Abstract: ［Abstract］  Objective〖HTSS〗〓To evaluate the curative effect of peripheral vein transplant human umbilical cord mesenchymal stem cells on patients with hepatitis B liver cirrhosis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty patients with hepatitis B liver cirrhosis were equally divided into treatment group and control group. The treatment group was given umbilical cord mesenchymal stem cell transplantation on the basis of comprehensive medical treatment and the control group was adapted with the comprehensive medical treatment. The changes of biochemical indexes, clinical symptoms and the occurrence of adverse reactions at 2, 4, 12 and 24 weeks before and after treatment were observed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After 4week treatment, the improvement rate of fatigue, abdominal distension, appetite and ascites in the treatment group were higher than that in the control group and the differences have statistical significance(P＜005). With time extension, alanine aminotransferase, aspartate aminotransferase and total bilirubin of the two groups were decreased, there was significant difference of time dissimilarity between two groups(P＜005), but there were no significant differences of interblock and interaction of interblock with time dissimilarity between two groups(P＞005). The albumin, cholinesterase and prothrombin activity showed an increasing trend and there were significant differences of time dissimilarity and interaction of interblock with time dissimilarity between two groups(P＜005), but there was no significant difference of interblock between two groups(P＞005). There were no suffered severe complications and adverse reactions in all groups.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Human umbilical cord mesenchymal stem cell transplantation via peripheral vein in the treatment of hepatitis B liver cirrhosis is safe and effective.

Key words: liver cirrhosis, hepatitis Ｂ, mesenchymal stem cell transplantation