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    25 December 2016, Volume 37 Issue 12
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    Studies on the correlation between cystatin C level and chronic heart failure in diagnosing and shortterm prognosis
    ZU Xiuguang1, ZHANG Shaojuan1, WANG Hongchao1, WANG Lixin2
    2016, 37(12):  1365-1369.  doi:10.3969/j.issn.10073205.2016.12.001
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    Abstract ] Objective ToinvestigatetherelationshipbetweencystatinC ( CysC ) leveland
    chronicheartfailure ( CHF ) indiagnosingandshort-termprognosis.Methods Onehundredand
    thirty-eightpatientswithCHFwerechoosedastheCHFgroup , 50caseshealthypeoplewere
    choosedasthecontrolgroup.N-terminalpro-B-typenatriureticpeptide ( NT-proBNP ), CysC ,
    serumcreatinine ( SCr ), urea , uricacid ( UA ), leftventricularejectionfraction ( LVEF ) were
    measuredinthecontrolgroupandtheCHFgroupbeforeandaftertreatment.TheCHFgroup
    wasfollowedupfor6monthstorecordall-causemortality , rehospitalizationforCHFandmajor
    cardiovascularevents ( heartfailure , acutecoronary syndrome , arrhythmia associated with
    hemodynamicdisorder ) .Results ThelevelsofNT-proBNPandCysCoftheCHFgroupwere
    significantlyhigherthanthatofthecontrolgroup , andthevaluesweregraduallyincreasedwith
    theworseningofheartfunction.ThelevelofLVEFoftheCHFgroupwassignificantlylower
    thanthatofthecontrolgroup , andLVEFvaluewasgraduallyreducedwiththeworseningof
    heartfunction.NT-proBNP , CysCandUAbeforetreatmentweresignificantlyhigherthanthat aftertreatment , LVEF beforetreatmentwaslowerthanthataftertreatment.NT-proBNP ,
    CysC , ScrandUAoftheeventgroupwerehigherthanthatofthenongroup , LVEFoftheevent
    groupwassignificantlylowerthanthatofthenongroup.Logisticanalysisshowedthathighlevel
    ofCysC , highlevelofNT-proBNPandlowlevelofLVEF wereindependentriskfactorsfor
    recentcardiovascularadverseevents.Conclusion ThelevelofCysC , NT-proBNPandLVEFare
    closelyrelatedtoCHF , theycanreflecttheseverityofcardiacfunction.ThelevelofLVEF ,
    CysCandNT-proBNParecloselyrelatedtotheshort-termprogn
    Clinical effect of ticagrelor antithrombotic therapy on highrisk coronary patients with low response to Clopidogrel
    PENG Lingyun, DING Huaisheng, LI Yuan, XIAO Dayan, LIU Ankang, WANG Hui
    2016, 37(12):  1370-1373,1382.  doi:10.3969/j.issn.10073205.2016.12.002
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    [
    Abstract ] Objective Toinvestigatetheeffectsofticagrelorinhigh-riskcoronarypatients
    whohavehighon-treatmentplateletreactivity ( HTPR ) withclopidogrelafterpercutaneous
    coronaryintervention ( PCI ) .Methods Atotalof209patientswithstableorunstableanginawho
    hadbeenreceivingclopidogreltreatmentwereselected.VerifyNow P2Y12assay wasusedto
    detecttheplateletreactivity.HTPRwasdefinedasP2Y12reactionunits ( PRU ) ≥208.Subjects
    wererandomizedintoHTPRgroup ( n =97 ) andnon-HTPRgroup ( n =112 ) .Totally , 63patients
    inHTPRgroupprecededPCI , individualsreceivedPCIwithHTPRwererandomlyassignedinto
    clopidogreltreatmentgroup ( n =30 ) andticagrelortreatmentgroup (
    n =33 ), receivingeither
    additionalclopidogrel300mgorticagrelor180mgbeforecoronaryangiography.Allthepatients
    continuedwithclopidogrelorticagrelortreatmentafterPCI.Clinicalcharacteristicand PCI
    relatedparametersforsubjectswhounderwentPCIwererecorded.TroponinandPRUlevelswere
    determinedbeforeandafterPCI , postoperativebleedingandmajoradversecardiovascularevents rateswereassessedafterPCI.Results Nosignificantdifferencesofclinicalcharacteristicsand
    PCIrelatedparameters werefound betweentheclopidogreltreatmentgroupandticagrelor
    treatmentgroup ( P >0.05 ) .NodifferencewasobservedoftroponinandPRUlevels24hbefore
    PCI ( P >0.05 ) .TicagrelortreatmentremarkablyreducedthePRUandtroponinlevelsafterPCI
    incomparisonwithclopidogreltreatmentgroup ( P <0.05 ) .Therateofpostoperativebleeding
    wassimilarbetweenthetwogroups.However , theincidenceofmajoradversecardiovascular
    events1yearafterPCIwassignificantlylowerintheticagrelorgroupcomparedtotheclopidogrel
    group ( P <0.05 ) .Conclusion Modifyingantiplatelettreatmenttoticagrelorinhigh-riskcoronary
    patientswithHTPRtoclopidogrelsignificantlyinhibitsplateletactivity , decreasestroponinlevel
    andreducestheincidenceofadversecardiovasculareventsafter1yearsofPCI.
