Table of Content

25 March 2017, Volume 38 Issue 3

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The predictive value of GRACE score on type 1 cardiorenal syndrome in patients with nonST segment elevation acute coronary syndrome

WANG Yanbo1, MENG Haiyun2, GU Xinshun1*, HAO Guozhen1, JIANG Yunfa1, FU Xianghua1

2017, 37(3):  249-252,257.  doi:10.3969/j.issn.10073205.2017.03.001

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［Abstract］ Objective〖HTSS〗〓To evaluate the predictive effect of the global registry of acute coronary events(GRACE) score on type 1 cardiorenal syndrome(CRS) in patients with nonST segment elevation acute coronary syndrome(nonST ACS).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and fiftyone cases patients were divided to CRS group 12 cases and nonCRS group according to the incidence of type 1 CRS. The baseline clinical characteristics and the procedure of coronary interventions were recorded and compared. The incidence of major adverse events was followed up. Receiver operaling characleristics(ROC) curve was used to identify predict effect of GRACE score on type 1 CRS in patients with nonST ACS.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓More patients with nonST segment elevation myocardial infarction were in the CRS group, and both GRACE and CRUSADE scores were higher in the CRS group(P＜005). The incidence of sudden death before admission was higher(P＜005) and the level of hematokrit was lower(P＜005) in CRS group compared to the nonCRS group. The peak levels of creatine kinase and troponin I were higher in CRS group than those in the nonCRS group, while the levels of left ventricular ejection fraction and E/e′ were lower(P＜005). The level of diastolic blood pressure in CRS group was lower(P＜0.05). Logistic regression analysis showed that the GRACE and CRUSADE scores were indepandent risk factors of type 1 CRS in patients with ACS during the hospitalization(P＜005). The area under the ROC curve for ratio was 0.906(95% CI  0.853-0.960，P＜0001).  At a cutoff point of 128, the value of GRACE score exhibited 91.7% sensitivity and 80.6% specificity for detecting type 1 CRS in patients with nonST ACS.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The value of GRACE score could predict type 1 cardiorenal syndrome in nonST ACS patients，with high sensitivity and specificity.

Establishment of a mouse model of chronic renal vascular calcification

WANG Wenwei1， TIAN Lulu2， XIONG Yanwen3， CHEN Qijing2， PENG Wen4， YIN Peihao5*

2017, 37(3):  253-257.  doi:10.3969/j.issn.10073205.2017.03.002

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［Abstract］ Objective〖HTSS〗〓To establish vascular calcification mouse model derived from chronic kidney disease（CKD）.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Murine CKD was induced by oral dosing with adenine. 1,25(OH)2D3 and highphosphate diet were used to accelerate vascular calcification. Serum urea nitrogen, serum creatinine, uric acid, calcium and phosphate were measured. HE staining and Von kossa staining were used to examine the morphological changes in kidney and aorta, respectively.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After adenine dosing combined with 1,25(OH)2D3 and highphosphate diet, significant aortic calcification was detected in about 17% animals at 6 weeks, significantly increased serum urea nitrogen, creatinine, uric acid， serum calcium and phosphate were observed  and all model animals showed significant arterial wall thickening and increased medial elastic fibers.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓These data suggest that mice dosed orally with adenine in combination with 1,25(OH)2D3 and highphosphate diet were able to develop severe CKD and vascular disorder. The research provide a simple and stable mice modet to study vascular calcification in chronic kindney disease.


