Loading...

Table of Content

    25 December 2016, Volume 37 Issue 12
    Previous Issue    Next Issue
    Studies on the correlation between cystatin C level and chronic heart failure in diagnosing and shortterm prognosis
    ZU Xiuguang1, ZHANG Shaojuan1, WANG Hongchao1, WANG Lixin2
    2016, 37(12):  1365-1369.  doi:10.3969/j.issn.10073205.2016.12.001
    Asbtract ( 578 )   PDF (386KB) ( 313 )  
    Related Articles | Metrics
    Abstract ] Objective ToinvestigatetherelationshipbetweencystatinC ( CysC ) leveland
    chronicheartfailure ( CHF ) indiagnosingandshort-termprognosis.Methods Onehundredand
    thirty-eightpatientswithCHFwerechoosedastheCHFgroup , 50caseshealthypeoplewere
    choosedasthecontrolgroup.N-terminalpro-B-typenatriureticpeptide ( NT-proBNP ), CysC ,
    serumcreatinine ( SCr ), urea , uricacid ( UA ), leftventricularejectionfraction ( LVEF ) were
    measuredinthecontrolgroupandtheCHFgroupbeforeandaftertreatment.TheCHFgroup
    wasfollowedupfor6monthstorecordall-causemortality , rehospitalizationforCHFandmajor
    cardiovascularevents ( heartfailure , acutecoronary syndrome , arrhythmia associated with
    hemodynamicdisorder ) .Results ThelevelsofNT-proBNPandCysCoftheCHFgroupwere
    significantlyhigherthanthatofthecontrolgroup , andthevaluesweregraduallyincreasedwith
    theworseningofheartfunction.ThelevelofLVEFoftheCHFgroupwassignificantlylower
    thanthatofthecontrolgroup , andLVEFvaluewasgraduallyreducedwiththeworseningof
    heartfunction.NT-proBNP , CysCandUAbeforetreatmentweresignificantlyhigherthanthat aftertreatment , LVEF beforetreatmentwaslowerthanthataftertreatment.NT-proBNP ,
    CysC , ScrandUAoftheeventgroupwerehigherthanthatofthenongroup , LVEFoftheevent
    groupwassignificantlylowerthanthatofthenongroup.Logisticanalysisshowedthathighlevel
    ofCysC , highlevelofNT-proBNPandlowlevelofLVEF wereindependentriskfactorsfor
    recentcardiovascularadverseevents.Conclusion ThelevelofCysC , NT-proBNPandLVEFare
    closelyrelatedtoCHF , theycanreflecttheseverityofcardiacfunction.ThelevelofLVEF ,
    CysCandNT-proBNParecloselyrelatedtotheshort-termprogn
    Clinical effect of ticagrelor antithrombotic therapy on highrisk coronary patients with low response to Clopidogrel
    PENG Lingyun, DING Huaisheng, LI Yuan, XIAO Dayan, LIU Ankang, WANG Hui
    2016, 37(12):  1370-1373,1382.  doi:10.3969/j.issn.10073205.2016.12.002
    Asbtract ( 633 )   PDF (378KB) ( 244 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Toinvestigatetheeffectsofticagrelorinhigh-riskcoronarypatients
    whohavehighon-treatmentplateletreactivity ( HTPR ) withclopidogrelafterpercutaneous
    coronaryintervention ( PCI ) .Methods Atotalof209patientswithstableorunstableanginawho
    hadbeenreceivingclopidogreltreatmentwereselected.VerifyNow P2Y12assay wasusedto
    detecttheplateletreactivity.HTPRwasdefinedasP2Y12reactionunits ( PRU ) ≥208.Subjects
    wererandomizedintoHTPRgroup ( n =97 ) andnon-HTPRgroup ( n =112 ) .Totally , 63patients
    inHTPRgroupprecededPCI , individualsreceivedPCIwithHTPRwererandomlyassignedinto
    clopidogreltreatmentgroup ( n =30 ) andticagrelortreatmentgroup (
    n =33 ), receivingeither
    additionalclopidogrel300mgorticagrelor180mgbeforecoronaryangiography.Allthepatients
    continuedwithclopidogrelorticagrelortreatmentafterPCI.Clinicalcharacteristicand PCI
    relatedparametersforsubjectswhounderwentPCIwererecorded.TroponinandPRUlevelswere
    determinedbeforeandafterPCI , postoperativebleedingandmajoradversecardiovascularevents rateswereassessedafterPCI.Results Nosignificantdifferencesofclinicalcharacteristicsand
    PCIrelatedparameters werefound betweentheclopidogreltreatmentgroupandticagrelor
    treatmentgroup ( P >0.05 ) .NodifferencewasobservedoftroponinandPRUlevels24hbefore
    PCI ( P >0.05 ) .TicagrelortreatmentremarkablyreducedthePRUandtroponinlevelsafterPCI
    incomparisonwithclopidogreltreatmentgroup ( P <0.05 ) .Therateofpostoperativebleeding
    wassimilarbetweenthetwogroups.However , theincidenceofmajoradversecardiovascular
    events1yearafterPCIwassignificantlylowerintheticagrelorgroupcomparedtotheclopidogrel
    group ( P <0.05 ) .Conclusion Modifyingantiplatelettreatmenttoticagrelorinhigh-riskcoronary
    patientswithHTPRtoclopidogrelsignificantlyinhibitsplateletactivity , decreasestroponinlevel
    andreducestheincidenceofadversecardiovasculareventsafter1yearsofPCI.
    Effects of Artesunate on DNMT1 expression in highrisk MDS cell strain of SKM-1
    WANG Ying， NIU Zhiyun， XING Lina， QIAO Shukai， PAN Ling*
    2016, 37(12):  1374-1378.  doi:10.3969/j.issn.10073205.2016.12.003
    Asbtract ( 665 )   PDF (1KB) ( 113 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Toobservetheeffectsofartesunate ( ART ) ongeneexpressionlevels
    ofDNMT1byusingSKM-1cellsastheresearchobject , andprovidelaboratoryevidenceinvitro
    fortheusageofARTinMDStreatment.Methods AfterbeingtreatedwithART ( 1 , 5and10
    μ mol
    / L ), DNMT1mRNAchangesinSKM-1cellswereobservedwithRT-PCR , andtheprotein
    expressionchangeswereobservedwith WestBlot.Then , theexpressionchangesofp15INK4b ,
    theDNMT1targetinggenewereobservedbyusingreal-timequantitativeRT-PCR , andthe
    changesofp15INK4bpromoter methylationstate wereobservedbyusing methylationPCR.
