Abstract: Objective To assess the diagnostic value of combined detection of tumor markers carcinoembryonic antigen( CEA),carbohyrate antigen 19-9( CA19-9 ) and inflammatory marker C reactive protein( CRP)in colon cancer. Methods Serum levels of CEA,CA199 and CA125 were determined in 146 patients with colorectal cancer,158 patients with inflammatory bowel disease,colon polyp or acute appendicitis,and 76 healthy persons. And their accuracies and consistencies with the analysis of receive operating characteristic(ROC)and value of Kappa were evaluated. Results Compared with the control group,the serum CRP,CA19-9 and CEA in patients with colon cancer and inflammatory bowel disease were significantly increased. The levels of CEA and CA19-9 in colon cancer group were obviously higher than those of inflammatory bowel disease group and control group. ROC was used to compare the diagnostic value of CEA,CA19-9 and CRP in discriminating benign inflammatory and colon cancer groups,indicating the diagnostic value of CRP was better than that of CEA and CA19-9. The AUC of combined detection of CEA,CA19-9 and CRP was 0. 886. Conclusion Combined detection of CEA, CA199 and CRP can help improve the diagnosis accuracy of colorectal cancer. The diagnostic accuracy was superior to individual item.

Key words: colorectal neoplasms, carcinoembryonic antigen, carbohydrate antigen 19-9(CA19-9), C-reactive protein