Abstract: Objective To investigate the correlation and significance of brainstem auditory evoked potentials (BAEP) and cerebral blood flow (CBF) in patients with epilepsy secondary to cerebral infarction. 
Methods A total of 80 patients with epilepsy secondary to cerebral infarction were selected as the research group, and another 80 patients without epilepsy secondary to cerebral infarction during the same period were selected as the control group. The general information, CBF, serum lipoprotein-associated phospholipase A2 (Lp-PLA 2), neuron-specific enolase (NSE) levels and BAEP scores at admission were compared between two groups. The BAEP scores of patients with different epileptic characteristics (seizure type, discharge type, discharge site) in the research group were compared, and the correlation between BAEP scores and CBF, serum Lp-PLA2, and NSE levels in patients with epilepsy secondary to cerebral infarction was analyzed, and BAEP scores in patients with different characteristics of epilepsy secondary to cerebral infarction were compared. The correlation between BAEP score and the characteristics of epilepsy secondary to cerebral infarction was analyzed, and the value of BAEP scores, CBF, Lp-PLA2, and NSE in predicting epilepsy secondary to cerebral infarction was analyzed by receiver operating characteristic (ROC) curve. 
Results CBF was lower in the research group than in the control group, while serum Lp-PLA2 and NSE levels and BAEP scores were higher than those in the control group (P＜0.05). BAEP scores were negatively correlated with CBF and positively correlated with serum Lp-PLA2 and NSE levels in the research group (P＜0.05). BAEP scores were higher in patients with generalized seizures than in patients with partial seizures in the research group, and BAEP scores were higher in patients with multifocal discharge than in focal discharge patients (P＜0.05). BAEP scores were positively correlated with seizure type and discharge type in patients with epilepsy secondary to cerebral infarction (P＜0.05). The area under the curve (AUC) of BAEP scores, CBF, Lp-PLA2, and NSE in predicting epilepsy secondary to cerebral infarction was > 0.7, in which BAEP scores combined with CBF, Lp PLA2, and NSE in prediction had the largest AUC of 0.928 (95%CI: 0.876-0.963). 
Conclusion BAEP in patients with epilepsy secondary to cerebral infarction is closely correlated with CBF and serum Lp-PLA2 and NSE levels, and the combination of the indicators has high predictive efficacy in predicting epilepsy secondary to cerebral infarction.

Key words: cerebral infarction, epilepsy, brainstem auditory evoked potentials