    Results AfterbeingtreatedwithART ( 1 , 5and10 μ mol
    / L ), thedifferencewasstatistically
    significantforDNMT1geneexpressioninSKM-1cellscomparedwithcontrolgroup ( P <0.05 ),
    buttherewasnosignificantdifferenceinthethreedosegroups ( 1 , 5and10 μ mol
    / L )(
    P >0.05 )  AstoDNMT1proteinexpression , comparedwith5 μ mol
    / Lgroup , therewassignificantlylower
    intheothertwogroups ( 1and10 μ mol
    / L )(
    P <0.05 ), andalsosignificantlylowerthanthatin
    controlgroup ( P <0.05 ) .Howevertherewasnosignificantdifferenceamongtheothergroups
    (
    P >0.05 ) .AfterSKM-1cellsbeingtreatedwithARTfor3h , 6hand12h , comparedwith
    controlgroup , thedifferenceofDNMT1geneandproteinexpressionsinthethreegroups (
    3h , 6
    hand12h ) wassignificant ( P <0.05 ) .Besides , thedifferenceofgeneexpressionbetweenthe
    twogroups ( 3h , 6h ) andthe12hgroupwasalsosignificant ( P <0.05 ) .Buttherewasno
    significantdifferentofproteinexpressioninothertreatedgroups ( P >0.05 ) .AfterSKM-1cells
    beingtreatedwithART , p15INK4BmRNAlevelofSKM-1cellsinthethreegroups ( 5and10
    μ mol
    / Lgroups , anddecitabinegroup ) wasstatisticallyhigherthanthatincontrolgroup (
    P <
    0.05 ), withthelevelin10 μ mol
    / Lgroupthehighestinthefivegroups , andthesignificant
    differencewasonlyfoundbetween10 μ mol
    / Lgroupandthefourgroups (
    controlgroup , 1 μ mol
    group , 5 μ molgroupand decitabinegroup )( P <0.05 ) .Afterbeingtreated with ART ,
    p15INK4bpromotermethylationlevelwasdecreasedinSKM-1cells , butthedifferencewasnot
    significant ( P >0.05 ) .Onthecontrary , thelevelofpromoterunmethylationstateinARTgroup
    wasincreasedcomparedwithtwoothergroups ( controlgroupandthedecitabinegroup )( P <
    0.05 ) .Conclusion ART can restorethe expression of p15INK4b byinhibit
    Effect of changes in dietary fat content on the ghrelin levels in diabetic rats
    CHEN Yunxia, GAO qian*, LIU Chunyan, ZHAO Shuling
    2016, 37(12):  1379-1382.  doi:10.3969/j.issn.10073205.2016.12.004
    Asbtract ( 461 )   PDF (380KB) ( 128 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Tostudytheregulationofdietaryfatindiabeticratsontheweight ,
    differentpartsofthefatandghrelin.Methods SixtymaleSDratsweredividedintotwogroups
    randomly : 15normalcontrolratsand45testrats.Thetestratswerefedwithhighfatdietfor
    eightweeksandasingleintraperitonealinjectionofstreptozotocin ( STZ , 30mg /
    kg
    ) toestablish
    ananimalmodelofdiabetes.36diabeticratmodelwassuccessfullyestablished.Thediabeticrats
    wererandomlydividedintofollowinggroups : 18generaldietdiabeticratsand18high-fatdiet
    diabeticrats.Thenormalcontrolratsandgeneraldietdiabeticratswerefedwithgeneraldiet.The
    high-fatdietdiabeticratswerefedwithhigh-fatdiet.Aftersixweeks , allratswerekilled.Blood
    andadiposetissuesampleswerecollectedinallrats.Serum ghrelinwasdetectedbyenzyme-
    linkedimmunoassay.Results Thegeneraldietdiabeticratsandhigh-fatdietdiabeticratswere
    significantlyhigherin weight , epididymalfat , epinephrinefatand mesentericfatthannormal
    controlrats , andweresignificantlylowerinplasmaghrelinconcentrationthannormalcontrol
    rats.Conclusion Changesindietaryfatcontentplayaregulatoryroleonlevelsofghrelinin
    plasmathataffectweightandenergyintake.
    Study on the efficacy of flupenthixol melitracen combined with Weichang'an Pill in the treatment of patients with diarrheapredominant irritable bowel syndrome
    GAO Guangzhou, YAO Hongmei， ZHANG Xiaoming, YANG Yang, ZHANG Jinzhuo， HAO Yingxia*
    2016, 37(12):  1383-1386,1390.  doi:10.3969/j.issn.10073205.2016.12.005
    Asbtract ( 647 )   PDF (417KB) ( 253 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Toobservetheclinicalefficacyofflupenthixolmelitracencombined
    with Weichang'aninthetreatmentdiarrhea-predominantirritablebowelsyndrome ( IBS-D ) .
