Abstract: Objective To investigate the bacteria distribution of neonatal purulent meningitis,antibiotic sensitivity and resistance,and provide laboratory evidence for clinical diagnosis and treatment.Methods Twenty-eight cases diagnosed purulent meningitis were recruited into this study.The bacterial culture,drug resistance and sensitivity of cerebrospinal fluid from the patients were analyzed.Results The pathogen distribution in the cerebrospinal fluid of 28 cases with neonatal purulent meningitis:27 cases with cultured single strain,just 1 case with two strains.In this findings,there were 20 gram-negative bacteria strains (68.96%),8 gram-positive bacteria strains (27.59%),1 candida albicans strain (3.45%).The drug resistant rate of gram-negative bacteria to ampicillin,cotrimoxazole,piperacillin was more than 80.00%;on the other hand,it was up to 60.00% to cefazolin,tetracycline,cefotaxime.Eight strains of extended spectrum beta lactamase bacteria were tested in this study.Gram-negative bacteria resistant to meropenem and amikacin were not detected.Most gram-positive bacteria showed drug resistance to ampicillin,cotrimoxazole,erythromycin,cefoxitin.There was none detected in gram-positive bacteria resistant to vancomycin.Conclusion Gram-negative bacteria was the major pathogens in neonatal purulent meningitis,and they were resistant to multiple antibiotics.

Key words: meningitis, bacterial infection, drug resistance