    Effects of Artesunate on DNMT1 expression in highrisk MDS cell strain of SKM-1
    WANG Ying， NIU Zhiyun， XING Lina， QIAO Shukai， PAN Ling*
    2016, 37(12):  1374-1378.  doi:10.3969/j.issn.10073205.2016.12.003
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    [
    Abstract ] Objective Toobservetheeffectsofartesunate ( ART ) ongeneexpressionlevels
    ofDNMT1byusingSKM-1cellsastheresearchobject , andprovidelaboratoryevidenceinvitro
    fortheusageofARTinMDStreatment.Methods AfterbeingtreatedwithART ( 1 , 5and10
    μ mol
    / L ), DNMT1mRNAchangesinSKM-1cellswereobservedwithRT-PCR , andtheprotein
    expressionchangeswereobservedwith WestBlot.Then , theexpressionchangesofp15INK4b ,
    theDNMT1targetinggenewereobservedbyusingreal-timequantitativeRT-PCR , andthe
    changesofp15INK4bpromoter methylationstate wereobservedbyusing methylationPCR.
    Results AfterbeingtreatedwithART ( 1 , 5and10 μ mol
    / L ), thedifferencewasstatistically
    significantforDNMT1geneexpressioninSKM-1cellscomparedwithcontrolgroup ( P <0.05 ),
    buttherewasnosignificantdifferenceinthethreedosegroups ( 1 , 5and10 μ mol
    / L )(
    P >0.05 )  AstoDNMT1proteinexpression , comparedwith5 μ mol
    / Lgroup , therewassignificantlylower
    intheothertwogroups ( 1and10 μ mol
    / L )(
    P <0.05 ), andalsosignificantlylowerthanthatin
    controlgroup ( P <0.05 ) .Howevertherewasnosignificantdifferenceamongtheothergroups
    (
    P >0.05 ) .AfterSKM-1cellsbeingtreatedwithARTfor3h , 6hand12h , comparedwith
    controlgroup , thedifferenceofDNMT1geneandproteinexpressionsinthethreegroups (
    3h , 6
    hand12h ) wassignificant ( P <0.05 ) .Besides , thedifferenceofgeneexpressionbetweenthe
    twogroups ( 3h , 6h ) andthe12hgroupwasalsosignificant ( P <0.05 ) .Buttherewasno
    significantdifferentofproteinexpressioninothertreatedgroups ( P >0.05 ) .AfterSKM-1cells
    beingtreatedwithART , p15INK4BmRNAlevelofSKM-1cellsinthethreegroups ( 5and10
    μ mol
    / Lgroups , anddecitabinegroup ) wasstatisticallyhigherthanthatincontrolgroup (
    P <
    0.05 ), withthelevelin10 μ mol
    / Lgroupthehighestinthefivegroups , andthesignificant
    differencewasonlyfoundbetween10 μ mol
    / Lgroupandthefourgroups (
    controlgroup , 1 μ mol
    group , 5 μ molgroupand decitabinegroup )( P <0.05 ) .Afterbeingtreated with ART ,
    p15INK4bpromotermethylationlevelwasdecreasedinSKM-1cells , butthedifferencewasnot
    significant ( P >0.05 ) .Onthecontrary , thelevelofpromoterunmethylationstateinARTgroup
    wasincreasedcomparedwithtwoothergroups ( controlgroupandthedecitabinegroup )( P <
    0.05 ) .Conclusion ART can restorethe expression of p15INK4b byinhibit
    Effect of changes in dietary fat content on the ghrelin levels in diabetic rats
    CHEN Yunxia, GAO qian*, LIU Chunyan, ZHAO Shuling
    2016, 37(12):  1379-1382.  doi:10.3969/j.issn.10073205.2016.12.004
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    [
    Abstract ] Objective Tostudytheregulationofdietaryfatindiabeticratsontheweight ,
    differentpartsofthefatandghrelin.Methods SixtymaleSDratsweredividedintotwogroups
    randomly : 15normalcontrolratsand45testrats.Thetestratswerefedwithhighfatdietfor
    eightweeksandasingleintraperitonealinjectionofstreptozotocin ( STZ , 30mg /
    kg
    ) toestablish
    ananimalmodelofdiabetes.36diabeticratmodelwassuccessfullyestablished.Thediabeticrats
    wererandomlydividedintofollowinggroups : 18generaldietdiabeticratsand18high-fatdiet
    diabeticrats.Thenormalcontrolratsandgeneraldietdiabeticratswerefedwithgeneraldiet.The
    high-fatdietdiabeticratswerefedwithhigh-fatdiet.Aftersixweeks , allratswerekilled.Blood
    andadiposetissuesampleswerecollectedinallrats.Serum ghrelinwasdetectedbyenzyme-
    linkedimmunoassay.Results Thegeneraldietdiabeticratsandhigh-fatdietdiabeticratswere
    significantlyhigherin weight , epididymalfat , epinephrinefatand mesentericfatthannormal
    controlrats , andweresignificantlylowerinplasmaghrelinconcentrationthannormalcontrol
    rats.Conclusion Changesindietaryfatcontentplayaregulatoryroleonlevelsofghrelinin
    plasmathataffectweightandenergyintake.