    Methods Atotalof77IBS-Dpatientswasdividedrandomlyintocontrolgroupandexperimented
    group.Thepatientsofcontrolgroupweretreatedwith Weichang'anPill0.8gthreetimesper
    day.Onthebasisofthetreatmentofcontrolgroup , thepatientsofexperimentalgroupwere
    givenflupenthixolmelitracen10.5 mgafterbreakfastandlunchperday.Thepatientswere
    evaluatedbythe Hamilton AnxietyScale ( HAMA ), Hamilton Depression Scale ( HAMD ),
    abdominalpainanddiarrheasymptomscoreswhenenrolledandwerefollowedupatthefourth
    week.Theadverseeffects wereobservedandrecorded.Results Beforethetreatment , the
    subjectsinthe2groupswerematchableintheirdepressionandanxietyratios , andtherewereno
    statisticaldifferencebetweenthetwogroupsinHAMA , HAMDandabdominalpainanddiarrhea symptomscores ( all P >0.05 ) .Afterfourweekoftreatment , theefficacyrateofabdominalpain ,
    diarrheaandtotaleffectiveratesoftreatmentgroupwerehigherthanthoseofcontrolgroup.The
    differenceswerestatisticallysignificant ( P <0.05 ) .Thescoresof HAMA and HAMD of
    experimentalgroupweresignificantlylowerthanthoseofcontrolgroup ( P <0.05 ) .Conclusion
    Flupenthixol melitracen combined with Chinese medicine Weichang'an Pill demonstrates
    significantefficacyintheimprovementofdepression , anxietyandmainsympto
    Clinical observation of insulin determir combined with metformin in type 2 diabetes patients
    YANG Liu, TIAN Li, MENG Xianjie, LIU Hongmei, ZHANG Lihua, YE Chunfang
    2016, 37(12):  1387-1390.  doi:10.3969/j.issn.10073205.2016.12.006
    Asbtract ( 676 )   PDF (375KB) ( 180 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Toobservetheefficacyandsafetyofinitiatinginsulintherapywith
    insulindetemirinoralantidiabeticdrugmetformin-treatedpatientswithtype2diabetesmellitus
    ( T2DM ) whosebloodglucoseisnotyetuptothestandard.Methods SixtysubjectswithT2DM
    wererandomlydividedintotwogroups , insulindetermircombiningwith metformin ( treatment
    group ) and glimepriridecombining with metformin ( conrtolgroup ) .Thistreatmentruly
    monitoredhemoglobinA 1 c , 7-pointbloodglucose , bodyweight , hypoglycemicevent , allergic
    reaction.Duringthe32-week-treatment , thedosagesofmedicinewereadjustedaccordingtoself-
    recordeddaily7-pointbloodglucose.Thisclinicalobservationistoevaluatetheefficacyandsafety
    ofinsulindetermir.Results The7-pointbloodglucoseofthe2groupsaftertreatmentwere
    significantlylowerthanthosebeforetreatmen ( P <0.05 ) .Thetreatmentgroupwaslowerthan
    thecontrolgroup ( P <0.05 ), butthere'snosignificantdifference (
    P >0.05 ) .Therewasno
    hypoglycemiceventorallergicreaction duringthetreatment.Conclusion Insulin detemir
    combinedwith metformincertainlyreducebloodglucoseinT2DM patientseffectively.Insulin
    detemircombinedwithmetformindoesnotincreasethepatient'sbodymass , nordoesitincrease
    theincidenceofhypoglycemiceventsandallergicreactions
    The correlation between radiotherapy sensitization of βelemene and tumor angiogenesis
    HUANG Jiafu
    2016, 37(12):  1391-1393.  doi:10.3969/j.issn.10073205.2016.12.007
    Asbtract ( 441 )   PDF (312KB) ( 130 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Toexplorethecorrelationbetweenradiotherapysensitizationof β -
    elemeneandtumorangiogenesis.Methods Whentransplantedtumorshadaccumulatedfor0. 8-
    1. 0cm
    3 ,
    tumor-burdenednudemiceweredividedinto8groupsrandomly ( eachgroupforfive ),
    whichincludes : blankgroup , 25mg / kgdrugsgroup , 45mg / kgdrugsgroup , 100mg / kgdrugs
    group , theradiotherapygroup ( NaCl+radiotherapy ), 25mg
    / kgdrugs+radiotherapygroup , 45
    mg
    / kgdrugs+radiotherapygroup , 100mg / kgdrug+radiotherapygroup.
    β
    -elemenewasinjected
    accordingtodose , and NaClwasinjectedtoblankgroup.Volumedoublingtime ( VDT ) and
    enhancementfactor werecompared between groups.Theexpression ofvascularendothelial
    growthfactor ( VEGF ) andCD34werecomparedbetweengroups.Results VDTofB1 , C1and
    D1groupwerehigherthantheA1 , andVDTofD1groupwashigherthanB1 , C1group , which
    thedifferenceswerestatisticalsignificance ( P <0.05 ) .VDTofB2 , C2andD2groupwerehigher
    thanA2group , andD2andC2groupwerehigherthanB2 ,
    atthesametimeD2groupwashigher
    thanC2group , whichthedifferenceshadstatisticalsignificance
    ( P <0.05 ) .Thedifference
    betweenradiotherapygroupandno-radiotherapygroupwasnostatisticallysignificant ( P <0.05 ) .
    Thedoseof45 mg
    / kgand100 mg / kghadsensitizationeffect.Averageopticaldensityand
    Construction and evaluation of multidisciplinary nursing team in elderly patients with hip fracture
    DONG Yunfang1, LI Yujia2, YAN Xiaoli2, CHEN Caizhen2, LI Dongzheng3, ZHANG Xiuguo4*
    2016, 37(12):  1394-1398,1406.  doi:10.3969/j.issn.10073205.2016.12.008
    Asbtract ( 517 )   PDF (446KB) ( 221 )  
    Related Articles | Metrics
    [ Abstract ] Objective To explore the establishment , management and effect of
    multidisciplinarycareteamintheelderlypatientswithhipfractureinthemultidisciplinemedical
    cooperationmode.Methods Amultidisciplinarynursingteamincludedepartmentoforthopedics ,
    respiration , cardiology , endocrinologywassetup.Divisionofresponsibilities , workflow , nurse
    schedulingand quality according to the multidisciplinary medicalcooperation mode were
    managed.Thepatient'ssatisfaction , caredefectsandtheoreticalknowledgeandtechnicallevel
    were evaluated and compared between before and after organization of multidisciplinary
    cooperationteam.Results Comparing withbeforeorganizationof multidisciplinarynursing
    team , thepatient'ssatisfaction ( P <0.05 ), thescoresoftheoreticalknowledge ( P <0.05 ),
    technicalqualifiedrate ( P <0.05 ) weresignificantlyimprovedandthecaredefectswasreduced
    (
    P <0.05 ) .Conclusion Multidisciplinarycareteamisanewnursingmodetoadapttothemulti
    disciplinehealthcarecooperationmodeandanewtypeofnursingcareforelderlypatientswith hipfracture.
