The expression and clinical significance of AMPKACC signaling pathway in papillary thyroid cancer

doi:10.3969/j.issn.10073205.2016.11.008

Abstract

Abstract: [ Abstract ] Objective Toinvestigatetheexpression and significance of AMPK-ACC
signalingpathwayinpapillarythyroidcancer ( PTC ) bystudyingtheexpressionofphosphorylated
AMP-activatedproteinkinase ( pAMPK ) andphosphorylatedacetyl-CoAcarboxylase ( pACC ) in
tissuesofPTCandtheirrelationstotheclinicopathologicalfeatures.Methods Theexpressionof
pAMPKandpACCintissuesof60casesofPTCand20casesofnodulargoiterweredetectedby
immunohistochemicaland westernblot , andtherelationship withage , gender , tumorsize ,
bilateral , multifocal , capsularinvasion , lymphnode metastasis wasanalyzed.Results The
expressionofpAMPKandpACCintissuesofPTCwassignificantlyhigherthanthatinnodular
goitertissues ( P <0.05 ) .TheexpressionofpAMPKandpACCincentrallymphaticmetastasesof
PTCwassignificantlyhigherthanthatinPTCwithoutcentrallymphaticmetastases ( P <0.05 ) .
TheexpressionofpAMPKandpACCinlaterallymphaticmetastasesofPTCwassignificantly higherthanthatinPTCwithoutlaterallymphaticmetastases ( P <0.05 ) .Age , gender , tumor
size , bilateralcarcinoma , multifocalandcapsularinvasionwerenotrelatedtotheexpressionof
pAMPKandpACCin PTC ( P >0.05 ) .WesternblotdetectionshowedpAMPK andpACC
expressionsinPTCtissueweresignificantlyhigherthaninnodulargoiter ( P <0.05 ) .Conclusion
pAMPKandpACCaresignificantlyup-regulatedinPTC , andtheincreaseddegreewasclosely
relatedtonecklymphnodemetastasis.Theac

Key words: thyroid neoplasms, lymph nodes, gene expression regulation, enzymologic

YAN Li1, LI Qinghuai1, JI Hong1, SHEN Wei1, GUO Hao1, WANG Changquan2. The expression and clinical significance of AMPKACC signaling pathway in papillary thyroid cancer[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.11.008.

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The expression and clinical significance of AMPKACC signaling pathway in papillary thyroid cancer

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