Studies on the acute and chronic toxicity test of dl3nbutylphthalide in mice

doi:10.3969/j.issn.10073205.2016.11.003

Journal of Hebei Medical University

Previous Articles Next Articles

Studies on the acute and chronic toxicity test of dl3nbutylphthalide in mice

(
1. DepartmentofCardiology , theSecondHospitalofHebeiMedicalUniversity , Shijiazhuang
050000 , China ; 2. DepartmentofNeurology , HebeiGeneralHospital , Shijiazhuang
050051 , China ; 3. DepartmentofNoveltySearch , HebeiMedicalScienceand
InformationResearchInstitute , Shijiazhuang 050071 , China

Online:2016-11-25 Published:2016-12-14

Abstract

Abstract: [ Abstract ] Objective To explore the acute toxicity and chronictoxicity of dl-3-n-
butylphthalide ( NBP ) inmice.Methods TheBlissmethodwasusedtoobservetheacutetoxic
symptomsandtoobtainthetoxicparametersmediallethaldose ( LD50 ) ofNBPinmice.Repeated
administrationoftailveinfor30days , andthelong-termtoxicitytomicewasobserved.NBPis
dividedintolow , mediumandhighdosegroup ( 40 , 80and160mg / kgrespectvely ), normalsaline
wasusedascontrolgroup.Thechangesofthebloodchemistry ( alaninetransaminase , aspartate
aminotransferase , bloodureanitrogen , serumcreatinine ), andhistopathologywereexamined.
Results TheLD50valueoftheNBPwas545. 1mg / kg.Theelevatingtendencyofthelevelsof
aspartateaminotransferasewasobservedinthehighdosegroupofNBP.Nosignificantchanges
wereobservedinclinicalsigns , otherbloodchemistry , andhistopathology.Conclusion The
rationaluseofNBPwillnothaveadverseeffectsonthetargetanimal.

Key words: toxicity tests, dl3nbutylphthalide, mice

TIAN Xiaochao1, HE Weiliang2, LIU Siwen3, Yang Rong1, LIU Suyun1*. Studies on the acute and chronic toxicity test of dl3nbutylphthalide in mice[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.11.003.

[1]	SUN Mengjun1， GUO Jianmei2， ZHOU Gengsu3， DONG Zefei4， ZHENG Chungui3， CAO Cuili5*. In vitro culture and identification of neural stem cells in ICR mice#br# [J]. Journal of Hebei Medical University, 2019, 40(3): 258-262.
[2]	LIU Mingfeng1, YANG Jinxia2, LIU Xiao2, QI Jinlong2*, JIA Qingzhong2. Effect study of XueSuSheng granule on animal anemia model#br# [J]. Journal of Hebei Medical University, 2018, 38(7): 822-827.
[3]	LIU Aining1， YANG Wengang1, JU Shuhong1, SUN Yiming1, MA Jun2, ZHOU Hui3*. Influence of differnce doses of rosuvastatin and folic acid on the expression of atherosclerosis related gene for hyperhomocysteinemia mice#br# [J]. Journal of Hebei Medical University, 2018, 38(4): 378-382.
[4]	GONG Miao1, ZHANG Lei1, ZHAO Chunfang1, LI Li1, ZHANG Yanan1, REN Guangwei2*. Protective effect and mechanism of probucol on renal ischemiareperfusion injury in mice#br# [J]. Journal of Hebei Medical University, 2017, 37(5): 497-500,505.
[5]	HU Cai-xia1, FENG Jia2, LV Li-jing1, GAO Shun-qiang1, WANG Wen-qing1, ZHANG Guo-qiang1*. Effects of 2-Methoxyestradiol on growth, invasion and migration of malignant melanoma B16cells [J]. Journal of Hebei Medical University, 2016, 37(4): 407-411.
[6]	HU Cai-xia1, JIANG Shao-qian1, ZHANG Guo-qiang1, FENG Jia2, TIAN Fei3, GAO Shun-qiang1*. Inhibitioneffectsof2-methoxyestradiolonmelanomaxenografttumorinvivo [J]. Journal of Hebei Medical University, 2016, 37(3): 289-292.
[7]	GONG Miao,ZHANGLei 1,ZHAOYu 1,YINQing 1,GUOQian-yu 1,RENGuang-wei 2*. Establishmentofculturesystemofmousespermatogeniccellsinvitrowithoutserum [J]. Journal of Hebei Medical University, 2016, 37(1): 1-4.
[8]	CUI Zhao-ling;HUANG Xiang-hua;GONG Xin-peng. LU Su-yu;LI Zhe;MU Lin;WU Xiao-lei;LI Shao-mei;FU Shu-xia [J]. , 2015, 36(10): 1162-1162.

Studies on the acute and chronic toxicity test of dl3nbutylphthalide in mice

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 8

Recommended Articles

Metrics

Comments