    Application of quality control circles activities in the improvement of health education satisfaction of the neurology patients in hospital#br#
    PANG Ke, LIU Xin, LI Yi, DENG Yongmei*
    2016, 37(12):  1399-1401,1411.  doi:10.3969/j.issn.10073205.2016.12.009
    Asbtract ( 471 )   PDF (390KB) ( 167 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Toimprovethehealtheducationsatisfactionoftheneurologypatients
    inhospital.Methods Thequalitycontrolcircles ( QCC ) groupwasestablish , and100patientsin
    hospitalrandomly wereselected , whom wereseperatedintocontrolgroupandexperimental
    group.Weconfirmedthethemeofthesurvey , followedbytheprocessofthePDCAcirculation ,
    analyzedtheimpactfactorsofthesatisfaction ofhealth education , tookreciprocalaction.
    Differenceofsatisfactionforbothgroups wascompared , andtheimprovementofpatients'
    satisfactionbyQCCwasobserved.Results Fiftysurveyquestionnairesweredistributedtoboth
    groups , 100% werecollected , thesatisfactionofcontrolgroupwashigherthantheexperimental
    group , whichissignificantdifferent ( P <0. 05 ) .ThetargetyieldrateoftheQCCwas118%and
    progressratewas21% , whichshowedgreateffectivenessoftheQCC.Conclusion TheQCCcan
    improvethehealtheducationsatisfactionoftheneurologypatientsinhospitaleffectively , can
    strengthentheenthusiasm , confidenceandteamcohension , canimprovetherelationshipbetween
    nursesandpatientsandthemanagementawarenessofthenurses.
    Effects of specific CTL which are activated by DC modified with IL27 gene and esophageal tumor lysate on esophageal carcinoma cell mitochondria membrane potential and cell apoptosis
    WANG Shaoqing1, ZHANG Wanyu2, WANG Dapeng3, WANG Shidong4, MI Yuan5, WANG Lei5*
    2016, 37(12):  1402-1406.  doi:10.3969/j.issn.10073205.2016.12.010
    Asbtract ( 431 )   PDF (773KB) ( 163 )  
    Related Articles | Metrics
    [ Abstract ] Objective Toexploretheeffectofspecificcytotoxiclymphocyte (
    CTL ) whichare
    activatedbydendriticcell ( DC ) modified withIL-27 geneandesophagealtumorlysateon
    esophagealcarcinomacellapoptosis.Methods After makingthe nude mice models with
    esophagealcancercellsuccessfully , the mice wereimmunized withspecific CTL whichare
    activatedbyIL-27genemodifiedDCloadedwithesophagealtumorlysate ( DC IL-27+Ag ) .Thecell apoptosisratewasanalyzedbyAnnexinV / PIstaining.Themitochondrialmembranepotential
    was measuredby Rhodamine123stainingandtheexpressionlevelofcaspase-3protein was
    detectedbyflowcytometry.Results Theratioofapoptosis , membranepotentialofmitochondria
    andexpressionofcaspase-3of5groupsshowedsignificantdifference ( P <0.05 ) .Theratioof
    apoptosisandcaspase-3proteinexpressioninDC IL-27+Ag group , DC IL-27 groupandDC naive group
    werehigherthanthoseinPBSgroup ( controlgroup ) .Themembranepotentialofmitochondriain
    DC IL-27+Ag group , DC IL-27 groupandDC naive groupwashigherthanthatinPBSgroup.Theratioof
    apoptosisandcaspase-3proteinexpressioninDC IL-27+Ag , group , DC IL-27 groupand , DC naive group
    werehigherthanthoseinTnaivegroup , butthemembranepotentialofmitochondriainDC IL-27+Ag
    group , DC IL-27 groupandDC naive groupwaslowerthanthatinTnaivegroup.Theratioofapoptosis
    andcaspase-3proteinexpressioninDC IL-27+Ag group , DC IL-27 group werehigherthanthosein
    DC naive group , butthemembranepotentialofmitochondriainDC IL-27+Ag group , DC IL-27 groupwas
    lowerthanthatin DC naive group.Theratioofapoptosisandcaspase-3proteinexpressionin
    DC IL-27+Ag group , were higherthanthosein DC IL-27 group , butthe membrane potentialof
    mitochondriainDC IL-27+Ag groupwaslowerthanthatinDC IL-27 group.Conclusion SpecificCTL ,
    activatedbyDCmodifiedwithIL-27geneandesophagealtumorlysate , efficientlyplaycytotoxic
    effectontumor-bearing miceinvivothroughreducingthemitochondrialmembranepotential ,
    initiatingth
    Clinnical efficacy of bronchial arterial infusion chemotherapy and embolization in the treatment of stage Ⅲ nonsmall cell lung cancer
    WANG Jiyun1， LI Ting2， YU Ke1， LI Wangang1*， TIAN Haoyin1， PEI Xiaodong1
    2016, 37(12):  1407-1411.  doi:10.3969/j.issn.10073205.2016.12.011
    Asbtract ( 511 )   PDF (1241KB) ( 123 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Toevaluatethecurativeeffectofthebronchialarterialinfusion
    chemotherapyandembolizationinstageⅢ non-smallcelllungcancer.Methods Onehundred
    andtwentycasesofstageⅢ non-smallcelllungcancerwererandomlydividedintoobservation
    groupandcontrolgroup.Theobservationgroupwasgiven4cyclesbronchialarterialinfusion
    chemotherapyandembolizationofiodizedoil , thenthebronchialarterywasembolismedwith
    gelfoamcompletelyattheendofthefourthcycle.Thecontrolgroupwasgivenroutinebronchial
    arterialinfusionchemotherapy.Thenitwascomparedoftwogroupsthatthecurativeeffect , side
    effects , andassesstheclinicalvalueofbronchialarteryperfusionchemotherapyembolism.