Effect of intensive atorvastatin before operation combined with full hydration therapy on contrast induced nephropathy in patients after PCI

LI Ran1， WANG Deliang1， WANG Wensu2

2017, 37(3):  262-265.  doi:10.3969/j.issn.10073205.2017.03.004

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［Abstract］  Objective〖HTSS〗〓To discuss the effect of intensive atorvastatin before operation combined with full hydration therapy on contrast induced nephropathy(CIN) in patients after percutaneous coronary intervention(PCI) .
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Ninetytwo cases of patients with coronary heart disease undergoing elective PCI surgery treated in our hospital were randomly divided into intensive group and conventional group, with 46 cases in either group. The intensive group were given intensive atorvastatin before operation combined with full hydration therapy, while the conventional group were given conventional atorvastatin combined with full hydration therapy. The changes of levels of serum creatinine(SCr),blood urea nitrogen(BUN) and urinary β2microglobulin(β2MG) at different moments and the incidence rates of CIN were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of SCr, BUN and β2MG in the intensive group and the conventional group showed a trend of increasing first and then decreasing with the time extension. The change range of the intensive group was smaller, There were significant differences between the two groups、time point and effect each other(P＜005). There was no significant difference in the incidence of CIN between the two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The intensive atorvastatin before operation combined with full hydration therapy protect the renal function of patients undergoing PCI surgery.


Study on the safety of coronary artery interventional therapy after coronary computed tomographic angiography

2017, 37(3):  266-269,305.  doi:10.3969/j.issn.10073205.2017.03.005

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［Abstract］ Objective〖HTSS〗〓The goal of this study was to investigate the effect on renal function in patients with coronary angiography or percutaneous coronary intervention(PCI)  after coronary CT angiography(CTA) within 1 week.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 384 patients underwent coronary angiography or angioplasty were enrolled into two groups:the test group 135 who were undergoing coronary angiography or angioplasty after coronary CTA within 1 week, and control group 249 who were undergoing coronary angiography only. Serum creatinine, cystatin C and the incidence of contrast induced nephropathy(CIN) were detected before procedure, after procedure 1 d, 2 d, 3 d.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There was no significant difference in serum creatinine, estimated glomerular filtration rate(eGFR), and cystatin C between groups before and after contrast exposure(P＞005). But there was significatnt difference between different point(P＜001). The study resulted in 16 cases of CIN, and there was no significant difference in the incidence of CIN between two groups(4.44% vs 4.02%, P＞005). The difference of PCI between the two groups was statistically significant(P＜001), and the PCI procedure in test group was significantly higher than that in control group(54.07% vs 33.33%).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓It is safe and feasible for patients with an eGFR≥60 mL·min-1·1.73 （m2)-1 to received coronary angiography or PCI after CTA within 1 week, and it has little impact on the renal function.


Therapeutic effect of human umbilical cord mesenchymal stem cells transplantation via peripheral vein in the treatment of hepatitis B liver cirrhosis#br#

ZHANG Sui， JIA Bei， GUO Cuimin, WANG Haifang, ZHOU Jing*

2017, 37(3):  270-273,330.  doi:10.3969/j.issn.10073205.2017.03.006

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［Abstract］  Objective〖HTSS〗〓To evaluate the curative effect of peripheral vein transplant human umbilical cord mesenchymal stem cells on patients with hepatitis B liver cirrhosis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty patients with hepatitis B liver cirrhosis were equally divided into treatment group and control group. The treatment group was given umbilical cord mesenchymal stem cell transplantation on the basis of comprehensive medical treatment and the control group was adapted with the comprehensive medical treatment. The changes of biochemical indexes, clinical symptoms and the occurrence of adverse reactions at 2, 4, 12 and 24 weeks before and after treatment were observed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After 4week treatment, the improvement rate of fatigue, abdominal distension, appetite and ascites in the treatment group were higher than that in the control group and the differences have statistical significance(P＜005). With time extension, alanine aminotransferase, aspartate aminotransferase and total bilirubin of the two groups were decreased, there was significant difference of time dissimilarity between two groups(P＜005), but there were no significant differences of interblock and interaction of interblock with time dissimilarity between two groups(P＞005). The albumin, cholinesterase and prothrombin activity showed an increasing trend and there were significant differences of time dissimilarity and interaction of interblock with time dissimilarity between two groups(P＜005), but there was no significant difference of interblock between two groups(P＞005). There were no suffered severe complications and adverse reactions in all groups.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Human umbilical cord mesenchymal stem cell transplantation via peripheral vein in the treatment of hepatitis B liver cirrhosis is safe and effective.


