Abstract: Objective To explore the influence of different doses rosuvastatin on peroxidation and proliferation of vascular smooth muscle cells for experimental atheriosclerosis rats.Methods Forty-six male rats were divided randomly into five groups,control group(n =6) was given with ordinary feed,high methionine group(n =10)with 2% methionine on this basis, folic acid group(n =10)with high methionine feed after four weeks,adding folic acid for lavage by 0.8 mg/kg per day,low dose group(n = 10)and high dose group(n = 10)with high methionine feed after four weeks,adding rosuvastatin for lavage by 1 mg/kg per day,2 mg/kg per day, respectively.The rats were executed after last lavage for four hours to get blood and carotid artery.Plasma homocysteine (Hcy),content of plasma malondialdehyde (MDA),activity of glutathione peroxidase (GSH-PX) and inflammatory factors were detected,and the relative thickness of carotid artery walls was measured.Results At 12 weeks after modeling,the level of plasma Hcy was significantly increased than before modeling,the order was high methionine group< folic acid

Key words: arteriosclerosis, rosuvastatin, muscle, smooth