    Results Thecompleteremission ( CR ) andpartialremission ( PR ) intheobservationgroupand
    controlgroupwere41cases ( 68. 3% ) and32cases ( 53. 3% ) respectively.Progressionfreesurvialof patientsintheobvervationgroupwere ( 9. 8±1. 6 ) monthsand ( 5. 1±0. 8 ) months , themedian
    survivalwere ( 17. 5±2. 2 ) monthsand ( 11. 8±1. 5 ) monthsrespectively , threeindicatorshave
    statisticalsignificance ( P <0.05 ) .Observationgroup1 , 2 , 3 , 5yearssurvivalrate ( % ) 70. 7 ,
    47. 4 , 13. 6 , 8. 8 , andcontrolgroupin59. 7 , 32. 4 , 14. 6 , 9. 5 ; Therewassignificantdifferencefor
    1 , 2yearsurvivalrate ( P <0.05 ), andnostatisticalsignificancefor3 , 5yearsurvivalrate ( P >
    0.05 ); Totaladversereactionratewas35. 6% , 35. 6% , withnostatisticalsignificance P >0.05.
    Conclusion BronchialarterialinfusionchemotherapyandembolizationforstageⅢnon-smallcell
    lungcancerinthenearfuturecurativeeffectissuperiortopurebronchialarterialinfusion , and
    withoutincreaseofsideeffects.Thismethodisworthyofclinicalpromotion.
    Clinical effect of different dose of ω3 polyunsaturated fatty acids in postoperative patients with esophagus cancer
    GONG Shunsong，MING Wei
    2016, 37(12):  1412-1415,1457.  doi:10.3969/j.issn.10073205.2016.12.012
    Asbtract ( 611 )   PDF (392KB) ( 131 )  
    Related Articles | Metrics
    [ Abstract ] Objective Toinvestigatetheeffectofdifferentdosesofω-3polyunsaturatedfatty
    acidoninflammatoryfactors , nutritionalstatusandpostoperativecomplicationsinpatientswith
    esophagealcarcinoma.Methods Ninety-twopatients wtihesophaguscancer wererandomly
    dividedintoacontrolgroup ( 32cases ), experimentalgroup1 ( 30cases ) andtheexperimental
    group2 ( 30cases ) .Allpatientsweregiven6daysofparenteralnutritionsupporttreatment
    , and
    thenweregivenliquiddietafterrecoveryofgastrointestinalfunction.Controlgroupwasgiven
    saline100 mL / d , the experimentalgroup 1 weretreated with saline 50 mL / d and ω-3
    polyunsaturatedfatty acid 50 mL / d , the experimental group 2 were treated with ω-3
    polyunsaturatedfattyacid100 mL / d , allthetreatmentcourse wasone week.Procalicitonin
    (
    PCT ), C-reactiveprotein ( CRP ) andinterleukin-6 ( IL-6 ), albumin ( Alb ), lymphocyte ( LYM ),
    prealbumin ( PA ) andtransferrin ( TFN ) ofpatientswerecollectedandcomparedonpreoperative day1 , postoperativeday1 , andpostoperativeday7.Thedrugreactionsandtheoccurrenceof
    postoperativecomplicationswererecorded.Results Onpostoperativeday7 , thePCT , CPRand
    IL-6ofexperimentalgroup1andexperimentalgroup2werelowerthanthatofconrolgroup
    ( P <0.05 ), the PCT , CPR andIL-6 ofexperimentalgroup2 werelowerthan that of
    experimentalgroup1 ( P <0.05 ), theLYM ofexperimentalgroup1andexperimentalgroup2
    werehigherthanthatofconrolgroup ( P <0.05 ), theLYMofexperimentalgroup2werehigher
    thanthatofexperimentalgroup1 ( P <0.05 ) .Therewere3casesofwoundinfection , 2casesof
    pulmonaryinfection , 1casesofanastomoticleakageincontrolgroup , 3casesofwoundinfection
    inexperimentalgroup1 , 3casesofpulmonaryinfectionand1casesofincisioninfectionin
    experimentalgroup2.Theincidenceofcomplicationswas3. 33% ( 1 / 30 ) inexperimentalgroup2 ,
    whichwaslowerthanthatincontrolgroup21. 88% ( 7 / 32 ) andtheexperimentalgroup2 ( P <
    0.05 ) .Theincidenceofcomplicationswerenotstatisticallysignificant ( P >0.05 ) .Conclusion ω-
    3polyunsaturatedfattyacidscanreducetheinflammatoryreactioninpatientswithesophageal
    cancer , andimprovethenutritionalstatusofpatientsaftersurgery.Theapplicationoflargedose
    ismoreobvious , andcanreducetheincidenceofpostoperativecomplications.
    Effect of SuperPath minimally invasive incision total hip arthroplasty on femoral head necrosis and the quality of life
    REN Dongwei, YANG Gejun*, ZHAO Hualei, ZHA Jianyue, LU Shun, XU Yongsheng
    2016, 37(12):  1416-1419.  doi:10.3969/j.issn.10073205.2016.12.013
    Asbtract ( 558 )   PDF (370KB) ( 212 )  
    Related Articles | Metrics
    [
    Abstract ] Objective ToexplorethetherapeuticeffectofSuperPathincision minimally
    invasivetotalhiparthroplastyforfemoralheadnecrosispatientsandtheirqualityoflife.Methods
    Fourty-twopatientswithfemoralheadnecrosiswererandomlydividedintocontrolgroupand
    experimental group.Control group patients were received total hip arthroplasty , and
    experimentalgroupwerereceivedSuperPathincisionminimallyinvasivetotalhiparthroplasty.To
    evaluatethetherapeuticeffect , weanalyzetheHarrisscoreofpatientsbeforeand1months , 2
    monthsand3monthsaftersurgeryandcomparetwolegslengthdifference , andWOMACscore
    ofpatientsbeforeandaftertreatmenttoevaluatethequalityoflife.Results Afterthesurgery ,
    patients'Harrisscoresweresignificantlyimproved ( P <0.05 ); whileWOMACscoresofpatients
    weresignificantlylowerthan those beforetreatment ( P < 0.05 ) .There were significant
    differencesbetweenthetwo groupsatdifferenttimes.Howeverthere was no significant
    differencebetweenthegroups ( P >0.05 ) .Thetwolegslengthdifference , thelengthofstayand
    thedurationbetweentheoperationandthefirsttimeoutofbedofpatientsintheexperimental groupweresignificantlyshorterthanthoseinthecontrolgroup ( P <0.05 ) .Conclusion Treating
    femoralheadnecrosis with SuperPathincision minimallyinvasivetotalhiparthroplastycan
    effectivelyreducesurgicaltrauma , andimprovethequalityoflifeofpatients.Itisworthyof
    promotion.