Correlation of level of serum soluble Eselectin with cognitive dysfunction in type 2 diabetes mellitus patients

ZHANG Xinxin1, FANG Hui2*, ZHEN Yanfeng2, XU Gang3, XU Jing2, ZHANG Dandan2

2017, 37(3):  274-277,310.  doi:10.3969/j.issn.10073205.2017.03.007

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［Abstract］ Objective〖HTSS〗〓To investigate the association of level of serum soluble Eselectin(sEselectin) with cognitive deficits in type 2 diabetes mellitus(T2DM) patients.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Enzymelinked immunosorbent assay is used to determine the sEselectin level in 80 cases of patients and 80 controls without T2DM from the Medical Examination Center. The data on demographic characteristics including age, gender, education, body mass index(BMI) and duration of illness were recored. Clinical parameters including highsensitivity Creactive protein(hsCRP), Homocysteine(Hcy), fasting plasma glucose(FPG), fasting serum lisulin(FIN), hemoglobin A1c(HbA1c), total cholesterol(TC), Triglycerides(TG), high density lipoprotein(HDLC), low density lipoprotein(LDLC) and homeostasis model assessmentinsulin resistance(HOMAIR) were collected. Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS) which consists of five subtests including immediate memory, visuospatial constructional, language, attention and delayed memory; and the scores from the above five subtests were scaled together to create a total score. Difference in RBANS scores was compared between the T2DM group and control group. T2DM patients were divided into high sEselectin level group and low sEselectin level group according to the median level of sEselectin, and the difference in cognitive function was compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Serum FPG, HbA1c,TC, TG, LDLC, hsCRP, Hcy, HOMAIR levels, BMI, and the level of sEselectin of the T2DM patients were higher than those of the controls(P＜005). RBANS scores were lower in the T2DM patients than in the controls on the total score and all subtests(P＜005) expect for constructional of RBANS. In the T2DM patients, immediate memory, visuospatial constructional, language, delayed memory and total score of the patients with low sEselectin were lower than those of the patients with high sEselectin(P＜005). In T2DM patients, sEselectin concentration was positively correlated with HOMAIR and negatively correlated with immediate memory, language, attention, delayed function and total score, the difference was statistically significant（P＜005）. 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓sEselectin may be involved in the occurrence and development of cognitive dysfunction in patients with T2DM patients.


Investigation and analysis of the nursing “knowledgebeliefpractice” condition on carrying out the preventive intervention in the 18 Thirdlevel GradeA hospitals #br#

ZHANG Xiuguo1, LI Haoru2, CHEN Caizhen1, LI Dongzheng3, ZHANG Li3, WEI Ning4*

2017, 37(3):  278-281,315.  doi:10.3969/j.issn.10073205.2017.03.008

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［Abstract］ Objective〖HTSS〗〓To investigate the present condition of the nursing service on carrying out preventive intervention for diabetes patients and to analyze the problems and the factors influencing preventive intervention, then to carry out the targeted preventive intervention of diabetes.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The interview outline and questionnaires were designed on the basis of the literature research and expert consultation. We choose 282 nurses in endocrinology with nurse practice certificate and voluntary cooperation from 18 general thirdlevel of Hebei province as the research objects by the unrandom sampling method.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The knowledge score of nurses was（5.68±1.13 ） points on average. There was a statistically significant(P＜005) difference of knowledge scores between the different education degree nurses, and the different professional titles nurses, among which the masters' average knowledge score and the association chief nurses were highest. The result of the variance analysis on knowledge score of nurses with different nursing work experience and different age showed statistically significant(P＜005). And with the increasing in education, age, title and length of work, the prevention knowledge score of nurses has the tendency to increase. The average selfassessment score of the function of preventive intervention of diabetes patients was（8.28±1.44 ） points, and the selfassessment score of the compliance of preventive intervention for diabetes patients was（5.07±1.39） points. From high to low the individualized directed for patients are having medication, drinking behavior, smoking behavior, health mission, the weight loss plan, exercise program, blood sugar monitoring programme, the weight loss plan and dietary therapy and psychogical counseling.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The awareness of nurses service for prophylactic intervention of diabetes was in good condition, and implemented guidance for the patient's health behavior, but there are still some weak points such as the grasping condition of preventive intervention knowledge was poor, the efforts of guidance was uneven, and the patient compliance was poor, which are the major influence factors of nursing work.