    Study on the efficacy of flupenthixol melitracen combined with Weichang'an Pill in the treatment of patients with diarrheapredominant irritable bowel syndrome
    GAO Guangzhou, YAO Hongmei， ZHANG Xiaoming, YANG Yang, ZHANG Jinzhuo， HAO Yingxia*
    2016, 37(12):  1383-1386,1390.  doi:10.3969/j.issn.10073205.2016.12.005
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    [
    Abstract ] Objective Toobservetheclinicalefficacyofflupenthixolmelitracencombined
    with Weichang'aninthetreatmentdiarrhea-predominantirritablebowelsyndrome ( IBS-D ) .
    Methods Atotalof77IBS-Dpatientswasdividedrandomlyintocontrolgroupandexperimented
    group.Thepatientsofcontrolgroupweretreatedwith Weichang'anPill0.8gthreetimesper
    day.Onthebasisofthetreatmentofcontrolgroup , thepatientsofexperimentalgroupwere
    givenflupenthixolmelitracen10.5 mgafterbreakfastandlunchperday.Thepatientswere
    evaluatedbythe Hamilton AnxietyScale ( HAMA ), Hamilton Depression Scale ( HAMD ),
    abdominalpainanddiarrheasymptomscoreswhenenrolledandwerefollowedupatthefourth
    week.Theadverseeffects wereobservedandrecorded.Results Beforethetreatment , the
    subjectsinthe2groupswerematchableintheirdepressionandanxietyratios , andtherewereno
    statisticaldifferencebetweenthetwogroupsinHAMA , HAMDandabdominalpainanddiarrhea symptomscores ( all P >0.05 ) .Afterfourweekoftreatment , theefficacyrateofabdominalpain ,
    diarrheaandtotaleffectiveratesoftreatmentgroupwerehigherthanthoseofcontrolgroup.The
    differenceswerestatisticallysignificant ( P <0.05 ) .Thescoresof HAMA and HAMD of
    experimentalgroupweresignificantlylowerthanthoseofcontrolgroup ( P <0.05 ) .Conclusion
    Flupenthixol melitracen combined with Chinese medicine Weichang'an Pill demonstrates
    significantefficacyintheimprovementofdepression , anxietyandmainsympto
    Clinical observation of insulin determir combined with metformin in type 2 diabetes patients
    YANG Liu, TIAN Li, MENG Xianjie, LIU Hongmei, ZHANG Lihua, YE Chunfang
    2016, 37(12):  1387-1390.  doi:10.3969/j.issn.10073205.2016.12.006
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    [
    Abstract ] Objective Toobservetheefficacyandsafetyofinitiatinginsulintherapywith
    insulindetemirinoralantidiabeticdrugmetformin-treatedpatientswithtype2diabetesmellitus
    ( T2DM ) whosebloodglucoseisnotyetuptothestandard.Methods SixtysubjectswithT2DM
    wererandomlydividedintotwogroups , insulindetermircombiningwith metformin ( treatment
    group ) and glimepriridecombining with metformin ( conrtolgroup ) .Thistreatmentruly
    monitoredhemoglobinA 1 c , 7-pointbloodglucose , bodyweight , hypoglycemicevent , allergic
    reaction.Duringthe32-week-treatment , thedosagesofmedicinewereadjustedaccordingtoself-
    recordeddaily7-pointbloodglucose.Thisclinicalobservationistoevaluatetheefficacyandsafety
    ofinsulindetermir.Results The7-pointbloodglucoseofthe2groupsaftertreatmentwere
    significantlylowerthanthosebeforetreatmen ( P <0.05 ) .Thetreatmentgroupwaslowerthan
    thecontrolgroup ( P <0.05 ), butthere'snosignificantdifference (
    P >0.05 ) .Therewasno
    hypoglycemiceventorallergicreaction duringthetreatment.Conclusion Insulin detemir
    combinedwith metformincertainlyreducebloodglucoseinT2DM patientseffectively.Insulin
    detemircombinedwithmetformindoesnotincreasethepatient'sbodymass , nordoesitincrease
    theincidenceofhypoglycemiceventsandallergicreactions
    The correlation between radiotherapy sensitization of βelemene and tumor angiogenesis
    HUANG Jiafu
    2016, 37(12):  1391-1393.  doi:10.3969/j.issn.10073205.2016.12.007
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    [
    Abstract ] Objective Toexplorethecorrelationbetweenradiotherapysensitizationof β -
    elemeneandtumorangiogenesis.Methods Whentransplantedtumorshadaccumulatedfor0. 8-
    1. 0cm
    3 ,
    tumor-burdenednudemiceweredividedinto8groupsrandomly ( eachgroupforfive ),
    whichincludes : blankgroup , 25mg / kgdrugsgroup , 45mg / kgdrugsgroup , 100mg / kgdrugs
    group , theradiotherapygroup ( NaCl+radiotherapy ), 25mg
    / kgdrugs+radiotherapygroup , 45
    mg
    / kgdrugs+radiotherapygroup , 100mg / kgdrug+radiotherapygroup.
    β
    -elemenewasinjected
    accordingtodose , and NaClwasinjectedtoblankgroup.Volumedoublingtime ( VDT ) and
    enhancementfactor werecompared between groups.Theexpression ofvascularendothelial
    growthfactor ( VEGF ) andCD34werecomparedbetweengroups.Results VDTofB1 , C1and
    D1groupwerehigherthantheA1 , andVDTofD1groupwashigherthanB1 , C1group , which
    thedifferenceswerestatisticalsignificance ( P <0.05 ) .VDTofB2 , C2andD2groupwerehigher
    thanA2group , andD2andC2groupwerehigherthanB2 ,
    atthesametimeD2groupwashigher
    thanC2group , whichthedifferenceshadstatisticalsignificance
    ( P <0.05 ) .Thedifference
    betweenradiotherapygroupandno-radiotherapygroupwasnostatisticallysignificant ( P <0.05 ) .
