The SCC risk of t allele carriers is 0.444 times than the T allele carriers(OR=0.444， 95%CI=0.241-0.817).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Taq1 polymorphism is related to genetic susceptibility of SCC. The tt+Tt gene reduces the risk of SCC. The t allele is negatively correlated with the risk of SCC. Smokers with tt+Tt gene are significantly reduced the risk of SCC.

Key words: lung neoplasms, vitamin D, gene