Clinical observation on three dimensional conformal radiotherapy combined with EGFRTKIs in the treatment of locally advanced nonsmall cell lung cancer

JIA Jinghao, WANG Jing, WANG Wei, YANG Haifang，YAO Xuemin， SUN Guogui

2017, 37(3):  282-286,320.  doi:10.3969/j.issn.10073205.2017.03.009

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［Abstract］ Objective〖HTSS〗〓To evaluate the effect of radiotherapy combined targeted therapy.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A retrospective analysis was performed on the medical records of 91 cases with locally advanced nonsmall cell lung cancer(NSCLC). The pathology was confirmed via histology and cytology, using three dimensional conformal radiation therapy or intensitymodulated radiation therapy, with 1.8-2.0 Gy per fraction once a day, five times a week and planning target volume 56-64 Gy. Thirtynine received radiotherapy alone. And 52 received radiotherapy combined with erlotinib. The KaplanMeier method was used to calculate overall survival rate. The Cox regression model was used for multivariate prognostic analysis.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓For all the patients, the survival rate of one, two and three years were 63.4%, 33.8%, and 17.0% respectively, and the median survival time was 19.4 months. Univariate analysis by Logrank test showed that the progress free survival and overall survival time varied significantly among lung cancer patients from different pathology type, gross target volume（GTV）, irradiation dose and epidermal growth factor rececptor（EGFR） mutation or nonmutation and receiving target therapy or nonreceiving target therapy(P＜005)，according to this research it indicated that lung cancer patient with squamous cell carcinoma, GTV less than 250 cm3, irradiation dose more than 60 Gy, EGFR mutation and receiving target therapy could survive a longer progress free survival and overall survival. Multiple factors analysis of Cox regression model suggested radiation dose, targeted therapy, the curative effect were the main factors for patients' survival time(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Radiation dose, target treatment and curative effect were prognostic factors of locally advanced NSCLC. Radiotherapy combined targeted therapy was an effective method for locally advanced NSCLC.


Fracture type, gender and age distribution of adult fractures at the base of the first metacarpal bone in Beijing, Tianjin and Hebei province

LIU Song, ZHANG Qi, CHEN Wei, ZHU Yanbin, LI Yansen, ZHANG Yingze*

2017, 37(3):  287-289,325.  doi:10.3969/j.issn.10073205.2017.03.010

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［Abstract］ Objective〖HTSS〗〓To investigate the fracture type, gender and age distribution of adult fractures at the base of the first metacarpal bone in Beijing, Tianjin and Hebei province.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓We retrospectively analyzed the clinical data of adult patients with fractures at the base of the first metacarpal bone who had been treated in Beijing, Tianjin and Hebei province. Analytic items included gender, age distribution and classification of fracture.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓A total of 367 cases were collected, with a male/female ratio of 5.12〖DK〗∶1. The median age was 40 years old. The peak age was youth group. There was significant difference in male/female ratio among different age groups（P＜005）. The male/female ratio of youth group was significantly higher than middleaged and elderly groups（P＜005）. There were no significant differences in gender and age distributions in different fracture types(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Young males had more fractures at the base of the first metacarpal bone. The peak ages of different fracture types were all youth group.