    Vertebral fixation combined with fenestration in the treatment of thoracolumbar vertebral fractures with spinal canal invasion
    LI Dongfeng, LIU Fajing, HU Chengdong, HUO Xiwei, LI Yanfei
    2016, 37(12):  1420-1423,1427.  doi:10.3969/j.issn.10073205.2016.12.014
    Asbtract ( 465 )  
    Related Articles | Metrics
    [
    Abstract ] Objective ToexplorethetherapeuticeffectofSuperPathincision minimally
    invasivetotalhiparthroplastyforfemoralheadnecrosispatientsandtheirqualityoflife.Methods
    Fourty-twopatientswithfemoralheadnecrosiswererandomlydividedintocontrolgroupand
    experimental group.Control group patients were received total hip arthroplasty , and
    experimentalgroupwerereceivedSuperPathincisionminimallyinvasivetotalhiparthroplasty.To
    evaluatethetherapeuticeffect , weanalyzetheHarrisscoreofpatientsbeforeand1months , 2
    monthsand3monthsaftersurgeryandcomparetwolegslengthdifference , andWOMACscore
    ofpatientsbeforeandaftertreatmenttoevaluatethequalityoflife.Results Afterthesurgery ,
    patients'Harrisscoresweresignificantlyimproved ( P <0.05 ); whileWOMACscoresofpatients
    weresignificantlylowerthan those beforetreatment ( P < 0.05 ) .There were significant
    differencesbetweenthetwo groupsatdifferenttimes.Howeverthere was no significant
    differencebetweenthegroups ( P >0.05 ) .Thetwolegslengthdifference , thelengthofstayand
    thedurationbetweentheoperationandthefirsttimeoutofbedofpatientsintheexperimental groupweresignificantlyshorterthanthoseinthecontrolgroup ( P <0.05 ) .Conclusion Treating
    femoralheadnecrosis with SuperPathincision minimallyinvasivetotalhiparthroplastycan
    effectivelyreducesurgicaltrauma , andimprovethequalityoflifeofpatients.Itisworthyof
    promotion.
    Effect and clinical efficacy of lienal polypeptide injection on immune function of cervical cancer patients with neoadjuvant chemotherapy
    HAN Hua1， WEI Qiang2， QIU Gang3， LI Jie1， YAN Ping1
    2016, 37(12):  1424-1427.  doi:10.3969/j.issn.10073205.2016.12.015
    Asbtract ( 543 )   PDF (379KB) ( 163 )  
    Related Articles | Metrics
    [ Abstract ]
    Objective Toobservetheeffectandclinicalefficacyoflienalpolypeptideinjection
    onimmunefunctionofcervicalcancerpatients with neoadjuvantchemotherapy.Methods
    Randomlyselected52casesofcervicalcancerpatients withneoadjuvantchemotherapy were
    dividedintocontrolgroupandstudygroup.Patientsinthecontrolgroup weretreated with
    paclitaxelplusnedaplatinchemotherapy , whilethepatientsinthestudygroupweretreatedwith
    chemotherapyandLienalPolypeptideInjection.Theshort-term efficacy , adversereactionand
    immunefunction werecomparedbetweenthe2groups.Results Theresponserateofstudy
    groupandcontrolgroupwas65. 4% and61. 5%respectively , withoutsignificantdifference ( P >
    0.05 ) .Thearrestofgastrointestinalreaction , bonemarrow , neurotoxicityandimpairmentof
    liverfunctionofthestudygroupweresignificantlylowerthanthatinthecontrolgroup , andthe
    differencewasstatisticallysignificant ( P <0.05 ) .ThemeanvaluesofCD3
    + ,
    CD4
    + ,
    CD8
    +
    and
    NK cellsinthestudy group wereimprovedto certain differentdegrees , with statistical
    significancecompared withthecontrolgroup ( P <0.05 ) .Conclusion Thelienalpolypeptide
    injectioncanimprovetheimmunefunction , reducethesideeffectsofchemotherapy , andhasthe effectofreducingtoxicityandincreasingtheefficiency.
    The clinical research of biomimetic electrical technique in prevention of  lower limb deep venous thrombosis in eldly patients after gynaecological laparoscope
    ZHANG Bin， GUO Lina， LI Wenjing
    2016, 37(12):  1428-1431,1436.  doi:10.3969/j.issn.10073205.2016.12.016
    Asbtract ( 419 )   PDF (422KB) ( 170 )  
    Related Articles | Metrics
    [ Abstract ] Objective Toassessthevalueofbiomimeticelectricaltechniqueintheprevention
    oflowerdeepvenousthrombosisineldlypatienaftergynaecologicallaparoscope , andthereby
    exploreasafeandeffectiveprophylaxismethod.Methods Thisstudyincluded120eldlypatients
    over60yearsofageaftergynaecologicallaparoscope.Thepatientsweredividedrandomlyinto
    groupA ( routinenursinggroup ), groupB (
    elasticsockgroup ) andgroupC ( biomimeticelectrical
    techniquegroup ) .Thebloodflow velocityandchangesinhemodynamicsofthepatientwere
    determinedandcomparedamongthe3groups.Results Prothrombintime ( PT ), activatedpartial
    thromboplastintime ( APTT ) ofgroupCarehigherthanthatofgroupAandBin3daysafter
    operation , D-dimerislowerthangroupAandB.PT , D-dimerofgroupBishigherthanthatof
    groupA ( P <0.05 ) .APTTofgroupBwasnostatisticallysignificantdifferencecomparedwith
    groupC ( P >0.05 ) .Plasmaviscosity , erythrocytedepositedandplateletadhesionrateofgroupC
    islowerthanthatofgroup AandgroupB.Bloodplasmaviscosity , Bloodplasmaviscosity ,
    erythrocytedepositedandplateletadhesionrateofgroupBarelowerthanthatofgroupA ( P <
    0.05 ) .SharesalwaysvenousbloodflowvelocityofgroupCisgreaterthanthatofgroupAand groupB , groupBgreaterthanthatofgroupA (
    P <0.05 ) .Stocktotalveindiameterofthree
    groupsvaluedifferenceshavenostatisticalsignificance ( P >0.05 ) .Conclusion Biomimetic
    electricaltechniqueineldlypatientsaftergynaecologicallaparoscopecanacceleratethebloodflow
    velocityinthelowerlimbdeepveinsandimprovebloodheightglutinousconditiontoeffectively
    preventdeepvenousthrombosis.