    Thedoseof45 mg
    / kgand100 mg / kghadsensitizationeffect.Averageopticaldensityand
    Construction and evaluation of multidisciplinary nursing team in elderly patients with hip fracture
    DONG Yunfang1, LI Yujia2, YAN Xiaoli2, CHEN Caizhen2, LI Dongzheng3, ZHANG Xiuguo4*
    2016, 37(12):  1394-1398,1406.  doi:10.3969/j.issn.10073205.2016.12.008
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    [ Abstract ] Objective To explore the establishment , management and effect of
    multidisciplinarycareteamintheelderlypatientswithhipfractureinthemultidisciplinemedical
    cooperationmode.Methods Amultidisciplinarynursingteamincludedepartmentoforthopedics ,
    respiration , cardiology , endocrinologywassetup.Divisionofresponsibilities , workflow , nurse
    schedulingand quality according to the multidisciplinary medicalcooperation mode were
    managed.Thepatient'ssatisfaction , caredefectsandtheoreticalknowledgeandtechnicallevel
    were evaluated and compared between before and after organization of multidisciplinary
    cooperationteam.Results Comparing withbeforeorganizationof multidisciplinarynursing
    team , thepatient'ssatisfaction ( P <0.05 ), thescoresoftheoreticalknowledge ( P <0.05 ),
    technicalqualifiedrate ( P <0.05 ) weresignificantlyimprovedandthecaredefectswasreduced
    (
    P <0.05 ) .Conclusion Multidisciplinarycareteamisanewnursingmodetoadapttothemulti
    disciplinehealthcarecooperationmodeandanewtypeofnursingcareforelderlypatientswith hipfracture.
    Application of quality control circles activities in the improvement of health education satisfaction of the neurology patients in hospital#br#
    PANG Ke, LIU Xin, LI Yi, DENG Yongmei*
    2016, 37(12):  1399-1401,1411.  doi:10.3969/j.issn.10073205.2016.12.009
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    [
    Abstract ] Objective Toimprovethehealtheducationsatisfactionoftheneurologypatients
    inhospital.Methods Thequalitycontrolcircles ( QCC ) groupwasestablish , and100patientsin
    hospitalrandomly wereselected , whom wereseperatedintocontrolgroupandexperimental
    group.Weconfirmedthethemeofthesurvey , followedbytheprocessofthePDCAcirculation ,
    analyzedtheimpactfactorsofthesatisfaction ofhealth education , tookreciprocalaction.
    Differenceofsatisfactionforbothgroups wascompared , andtheimprovementofpatients'
    satisfactionbyQCCwasobserved.Results Fiftysurveyquestionnairesweredistributedtoboth
    groups , 100% werecollected , thesatisfactionofcontrolgroupwashigherthantheexperimental
    group , whichissignificantdifferent ( P <0. 05 ) .ThetargetyieldrateoftheQCCwas118%and
    progressratewas21% , whichshowedgreateffectivenessoftheQCC.Conclusion TheQCCcan
    improvethehealtheducationsatisfactionoftheneurologypatientsinhospitaleffectively , can
    strengthentheenthusiasm , confidenceandteamcohension , canimprovetherelationshipbetween
    nursesandpatientsandthemanagementawarenessofthenurses.
    Effects of specific CTL which are activated by DC modified with IL27 gene and esophageal tumor lysate on esophageal carcinoma cell mitochondria membrane potential and cell apoptosis
    WANG Shaoqing1, ZHANG Wanyu2, WANG Dapeng3, WANG Shidong4, MI Yuan5, WANG Lei5*
    2016, 37(12):  1402-1406.  doi:10.3969/j.issn.10073205.2016.12.010
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    [ Abstract ] Objective Toexploretheeffectofspecificcytotoxiclymphocyte (
    CTL ) whichare
    activatedbydendriticcell ( DC ) modified withIL-27 geneandesophagealtumorlysateon
    esophagealcarcinomacellapoptosis.Methods After makingthe nude mice models with
    esophagealcancercellsuccessfully , the mice wereimmunized withspecific CTL whichare
    activatedbyIL-27genemodifiedDCloadedwithesophagealtumorlysate ( DC IL-27+Ag ) .Thecell apoptosisratewasanalyzedbyAnnexinV / PIstaining.Themitochondrialmembranepotential
    was measuredby Rhodamine123stainingandtheexpressionlevelofcaspase-3protein was
    detectedbyflowcytometry.Results Theratioofapoptosis , membranepotentialofmitochondria
    andexpressionofcaspase-3of5groupsshowedsignificantdifference ( P <0.05 ) .Theratioof
    apoptosisandcaspase-3proteinexpressioninDC IL-27+Ag group , DC IL-27 groupandDC naive group
    werehigherthanthoseinPBSgroup ( controlgroup ) .Themembranepotentialofmitochondriain
    DC IL-27+Ag group , DC IL-27 groupandDC naive groupwashigherthanthatinPBSgroup.Theratioof
    apoptosisandcaspase-3proteinexpressioninDC IL-27+Ag , group , DC IL-27 groupand , DC naive group
    werehigherthanthoseinTnaivegroup , butthemembranepotentialofmitochondriainDC IL-27+Ag
    group , DC IL-27 groupandDC naive groupwaslowerthanthatinTnaivegroup.Theratioofapoptosis
    andcaspase-3proteinexpressioninDC IL-27+Ag group , DC IL-27 group werehigherthanthosein
    DC naive group , butthemembranepotentialofmitochondriainDC IL-27+Ag group , DC IL-27 groupwas
    lowerthanthatin DC naive group.Theratioofapoptosisandcaspase-3proteinexpressionin
