Abstract: Objective To investigate the perioperative analgesic effect of stellate ganglion block combined with epidural block using low-concentration ropivacaine in patients with ovarian cancer undergoing radical resection. 
Methods A total of 118 ovarian cancer patients admitted to the Third Hospital of Shandong Province were selected and divided into research group (n=59) and control group (n=59) by random number table method. All patients underwent radical resection of ovarian cancer and were given general intravenous anesthesia. The control group received epidural block using low-concentration ropivacaine before surgery, while the research group received stellate ganglion block combined with epidural block using low-concentration ropivacaine (planetary ganglion block before epidural block). Postoperative analgesia, visual analog scale (VAS) score, hemodynamics ［heart rate (HR), mean arterial pressure (MAP)］, stress response ［cortisol (Cor) and adrenocorticotropin (ACTH)］, immune function ［CD3+, CD4+, natural killer cells (NK)］, and adverse drug reactions were compared between the two groups. 
Results The number of effective analgesic pump, the rate of relief analgesia and the dosage of sufentanil in the research group were (3.20±0.41) times, 10.17% and (55.27±6.85) μg, respectively, which were lower than those in the control group (P＜0.05). The VAS scores of the research group were (2.19±0.36), (1.43±0.29) and (0.72±0.15) at 2 h, 24 h and 48 h after surgery, respectively, which were lower than those in the control group (P＜0.05). HR and MAP of the research group were (80.10±6.18) times/min and (85.36±6.10) mmHg （1 mmHg=0.133 kPa） respectively immediately after intubation (T1) and at 1 h (T2) after initiation of surgery, which were lower than those in thecontrol group (P＜0.05). The Cor and ACTH of the research group at 24 h after surgery were (342.07±43.79) nmol/L and (16.29±3.74) ng/L, respectively, which were lower than those in the control group (P＜0.05). The CD3+, CD4+ and NK cells in the research group were (53.27±5.12) %, (29.42±3.07) % and (21.18±3.16) %, respectively, which were higher than those in the control group (P＜0.05). There was no difference in the total incidence of adverse drug reactions between the two groups (P＞0.05). 
Conclusion Epidural block using low-concentration ropivacaine combined with stellate ganglion block has a definite perioperative analgesic effect in patients receiving radical resection of ovarian cancer, which can alleviate stress response, improve postoperative short-term immunosuppression, reduce the use of analgesic drugs, maintain intraoperative hemodynamics, and do not increase the risk of adverse drug reactions. 

Key words: ovarian neoplasms, stellate ganglion block, ropivacaine, epidural block