Application of painless management model in patients after total knee arthroplasty

HAN Xiangzhen， KANG Kai， GENG Qian， ZHANG Yunqing， LIU Han， DONG Jiangtao

2017, 37(3):  290-292,296.  doi:10.3969/j.issn.10073205.2017.03.011

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［Abstract］  Objective〖HTSS〗〓To explore the role of painless management in patients after total knee arthroplasty.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixtyeight patients with severe osteoarthritis were divided into two groups: observation group and control group, 34 cases in each group. They were calculated with clinical data, diagnosis and treatment, and prognosis.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Preoperative Lysholm score was no significant difference between the two groups. The Visual Analogue Scale(VAS) of the observation group before discharge was significantly lower than that of the control group, and the range of motion(ROM) of the observation group before discharge was better than that of the control group, the difference of VAS score and ROM was statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Multimode analgesia can effectively increase the awareness of preoperative active exercise through a series of postoperative rehabilitation methods. It can also reduce the rest and movement pain of patients after operation and ensure the success of postoperative rehabilitation plan and patient satisfaction.


The evaluation of liver function indices in infantile cholestatic hepatopathy

CHEN Yuan, MA Xueling, MA Suling， GENG Jianghui， ZHANG Shaodan

2017, 37(3):  293-296.  doi:10.3969/j.issn.10073205.2017.03.012

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［Abstract］ Objective〖HTSS〗〓To study the changes of liver function indices at initial phase and post treatment in infantile cholestatic hepatopathy(ICH) patients, and then to analyze the prognostic value of liver function indices to ICH.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The conditions of 86 infants with ICH were reviewed from pediatric department in the Second Hospital of Hebei Medical University. Serum liver function parameters were analyzed retrospectively to evaluate the diagnostic and prognostic significance of ICH.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Cytomegalovirus hepatitis and biliary atresia are the most main causes of ICH. The serum alanine aminotransferase levels of human cytomegalovirus hepatitis group and biliary atresia group at initial phase show no significant difference, while the serum γglutamyl transferase(γGGT) and total bilea cids(TBA) levels of these groups are statistically significant from the other. As to biliary atresia patients, serum total bilirubin affects TBA significantly.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓It is of great significance in serum liver function evaluation, especially serum γGGT and TBA levels in the diagnosis and the prognosis of patients with ICH.


Clinical observation of therapeutic effect of high intensity focused ultrasound and pharmacotherapy on perennial allergic rhinitis#br#

ZHANG Ming, REN Xiumin*, SHAN Chunguang, XU Ou, DONG Jinhui, WANG Jianxing

2017, 37(3):  297-300,335.  doi:10.3969/j.issn.10073205.2017.03.013

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［Abstract］ Objective〖HTSS〗〓To make a comparison between clinical therapeutic effect of highintensity focused ultrasound(HIFU) and pharmacotherapy on perennial allergic rhinitis(PAR) patients and to discuss the validity and superiority of HIFU on PAR.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The experiment data were randomly selected from 152 patients who had PAR, and they were divided into two groups under their own will. There are 72 patients in HIFU group and 80 patients in pharmacotherapy group. For the HIFU group, they were treated with HIFU assisted by nasal endoscope, with the bilateral inferior turbinate, the front of middle turbinate, agger nasi and the anterosuperior part of nasal septum scanned. As for the pharmacotherapy group, they were treated with conventional nasal spray hormone medicine and antihistamine medicine. There are 23 cases of HIFU group patients who voluntarily accept the saccharin test before and after the treatment, which is to detect the transmission function of nasal mucus cilia, the result of which will be further compared with normal group(non AR group).
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The curative effect of the pharmacotherapy group was higher than that of HIFU group at 1 weeks(P＜001). There was no significant difference between the 2 groups. After 6 months of treatment and treatment for 1 years, the effect of focused ultrasound group was better than that of drug treatment group(P<005 or ＜001). Following 1 year, HIFU group had 16 cases(22.2%), the pharmacotherapy group had 34 cases(42.5%), the recurrencerate of pharmacotherapy lower than of HIFU group, 2 groups was statistically significant difference on recurrence rate(P＜001). HIFU group began to gradually reduce the signs and symptoms score after 1 week, but the score increased again after 1 year. The symptoms and signs scores of pharmacotherapy group began to gradually reduce after 1 week , but on the 6 month, the scores began to rise , there was no statistically significant difference between the 2 group(P＞005). Two groups between point and group interaction  point have statistically significant (P＜001).The nasal cilia transmission time in HIFU is longer than the normal group before treatment(P＜001), but after 1 month and 1 year HIFU group on the nasal cilia transmission time is shorter than pretreatment (P＜001). And after 1 year the nasal cilia transmission time was longer than that in 1 month(P＜001).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓HIFU has better curative effect comparing with conventional pharmacotherapy and is worthy of clinical promotion.