    DC IL-27+Ag group , were higherthanthosein DC IL-27 group , butthe membrane potentialof
    mitochondriainDC IL-27+Ag groupwaslowerthanthatinDC IL-27 group.Conclusion SpecificCTL ,
    activatedbyDCmodifiedwithIL-27geneandesophagealtumorlysate , efficientlyplaycytotoxic
    effectontumor-bearing miceinvivothroughreducingthemitochondrialmembranepotential ,
    initiatingth
    Clinnical efficacy of bronchial arterial infusion chemotherapy and embolization in the treatment of stage Ⅲ nonsmall cell lung cancer
    WANG Jiyun1， LI Ting2， YU Ke1， LI Wangang1*， TIAN Haoyin1， PEI Xiaodong1
    2016, 37(12):  1407-1411.  doi:10.3969/j.issn.10073205.2016.12.011
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    [
    Abstract ] Objective Toevaluatethecurativeeffectofthebronchialarterialinfusion
    chemotherapyandembolizationinstageⅢ non-smallcelllungcancer.Methods Onehundred
    andtwentycasesofstageⅢ non-smallcelllungcancerwererandomlydividedintoobservation
    groupandcontrolgroup.Theobservationgroupwasgiven4cyclesbronchialarterialinfusion
    chemotherapyandembolizationofiodizedoil , thenthebronchialarterywasembolismedwith
    gelfoamcompletelyattheendofthefourthcycle.Thecontrolgroupwasgivenroutinebronchial
    arterialinfusionchemotherapy.Thenitwascomparedoftwogroupsthatthecurativeeffect , side
    effects , andassesstheclinicalvalueofbronchialarteryperfusionchemotherapyembolism.
    Results Thecompleteremission ( CR ) andpartialremission ( PR ) intheobservationgroupand
    controlgroupwere41cases ( 68. 3% ) and32cases ( 53. 3% ) respectively.Progressionfreesurvialof patientsintheobvervationgroupwere ( 9. 8±1. 6 ) monthsand ( 5. 1±0. 8 ) months , themedian
    survivalwere ( 17. 5±2. 2 ) monthsand ( 11. 8±1. 5 ) monthsrespectively , threeindicatorshave
    statisticalsignificance ( P <0.05 ) .Observationgroup1 , 2 , 3 , 5yearssurvivalrate ( % ) 70. 7 ,
    47. 4 , 13. 6 , 8. 8 , andcontrolgroupin59. 7 , 32. 4 , 14. 6 , 9. 5 ; Therewassignificantdifferencefor
    1 , 2yearsurvivalrate ( P <0.05 ), andnostatisticalsignificancefor3 , 5yearsurvivalrate ( P >
    0.05 ); Totaladversereactionratewas35. 6% , 35. 6% , withnostatisticalsignificance P >0.05.
    Conclusion BronchialarterialinfusionchemotherapyandembolizationforstageⅢnon-smallcell
    lungcancerinthenearfuturecurativeeffectissuperiortopurebronchialarterialinfusion , and
    withoutincreaseofsideeffects.Thismethodisworthyofclinicalpromotion.
    Clinical effect of different dose of ω3 polyunsaturated fatty acids in postoperative patients with esophagus cancer
    GONG Shunsong，MING Wei
    2016, 37(12):  1412-1415,1457.  doi:10.3969/j.issn.10073205.2016.12.012
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    [ Abstract ] Objective Toinvestigatetheeffectofdifferentdosesofω-3polyunsaturatedfatty
    acidoninflammatoryfactors , nutritionalstatusandpostoperativecomplicationsinpatientswith
    esophagealcarcinoma.Methods Ninety-twopatients wtihesophaguscancer wererandomly
    dividedintoacontrolgroup ( 32cases ), experimentalgroup1 ( 30cases ) andtheexperimental
    group2 ( 30cases ) .Allpatientsweregiven6daysofparenteralnutritionsupporttreatment
    , and
    thenweregivenliquiddietafterrecoveryofgastrointestinalfunction.Controlgroupwasgiven
    saline100 mL / d , the experimentalgroup 1 weretreated with saline 50 mL / d and ω-3
    polyunsaturatedfatty acid 50 mL / d , the experimental group 2 were treated with ω-3
    polyunsaturatedfattyacid100 mL / d , allthetreatmentcourse wasone week.Procalicitonin
    (
    PCT ), C-reactiveprotein ( CRP ) andinterleukin-6 ( IL-6 ), albumin ( Alb ), lymphocyte ( LYM ),
    prealbumin ( PA ) andtransferrin ( TFN ) ofpatientswerecollectedandcomparedonpreoperative day1 , postoperativeday1 , andpostoperativeday7.Thedrugreactionsandtheoccurrenceof
    postoperativecomplicationswererecorded.Results Onpostoperativeday7 , thePCT , CPRand
    IL-6ofexperimentalgroup1andexperimentalgroup2werelowerthanthatofconrolgroup
    ( P <0.05 ), the PCT , CPR andIL-6 ofexperimentalgroup2 werelowerthan that of
    experimentalgroup1 ( P <0.05 ), theLYM ofexperimentalgroup1andexperimentalgroup2
    werehigherthanthatofconrolgroup ( P <0.05 ), theLYMofexperimentalgroup2werehigher
    thanthatofexperimentalgroup1 ( P <0.05 ) .Therewere3casesofwoundinfection , 2casesof
    pulmonaryinfection , 1casesofanastomoticleakageincontrolgroup , 3casesofwoundinfection
    inexperimentalgroup1 , 3casesofpulmonaryinfectionand1casesofincisioninfectionin
    experimentalgroup2.Theincidenceofcomplicationswas3. 33% ( 1 / 30 ) inexperimentalgroup2 ,
    whichwaslowerthanthatincontrolgroup21. 88% ( 7 / 32 ) andtheexperimentalgroup2 ( P <
    0.05 ) .Theincidenceofcomplicationswerenotstatisticallysignificant ( P >0.05 ) .Conclusion ω-
    3polyunsaturatedfattyacidscanreducetheinflammatoryreactioninpatientswithesophageal
    cancer , andimprovethenutritionalstatusofpatientsaftersurgery.Theapplicationoflargedose
    ismoreobvious , andcanreducetheincidenceofpostoperativecomplications.