    The application value of fetal umbilical artery and middle cerebral artery resistance index in predicting fetal hypoxia
    CHEN Jianghong1, WANG Na1, HUANG Nailei1, GAO Yong2*
    2016, 37(12):  1432-1436.  doi:10.3969/j.issn.10073205.2016.12.017
    Asbtract ( 494 )   PDF (419KB) ( 105 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Todiscusstheapplicationvalueoffetalumbilicalarteryandmiddle
    cerebralarteryresistanceindexinpredictingfetalhypoxia.Methods Atotalof120pregnant
    womeninhospitalwasselectedanddividedintocontrolgroupandobservationgroup , thecontrol
    groupwith62casesofnormalpregnancy , theobservationgroupwith58casesoffetalhypoxia
    pregnancy , theuseofcolorDopplerultrasounddetectionoffetalumbilicalartery , middlecerebral
    artery , pulsatilityindex (
    PI ), resistanceindex ( RI ) andpeaksystolicandenddiastolicvelocity
    ratio ( S / D ), and calculatetheircorrespongdingratio , andthetwo groups ofdata were
    statisticallyanalyzed.Results Theumbilicalarteryresistanceindexintheobservationgroupwas
    significantlyhigherthanthatinthecontrolgroup ( P <0.01 ) .The middlecerebralartery
    resistanceindex wassignificantlylowerthanthatincontrolgroup ( P <0.01 ) .Theratioof
    PI umbilicalartery / middlecerebralartery , RI umbilicalartery / middlecerebralartery andS / D umbilicalartery / middlecerebralartery offetalumbilical 0.01 ), andhadagooddiagnosiseffectonthesensitivity , specificityand Youdenindexby
    PI umbilicalartery / middlecerebralartery >1. 00 , RI umbilicalartery / middlecerebralartery >1. 00andS / D umbilicalartery / middlecerebralartery >
    0. 72.Conclusion Resistanceindexesandtheircorrespondingratiooffetalumbilicalarteryand
    middlecerebralarteryinpredictingfetalhypoxiahasimportantvalue , which wascapableof
    predictingfetalhypoxiaandotheradversepregnancyphenomenons , andcandetecttheearly
    abnormalitiestoreduceneonatalmortalityrate , guidetheclinicalintervention , improvethe
    qualityofnewbornbirth.
    Clinical observation on ultrasoundguided with equal small does ropivacaine of different concentrations in brachial plexus block
    DING Qingmin, ZHANG Haiqing
    2016, 37(12):  1437-1440.  doi:10.3969/j.issn.10073205.2016.12.018
    Asbtract ( 504 )   PDF (352KB) ( 154 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Toobservetheefficacyandsafetyofultrasound-guidedwithequal
    smalldoesropivacaineofdifferentconcentrationsinbrachialplexusblock.Methods Sixty-three
    casesofupperlimbsurgerywithASA Ⅰ-Ⅱ electiveinbrachialplexusblockwereselected.
    Accordingtothedifferentanestheticconcentration , thepatientsweredividedinto A , B , C
    groups , 20patientsingroupA , 22casesingroupB ,
    21casesingroupC.GroupA wasgiven
    0. 375%ropivacaine26. 67 mL , groupB wasgiven0. 50% ropivacaine20. 00 mL , groupC was
    given0. 75%ropivacaine13.
    33mL.Theonsettimeofsensoryblock , thedurationofanalgesia ,
    thetotalnumberofblocksegmentandtotalblock , theonsetofmotorblock , therecoverytime
    andtheincidenceofcomplicationsin3groupswereobservedandrecorded.Results Threegroups
    ofpatientsweresatisfiedwiththeeffectofanesthesia.Sensoryblockadetimeandanalgesiceffect
    timeofgroupA werelongerthanBandCgroup , thetotalnumberofblocksectionwasmore
    thangroupB , C , thedifferenceswerestatisticallysignificant ( P <0.05 ) .Completeblockrateof
    threegroupswerenotstatisticallysignificant ( P >0.05 ) .ModifiedBromagescoreof3groupwere abovetwopoints.Threegroupswithin15 min movementcompletelyblockwereabove95%.
    GroupAmotionblockworktimewassignificantlylongerthanBandCgroup ( P <0.05 ) .GroupC
    campaignblockrecoverytimeis muchshorterthangroup A andB ( P <0.05 ) .Noserious
    complicationsoccurredin3group.IngroupA , 3patientshadchestdistress , andtheheartrate
    wastooslow.Conclusion Ultrasound-guidedbrachialplexusblockwithsmalldoesropivacaine
    canobtainsatisfactoryblockeffect.Withtheincreaseofconcentration , theonsettimeisshorter.
    Withtheincreaseofcapacity , theblockisbroader , andthedurationoftheblockislonger
    , but
    theincidenceofadversereactionsarealsolikelytoincrease.0. 375%-0. 50% ropivacaine ( 100
    mg
    ) ismoresuitablefortheultrasound-guidedbrachialplexusblock
    Studies on human pharmacokinetics and bioequivalence of entecavir dispersible tablet
    MA Jie, DONG Zhanjun*, BAI Wanjun, SONG Haojing, WU Yin, ZHI Xuran
    2016, 37(12):  1441-1444.  doi:10.3969/j.issn.10073205.2016.12.019
    Asbtract ( 846 )   PDF (492KB) ( 261 )  
    Related Articles | Metrics
    [
    Abstract ] Objective Toevaluatethebioequivalenceof2kindsofentecavirpreparationsin
    humanbodies.Methods Therandomized , crossed-overstudy wasconductedin20 healthy
    volunteers.AfterAsingleoraldoseofentecavirhydrochloridetestandreferencepreparations
    (
    containing0. 5mgentecavir ), thedruglevelsinplasmaweredeterminedbyhighperformance
    liquid chromatography-tandem mass spectrometry.The pharmacokinetic parameters were
    calculatedwithDAS3. 2. 7software , thenbioequivalenceofthetwopreparationswasevaluated.