Analysis of the clinical characteristics in children′s nasal bone fracture

ZHANG Pu, WANG Xin, GAO Haitao, ZHANG Xun, MU Junshang*

2017, 37(3):  301-305.  doi:10.3969/j.issn.10073205.2017.03.014

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［Abstract］ Objective〖HTSS〗〓To analyze the characteristics of nasal bone fracture in the pediatric population and to provide clinical basis for better prevention and treatment.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓We conducted a retrospective review on a series of 287 patients, 58(aged≤18 years) and 229(aged＞18 years), with nasal bone fracture who had been treated at our hospital. The following parameters were evaluated: sex, age, cause, monthly distribution and deviation of nasal septum. The children group were subdivided into preschool group(aged≤7 years), elementary school group(aged 8-14 years) and middle school group(aged 15-18 years).
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Compared to adults, nasal bone fracture was infrequent in pediatric population, and children′s nasal bone fractures were most occurred in middle school group. The numbers of man in each age group were higher than that of women as well as adults. Unlike the preschool group and elementary school group, the incidence of nasal bone fracture caused by violence was higher in middle school group and adult group. Nasal bone fractures in middle school group and Adult group were most commonly occurred in summer, and the other groups were lack of clear time distribution. Unlike the adult group, the deviation of nasal septum was less likely occurred in children.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Compared to adults, children′s nasal bone fracture has its own characteristics. Nasal bone fracture in the preschool group and elementary group chidren were lack of clear time distribution, but that in middle school group and ault group were most commonly occurred in june, september and december, and different ages have different characteristics. This study may be helpful in prevention and treatment.


Evaluation of the clinical effect of periodontal tissue regeneration combined with orthodontic treatment in patients with periodontitis

YU Aixia

2017, 37(3):  306-310.  doi:10.3969/j.issn.10073205.2017.03.015

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［Abstract］  Objective〖HTSS〗〓To analyze the clinical effect of periodontal tissue regeneration combined with orthodontic treatment and its effect on the recovery of oral function in patients with periodontitis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Eighty cases of patients with periodontitis were analyzed retrospectively. According to the random number table, all patients were divided into observation group and control group,40 cases in each. Patients in the two groups were treated with basic treatment,and then, patients in the control group were treated with periodontal tissue regeneration on the basis of routine treatment, while the patients in the observation group received periodontal tissue regeneration and orthodontic treatment on the basis of routine treatment.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The total clinical effective rate of the observation group was significantly higher than that of the control group, and the clinical effect was also better than that of control group(P＜005). The plaque index(PLI), gingival index(GI), bleeding on probing(BOP), sulcus bleeding index(SBI), pocket depth(PD) and clinical attachment(CAL) of patients in the two groups after treatment were significantly lower than that before treatment(P＜005). The PLI, GI, BOP, SBI, and PD in the observation group after treatment were significantly lower than that in the control group(P＜005). There was no significant difference in the periodontal index of CAL of the two groups after treatment(P＞005). After the treatment, the tooth mobility was significantly better than that before treatment of the two groups(P＜005),but there was no significant difference between the two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Periodontal tissue regeneration combined with orthodontic treatment in patients with periodontitis can significantly improve the clinical symptoms of periodontitis and periodontal index of patients, also can promote the comprehensive recovery of oral cavity. It is worthy of being widely used.


