Abstract: Objective To explore the clinical application value of early microecological treatment with golden bifid on the applying of intubation-surfactant-extubation(INSURE)for premature infants.Methods Eighty-six premature infants with respiratory distress syndrome (RDS)treated by applying INSURE were randomly divided into two groups.Patients of both groups were subjected to routine treatments.Besides,patients of the treatment group were given live combined Bifidobacterium and Lactobacillus tablets,0.5 g,3 times/day.Results There were significant differences in the incidence of feeding intolerance(χ2 =4.693,P <0.05),enough feeding time(t = 2.385,P < 0.05 ),the number of warm brine enema(t = 2.925,P < 0.05 ),birth mass recovery time(t =4.541,P <0.05),and incidence of cholestasis(χ2 =4.671,P < 0.05).But,there were no significant differences in the incidence of necrotizing enterocolitis.The probiotics was not related to the occurrence of sepsis.Conclusion The premature infants with RDS treated by INSURE strategy benefit the implementation of early microecological treatment over to the full amount feeding by gastrointestinal tract,better growth weight,reduce cholestasis occurrence,no side effect was found.It is worth clinical promotion.

Key words: respiratory distress syndrome, newborn, intermittent positive-pressure ventilation, biological agents