    Results ThepeakconcentrationsC max , t max , t 1 / 2 and AUC 0-72h ofthe2formulations were
    (
    4. 41±1. 02 ) μ g / Land ( 4. 36±0. 89 ) μ g / L ,( 0. 66±0. 19 ) hand ( 0. 70±0. 29 ) h ,( 46. 11±32. 32 )
    hand ( 61. 28±93. 69 ) h ,( 13. 31±2. 63 ) μ g · h
    -1 · L -1 and (
    13. 10±2. 20 )
    mg
    · h
    -1 · L -1 ,
    respectively.Conclusion Theresultsshowthatthetwoformulationsarebioequivalent.The
    relativebioavailabilityofentecaviris ( 103. 3±14. 0 ) %.
    Mean platelet volume is associated with carotid atherosclerosis and both of them could predict cardiovascular events in patients with hypertension
    2016, 37(12):  1470.  doi:10.3969/j.issn.1007
    Asbtract ( 381 )  
    Related Articles | Metrics
    Objective To evaluate the correlation between mean platelet volume (MPV) and carotid intima media thickness (IMT) and both of them for prediction of long-term cardiovascular events in patients with hypertension. Methods 415 patients with hypertensive were consecutively enrolled. IMT and MPV on baseline were measured and recorded. The patients were followed up for about 5 years and cardiovascular events was recorded．Results In these subjects, the value of MPV and IMT were respectively 11.98 ± 0.47fL and 0.89 ± 0.25mm. Correlation analysis showed that MPV was respectively and positively related with IMT,LDL-C and WBC（r=0.407，P<0.001; r=0.163，p=0.013；r=0.215，p＜0.001 respectively）. During a follow-up period of about 5 years, 86 cardiovascular events were recorded. Receiver operating characteristic（ROC） analysis showed that AUC of MPV was 0.819(95％CI：0.768-0.870；P＜0.001)and AUC of IMT was 0.872(95％CI：0.824-0.920；P＜0.001) for predicting the long-term risk of cardiovascular events. Conclusion MPV positively associated with IMT. Both MPV and IMT could predict long-term cardiovascular events in patients with hypertension.
    Pediatric nursing -- the influence of comprehensive nursing intervention on the length of stay and the satisfaction of family members of children with severe pneumonia
    2016, 37(12):  1474.  doi:10.3969/j.issn.1007
    Asbtract ( 401 )  
    Related Articles | Metrics
    Objective: to analyze the clinical symptoms of children with severe pneumonia after comprehensive nursing care. Methods: our hospital in 2011 March to 2013 march during the 60 cases of patients with severe pneumonia were symptomatic treatment of finishing, the randomly allocated according to the principle of distribution, divided into test group and control group, 30 patients in each group, at the end of the treatment period, the control group take routine treatment and test group, application of comprehensive nursing intervention on treatment and nursing care of means to carry out care. After the same course of treatment, the recovery time of the symptoms of the patients were collected, and the parents of the patients were investigated. Results: the average time of hospitalization in the experimental group was better than that of the control group, the length of hospital stay was 12.2 + 3.2 days and 16.2 + 3.3 days. Its time was less than 0.05 P, with statistical significance. In the patients' parents' satisfaction on nursing, the satisfaction rate of the two groups was 100% and 88%, respectively, and the data was less than 0.05, which was statistically significant. Conclusion: In treatment of children with severe pneumonia in comprehensive nursing treatment information analysis, and for parents of nursing method to carry on the analysis, it can be see that the comprehensive nursing can effectively shorten time of treatment in children with, in clinical application worth.
    Children with severe hand, foot and mouth disease YiSiLuo before and after the treatment of LDH, CK, CK - MB, NE changes and significance
    2016, 37(12):  1477. 
    Asbtract ( 470 )  
    Related Articles | Metrics
    objective: Explore YiSiLuo er before and after treatment in children with severe hand, foot and mouth disease lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase isoenzyme (CK - MB), norepinephrine (NE) level changes and clinical significance.Methods: a retrospective analysis of our hospital in December 2013 to December 2014 were the clinical data of 105 cases of children with severe hand, foot and mouth disease, set as observation group, give YiSiLuo treatment.Choose 103 cases of healthy children as control group.Observation group of patients before and after treatment of lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase isoenzyme (CK - MB), norepinephrine (NE) level changes, and analyzed.Results: the observation group of LDH, CK, CK - MB, NE levels were significantly higher than that of control group, P < 0.05).Compared with before treatment, YiSiLuo observation group after treatment of children with LDH, CK, CK - MB, NE were a marked decline in the level, all P < 0.05.Conclusion: YiSiLuo, treatment of children with severe hand, foot and mouth disease can significantly improve the myocardial enzyme levels and norepinephrine levels, effectively relieve myocardial injury.
    Clinical diagnosis and treatment of cerebral hemorrhage after cerebral infarction and its effect analysis
    2016, 37(12):  1480.  doi:10.3969/j.issn.1007
    Asbtract ( 389 )  
    Related Articles | Metrics
    Objective: to analyze and discuss the clinical diagnosis and treatment of cerebral infarction actual cerebral hemorrhage. Methods: 100 cases of cerebral infarction after the March 2014 ~2016 year in January in our hospital bleeding patients, these patients were randomly divided into two groups: control group and observation group, the observation group of patients surgical treatment of small bone window hematoma, the control group underwent pore cranial drilling hematoma drainage treatment. Treatment effect were compared between two groups. Results: the total efficiency of the observation group (96%) was significantly higher than the control group (60%) (P<0.05), the mortality rate is not obvious difference between the two groups (P>0.05) of the two groups. Patients after treatment, recovery time, postoperative observation group, operation time, patients in the control group, postoperative complications and other related indicators were significantly better than P<0.05, with statistical significance. Conclusion: the study shows that small bone window hematoma. In addition to the effective treatment of cerebral hemorrhage after cerebral infarction, reduce the incidence of postoperative complications, shorten the time of surgery, it is worthy of clinical application and promotion.