The application value of ultrasonic elastosonography for differential diagnosis of hysteromyoma and adenomyoma#br#

ZHANG Luping1,2, LIU Weiwei1, GUOYanjing1, WANG Jing1, WEN Xiaoduo1, YANGYi1*

2017, 37(3):  311-315.  doi:10.3969/j.issn.10073205.2017.03.016

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［Abstract］ Objective〖HTSS〗〓To compare the sensitivity, specificity, accuracy rate, positive predictive value, negative of conventional ultrasonography and elasticity point quantification(ElastPQ) technique  in the differential diagnosis of hysteromyoma and  adenomyoma， and to find out the quantitative criteria.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and twentyone paitients with mass in uterus and 98 normal people were underwent both conventional ultrasonography and elasticity point quantification technique detection. Two kinds of diagnostic methods were evaluated, and the quantitative elasticity imaging technique was used to identify the cutoff value of hysteromyoma and adenomyoma.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The sensitivity of ElastPQ was lower than conventional ultrasonography while the specificity, accuracy rate, positive predictive value were higher. Compared with the  normal people，ElastPQ  value of hysteromyoma were higher while  adenomyoma were  lower. The ElastPQ  value among  hysteromyoma, adenomyoma and normal uterus had significant difference(P＜005). The best cutoff value of differentiate hysteromyoma and adenomyoma was 14.03 kPa.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓ElastPQ technique can help differentiate hysteromyoma from adenomyoma by offering quantitative criteria for stiffness of tissue.


Correlation between ultrasonic sign and the expression level of Ki67 and P120ctn in patients with breast cancer

TU Jinjing， ZHANG Xin, LIU Qing

2017, 37(3):  316-320.  doi:10.3969/j.issn.10073205.2017.03.017

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［Abstract］ Objective〖HTSS〗〓To investigate the effect of P120ctn and Ki67 expression on breast cancer ultrasonography.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The breast cancer tissues of 124 patients with breast cancer who were examined and treated in our hospital. Analysis of the relevant biological samples was in accordance with the standard of diagnosis and treatment of breast cancer. The ultrasonic features of all the samples were analyzed, such as the edge, size, shape, calcification, lymph node metastasis, blood flow imaging and so on. The expression level of Ki67 and P120ctn in tissue samples was detected by immunohistochemical method, and their correlation with the ultrasonic features of breast cancer were analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The expression of Ki67 in breast cancer tissues was positive, and the expression of P120ctn in breast cancer tissues was negative. There was no significant difference in the expression levels of P120ctn and Ki67 between the tissues with different diameters and edges(P＞005). However, the expression of P120ctn and Ki67 were significantly different in the tissues with different shape, different distribution of microcalcifications, different blood flow imaging grade and lymph node metastasis(P＜005). The expression of P120ctn protein and Ki67 protein was related to the shape of the tumor, the distribution of micro calcification, the grade of blood flow imaging and the characteristics of lymph node metastasis. The expression of P120ctn and Ki67 were negatively correlated(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The results showed that there was a certain relationship between ultrasonic signs and the expression of P120ctn protein and Ki67 protein. Ultrasonographic signs can be used as noninvasive prediction of the expression of P120ctn and Ki67 protein in patients with breast cancer to provide more evidence for the degree of malignancy and prognosis of breast cancer.


Effects of different anesthesia methods on the concentration of melatonin in elderly patients with gastric cancer and its correlation with emergence delirium