    Effect of SuperPath minimally invasive incision total hip arthroplasty on femoral head necrosis and the quality of life
    REN Dongwei, YANG Gejun*, ZHAO Hualei, ZHA Jianyue, LU Shun, XU Yongsheng
    2016, 37(12):  1416-1419.  doi:10.3969/j.issn.10073205.2016.12.013
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    [
    Abstract ] Objective ToexplorethetherapeuticeffectofSuperPathincision minimally
    invasivetotalhiparthroplastyforfemoralheadnecrosispatientsandtheirqualityoflife.Methods
    Fourty-twopatientswithfemoralheadnecrosiswererandomlydividedintocontrolgroupand
    experimental group.Control group patients were received total hip arthroplasty , and
    experimentalgroupwerereceivedSuperPathincisionminimallyinvasivetotalhiparthroplasty.To
    evaluatethetherapeuticeffect , weanalyzetheHarrisscoreofpatientsbeforeand1months , 2
    monthsand3monthsaftersurgeryandcomparetwolegslengthdifference , andWOMACscore
    ofpatientsbeforeandaftertreatmenttoevaluatethequalityoflife.Results Afterthesurgery ,
    patients'Harrisscoresweresignificantlyimproved ( P <0.05 ); whileWOMACscoresofpatients
    weresignificantlylowerthan those beforetreatment ( P < 0.05 ) .There were significant
    differencesbetweenthetwo groupsatdifferenttimes.Howeverthere was no significant
    differencebetweenthegroups ( P >0.05 ) .Thetwolegslengthdifference , thelengthofstayand
    thedurationbetweentheoperationandthefirsttimeoutofbedofpatientsintheexperimental groupweresignificantlyshorterthanthoseinthecontrolgroup ( P <0.05 ) .Conclusion Treating
    femoralheadnecrosis with SuperPathincision minimallyinvasivetotalhiparthroplastycan
    effectivelyreducesurgicaltrauma , andimprovethequalityoflifeofpatients.Itisworthyof
    promotion.
    Vertebral fixation combined with fenestration in the treatment of thoracolumbar vertebral fractures with spinal canal invasion
    LI Dongfeng, LIU Fajing, HU Chengdong, HUO Xiwei, LI Yanfei
    2016, 37(12):  1420-1423,1427.  doi:10.3969/j.issn.10073205.2016.12.014
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    [
    Abstract ] Objective ToexplorethetherapeuticeffectofSuperPathincision minimally
    invasivetotalhiparthroplastyforfemoralheadnecrosispatientsandtheirqualityoflife.Methods
    Fourty-twopatientswithfemoralheadnecrosiswererandomlydividedintocontrolgroupand
    experimental group.Control group patients were received total hip arthroplasty , and
    experimentalgroupwerereceivedSuperPathincisionminimallyinvasivetotalhiparthroplasty.To
    evaluatethetherapeuticeffect , weanalyzetheHarrisscoreofpatientsbeforeand1months , 2
    monthsand3monthsaftersurgeryandcomparetwolegslengthdifference , andWOMACscore
    ofpatientsbeforeandaftertreatmenttoevaluatethequalityoflife.Results Afterthesurgery ,
    patients'Harrisscoresweresignificantlyimproved ( P <0.05 ); whileWOMACscoresofpatients
    weresignificantlylowerthan those beforetreatment ( P < 0.05 ) .There were significant
    differencesbetweenthetwo groupsatdifferenttimes.Howeverthere was no significant
    differencebetweenthegroups ( P >0.05 ) .Thetwolegslengthdifference , thelengthofstayand
    thedurationbetweentheoperationandthefirsttimeoutofbedofpatientsintheexperimental groupweresignificantlyshorterthanthoseinthecontrolgroup ( P <0.05 ) .Conclusion Treating
    femoralheadnecrosis with SuperPathincision minimallyinvasivetotalhiparthroplastycan
    effectivelyreducesurgicaltrauma , andimprovethequalityoflifeofpatients.Itisworthyof
    promotion.