ZHENG Jun1， HAN Wen2*

2017, 37(3):  321-325.  doi:10.3969/j.issn.10073205.2017.03.018

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［Abstract］  Objective〖HTSS〗〓To investigate the influence of combined epidural and general anesthesia in elderly patients to concentrations of melatonin and its correlation with emergence delirium.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty elderly patients undergoing gastric cancer surgery were divided into epidural anesthesia compound general anesthesia(ET) group and general anesthesia(T) group, 30 patients each. The ET group was given epidural anesthesia, 15 min later, both groups were treated with general anesthesia. Melatonin concentration, cognitive function score and postoperative restlessness score were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The urine volume, general anesthetic propofol dosage of ET group were less than T group, as well as recovery time, waking time, breathing time, extubation time of ET group were less than T group(P＜005). The melatonin concentration increased between two groups, and the ET group increased more. And among groups, different time pionts and at different time points between groups, the difference was statistically significant(P＜005). The minimental state examinatlon score of the two groups showed a trend of decreasing first and then increasing, the change of ET group was smaller, and the difference between the two groups was statistically significant(P＜005). The agitation score of recovery period in ET group was significantly lower than that in T group(P＜005). There was a negative correlation between the agitation score of recovery period and the concentration of melatonin, melatonin changes and body weight(P＜005), and was positively correlated with the amount of urine, the time of recovery and the amount of propofol(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Epidural anesthesia combines the advantages of general anesthesia and epidural anesthesia, had analgesia both in intraoperative and postoperative, can stable hemodynamics, reduce the amount of anesthetic, maintain postoperative plasma fade melanin concentration, reduce postoperative restlessness, shorten hospital stay and improve prognosis. It is worthy of clinical promotion.


Calcitonin gene related peptide participate in the regulation of Th17 and Treg differentiation

LIU Wenxuan1, YANG Lei1, LIU Wencong2, YAO Zhiyan3, LI Tao1, SU Peng4*

2017, 37(3):  326-330.  doi:10.3969/j.issn.10073205.2017.03.019

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［Abstract］ Objective〖HTSS〗〓To dissect the role of calcitonin gene related peptide(CGRP) on IL17 producing T cell(Th17) and regulatory T cell(Treg) differentiation.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Naive CD4+T cells were isolated from human peripheral blood by magnetic activated cell sorting(MACS) selection, and cultured under Th17polarizing and Tregpolarizing condition, The proportion of Th17 cells and Treg cells were detected by flow cytometry, the relative expression levels of retionidrelated orphan nuclear receptor γt(RORγt) mRNA and foxhead box protein 3(FoxP3) mRNA were measured by realtime RTPCR. In addition, we detected the production of IL17A by enzymelinked immunosorbent assay, we explored the effects of CGRP on the differentiation of Th17 and Treg cells form Several aspects.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓CGRP increased the proportion of Th17 cells and the expression of RORγt mRNA(P＜005). Additionally, CGRP also increased the production of IL17A(P＜005), these effects of CGRP were in dosedependent manner. Meanwhile, CGRP inhibited the percentage of Treg cells and the expression of FoxP3 mRNA also in dosedependent way(P＜005), peaking at 10-6 M.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓These results demonstrate that CGRP facilitates naive CD4+T cells from human peripheral blood differentiate to Th17 cells, but suppresses them differentiate to Treg cells.


Determination of contents of praeruptorin A and praeruptorin B in Peucedani Radix by high performance liquid chromatography

TIAN Yulu, WANG Hongxia, GAO Meng, ZHAO Lili, ZHANG Lantong, WANG Qiao*

2017, 37(3):  331-335.  doi:10.3969/j.issn.10073205.2017.03.020

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［Abstract］  Objective〖HTSS〗〓To improve the method for the determination of praeruptorin A and praeruptorin B in Peucedani Radix by high performance liquid chromatography. Then the method was used for the analysis of commercial “Qian Hu”.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Methanol was used as the extraction solvent and ultrasonic extraction time was 30 min. The extract was analyzed directly. The separation was performed on a Thermo ODS HYPERSIL(4.6×250 mm, 5 μm) column using methanol and water(68〖DK〗∶32) as mobile phase.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The methodology validation presented that praeruptorin A and praeruptorin B were in good correlation in the range of 5.00-400.00 mg/L and 0.50-40.00 mg/L with the regression equations of Y=28.478 222 4X+6.484 094（r=0.999 99） and Y=25.589 318 7X-0.328 822（r=0.999 99）, respectively. The results of the precision (RSD) and recoveries were in the range of 0.6%-2.0% and 90.7%-104.8%, respectively. Nine batches of commercial “Qian Hu” were determined by the established method.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The method is simpler, more rapid and more reproducible. It can be used for the accurate determination of praeruptorin A and praeruptorin B in Peucedani Radix.