    Effect and clinical efficacy of lienal polypeptide injection on immune function of cervical cancer patients with neoadjuvant chemotherapy
    HAN Hua1， WEI Qiang2， QIU Gang3， LI Jie1， YAN Ping1
    2016, 37(12):  1424-1427.  doi:10.3969/j.issn.10073205.2016.12.015
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    [ Abstract ]
    Objective Toobservetheeffectandclinicalefficacyoflienalpolypeptideinjection
    onimmunefunctionofcervicalcancerpatients with neoadjuvantchemotherapy.Methods
    Randomlyselected52casesofcervicalcancerpatients withneoadjuvantchemotherapy were
    dividedintocontrolgroupandstudygroup.Patientsinthecontrolgroup weretreated with
    paclitaxelplusnedaplatinchemotherapy , whilethepatientsinthestudygroupweretreatedwith
    chemotherapyandLienalPolypeptideInjection.Theshort-term efficacy , adversereactionand
    immunefunction werecomparedbetweenthe2groups.Results Theresponserateofstudy
    groupandcontrolgroupwas65. 4% and61. 5%respectively , withoutsignificantdifference ( P >
    0.05 ) .Thearrestofgastrointestinalreaction , bonemarrow , neurotoxicityandimpairmentof
    liverfunctionofthestudygroupweresignificantlylowerthanthatinthecontrolgroup , andthe
    differencewasstatisticallysignificant ( P <0.05 ) .ThemeanvaluesofCD3
    + ,
    CD4
    + ,
    CD8
    +
    and
    NK cellsinthestudy group wereimprovedto certain differentdegrees , with statistical
    significancecompared withthecontrolgroup ( P <0.05 ) .Conclusion Thelienalpolypeptide
    injectioncanimprovetheimmunefunction , reducethesideeffectsofchemotherapy , andhasthe effectofreducingtoxicityandincreasingtheefficiency.
    The clinical research of biomimetic electrical technique in prevention of  lower limb deep venous thrombosis in eldly patients after gynaecological laparoscope
    ZHANG Bin， GUO Lina， LI Wenjing
    2016, 37(12):  1428-1431,1436.  doi:10.3969/j.issn.10073205.2016.12.016
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    [ Abstract ] Objective Toassessthevalueofbiomimeticelectricaltechniqueintheprevention
    oflowerdeepvenousthrombosisineldlypatienaftergynaecologicallaparoscope , andthereby
    exploreasafeandeffectiveprophylaxismethod.Methods Thisstudyincluded120eldlypatients
    over60yearsofageaftergynaecologicallaparoscope.Thepatientsweredividedrandomlyinto
    groupA ( routinenursinggroup ), groupB (
    elasticsockgroup ) andgroupC ( biomimeticelectrical
    techniquegroup ) .Thebloodflow velocityandchangesinhemodynamicsofthepatientwere
    determinedandcomparedamongthe3groups.Results Prothrombintime ( PT ), activatedpartial
    thromboplastintime ( APTT ) ofgroupCarehigherthanthatofgroupAandBin3daysafter
    operation , D-dimerislowerthangroupAandB.PT , D-dimerofgroupBishigherthanthatof
    groupA ( P <0.05 ) .APTTofgroupBwasnostatisticallysignificantdifferencecomparedwith
    groupC ( P >0.05 ) .Plasmaviscosity , erythrocytedepositedandplateletadhesionrateofgroupC
    islowerthanthatofgroup AandgroupB.Bloodplasmaviscosity , Bloodplasmaviscosity ,
    erythrocytedepositedandplateletadhesionrateofgroupBarelowerthanthatofgroupA ( P <
    0.05 ) .SharesalwaysvenousbloodflowvelocityofgroupCisgreaterthanthatofgroupAand groupB , groupBgreaterthanthatofgroupA (
    P <0.05 ) .Stocktotalveindiameterofthree
    groupsvaluedifferenceshavenostatisticalsignificance ( P >0.05 ) .Conclusion Biomimetic
    electricaltechniqueineldlypatientsaftergynaecologicallaparoscopecanacceleratethebloodflow
    velocityinthelowerlimbdeepveinsandimprovebloodheightglutinousconditiontoeffectively
    preventdeepvenousthrombosis.
    The application value of fetal umbilical artery and middle cerebral artery resistance index in predicting fetal hypoxia
    CHEN Jianghong1, WANG Na1, HUANG Nailei1, GAO Yong2*
    2016, 37(12):  1432-1436.  doi:10.3969/j.issn.10073205.2016.12.017
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    [
    Abstract ] Objective Todiscusstheapplicationvalueoffetalumbilicalarteryandmiddle
    cerebralarteryresistanceindexinpredictingfetalhypoxia.Methods Atotalof120pregnant
    womeninhospitalwasselectedanddividedintocontrolgroupandobservationgroup , thecontrol
    groupwith62casesofnormalpregnancy , theobservationgroupwith58casesoffetalhypoxia
    pregnancy , theuseofcolorDopplerultrasounddetectionoffetalumbilicalartery , middlecerebral
    artery , pulsatilityindex (
    PI ), resistanceindex ( RI ) andpeaksystolicandenddiastolicvelocity
    ratio ( S / D ), and calculatetheircorrespongdingratio , andthetwo groups ofdata were
    statisticallyanalyzed.Results Theumbilicalarteryresistanceindexintheobservationgroupwas
    significantlyhigherthanthatinthecontrolgroup ( P <0.01 ) .The middlecerebralartery
    resistanceindex wassignificantlylowerthanthatincontrolgroup ( P <0.01 ) .Theratioof
    PI umbilicalartery / middlecerebralartery , RI umbilicalartery / middlecerebralartery andS / D umbilicalartery / middlecerebralartery offetalumbilical 0.01 ), andhadagooddiagnosiseffectonthesensitivity , specificityand Youdenindexby
    PI umbilicalartery / middlecerebralartery >1. 00 , RI umbilicalartery / middlecerebralartery >1. 00andS / D umbilicalartery / middlecerebralartery >
    0. 72.Conclusion Resistanceindexesandtheircorrespondingratiooffetalumbilicalarteryand
    middlecerebralarteryinpredictingfetalhypoxiahasimportantvalue , which wascapableof
    predictingfetalhypoxiaandotheradversepregnancyphenomenons , andcandetecttheearly
    abnormalitiestoreduceneonatalmortalityrate , guidetheclinicalintervention , improvethe
    qualityofnewbornbirth.
    Clinical observation on ultrasoundguided with equal small does ropivacaine of different concentrations in brachial plexus block
    DING Qingmin, ZHANG Haiqing
    2016, 37(12):  1437-1440.  doi:10.3969/j.issn.10073205.2016.12.018
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    [
    Abstract ] Objective Toobservetheefficacyandsafetyofultrasound-guidedwithequal
    smalldoesropivacaineofdifferentconcentrationsinbrachialplexusblock.Methods Sixty-three
    casesofupperlimbsurgerywithASA Ⅰ-Ⅱ electiveinbrachialplexusblockwereselected.
    Accordingtothedifferentanestheticconcentration , thepatientsweredividedinto A , B , C
    groups , 20patientsingroupA , 22casesingroupB ,
    21casesingroupC.GroupA wasgiven
    0. 375%ropivacaine26. 67 mL , groupB wasgiven0. 50% ropivacaine20. 00 mL , groupC was
    given0. 75%ropivacaine13.
    33mL.Theonsettimeofsensoryblock , thedurationofanalgesia ,
    thetotalnumberofblocksegmentandtotalblock , theonsetofmotorblock , therecoverytime
    andtheincidenceofcomplicationsin3groupswereobservedandrecorded.Results Threegroups
    ofpatientsweresatisfiedwiththeeffectofanesthesia.Sensoryblockadetimeandanalgesiceffect
    timeofgroupA werelongerthanBandCgroup , thetotalnumberofblocksectionwasmore
    thangroupB , C , thedifferenceswerestatisticallysignificant ( P <0.05 ) .Completeblockrateof
    threegroupswerenotstatisticallysignificant ( P >0.05 ) .ModifiedBromagescoreof3groupwere abovetwopoints.Threegroupswithin15 min movementcompletelyblockwereabove95%.
    GroupAmotionblockworktimewassignificantlylongerthanBandCgroup ( P <0.05 ) .GroupC
    campaignblockrecoverytimeis muchshorterthangroup A andB ( P <0.05 ) .Noserious
    complicationsoccurredin3group.IngroupA , 3patientshadchestdistress , andtheheartrate
    wastooslow.Conclusion Ultrasound-guidedbrachialplexusblockwithsmalldoesropivacaine
    canobtainsatisfactoryblockeffect.Withtheincreaseofconcentration , theonsettimeisshorter.
    Withtheincreaseofcapacity , theblockisbroader , andthedurationoftheblockislonger
    , but
    theincidenceofadversereactionsarealsolikelytoincrease.0. 375%-0. 50% ropivacaine ( 100
    mg
    ) ismoresuitablefortheultrasound-guidedbrachialplexusblock
    Studies on human pharmacokinetics and bioequivalence of entecavir dispersible tablet
    MA Jie, DONG Zhanjun*, BAI Wanjun, SONG Haojing, WU Yin, ZHI Xuran
    2016, 37(12):  1441-1444.  doi:10.3969/j.issn.10073205.2016.12.019
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    [
    Abstract ] Objective Toevaluatethebioequivalenceof2kindsofentecavirpreparationsin
    humanbodies.Methods Therandomized , crossed-overstudy wasconductedin20 healthy
    volunteers.AfterAsingleoraldoseofentecavirhydrochloridetestandreferencepreparations
    (
    containing0. 5mgentecavir ), thedruglevelsinplasmaweredeterminedbyhighperformance
    liquid chromatography-tandem mass spectrometry.The pharmacokinetic parameters were
    calculatedwithDAS3. 2. 7software , thenbioequivalenceofthetwopreparationswasevaluated.
    Results ThepeakconcentrationsC max , t max , t 1 / 2 and AUC 0-72h ofthe2formulations were
    (
    4. 41±1. 02 ) μ g / Land ( 4. 36±0. 89 ) μ g / L ,( 0. 66±0. 19 ) hand ( 0. 70±0. 29 ) h ,( 46. 11±32. 32 )
    hand ( 61. 28±93. 69 ) h ,( 13. 31±2. 63 ) μ g · h
    -1 · L -1 and (
    13. 10±2. 20 )
    mg
    · h
    -1 · L -1 ,
    respectively.Conclusion Theresultsshowthatthetwoformulationsarebioequivalent.The
    relativebioavailabilityofentecaviris ( 103. 3±14. 0 ) %.