M型钾离子通道开放剂对心肺复苏大鼠心肌的保护作用

doi:10.3969/j.issn.10073205.2017.10.003

河北医科大学学报

M型钾离子通道开放剂对心肺复苏大鼠心肌的保护作用

1.华北理工大学附属医院神经内科重症病房，河北唐山 063000；2.河北省保定市第七医院重症医学科，河北保定 072150；
3.中国人民解放军国际和平医院急诊科，河北石家庄 050082

出版日期:2017-10-25 发布日期:2017-10-18
作者简介:王瑞刚(1974-)，男，河北正定人，华北理工大学附属医院主任医师,副教授，医学硕士，从事神经内科疾病诊治研究。

Protective effect of M type potassium channel opener in myocardium of cardiopulmonary resuscitation rats#br#

1.Department of Neurology Intensive Care Units, Affiliated Hospital of North China University of Science
and Technology, Hebei Province, Tangshan 063000， China；2 .Department of Intensive Medicine, the
Seventh Hospital of Baoding, Hebei Province, Baoding 072150， China；3.Department of
Emergency, Bethune Internation Peace Hospital of PLA, Shijiazhuang 050082， China

Online:2017-10-25 Published:2017-10-18

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨M型钾离子通道开放剂对心肺复苏大鼠心肌的保护作用。
〖HTH〗方法〖HTSS〗〖KG*2〗将健康Wistar大鼠60只采用随机数字表法分为假手术组(A组)、心脏骤停复苏组（B组）、M型钾离子通道开放剂干预组（C组）各20只，按心肺复苏后自主循环恢复6 h、12 h、24 h、48 h、72 h，每组分别处死大鼠4只，采集心肌标本，检测心肌指标（超氧化物歧化酶、丙二醛、心肌肌钙蛋白T），并观察心脏结构（左心室容积、心室间隔厚度）。
〖HTH〗结果〖HTSS〗〖KG*2〗组间比较：B组在所有时点超氧化物歧化酶较A组降低，C组较B组升高，差异均有统计学意义(P＜005)；组内比较：B组和C组在12 h、24 h逐渐下降，48 h和72 h逐渐升高，差异均有统计学意义(P＜005)。组间比较：B组在所有时点心肌丙二醛、心肌肌钙蛋白T、左心室容积、心室间厚度较A组升高，C组只有24 h心室间厚度高于A组，差异均有统计学意义(P＜005)；组内比较：B组和C组心肌丙二醛、心肌肌钙蛋白、C组的左心室容积在12 h、24 h逐渐升高，48 h和72 h逐渐下降，差异均有统计学意义(P＜005)。
〖HTH〗结论〖HTSS〗〖KG*2〗M型钾离子通道开放剂可减轻心肺复苏大鼠的心肌损伤，具有良好的心肌保护作用。

关键词: 心肺复苏术, M型钾离子通道开放剂, 大鼠

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the protective effect of Mtype potassium channel opening agent on myocardium of cardiopulmonary resuscitation rats.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 60 healthy Wistar rats were randomly divided into sham operation group(group A), cardiac resuscitation group(group B), Mtype potassium channel opener intervention group(group C), and there were 20 rats in each group. Four rats were sacrificed in each group at 6 h, 12 h, 24 h, 48 h and 72 h after cardiopulmonary resuscitation recovery. The myocardium samples were collected, the myocardial parameters(superoxide dismutase, malondialdehyde, cardiac troponin T) were detected, and the cardiac structure(left ventricular volume, ventricular septal thickness) were observed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Compared with group A, the levels of superoxide dismutase at any time point in group B were all lower, and those in group C were higher than group B , the difference were significant(P＜005). Both in group B and in group C, the levels of superoxide dismutase at 12 h and 24 h were all decreased gradually, but were increased at 48 h and 72 h, and the difference were significant(P＜005). The levels of malondialdehyde , cardiac troponin T, left ventricular volume, and ventricular tachycardia at any time point in group B were higher than those in group A, and those in group C were lower than group B. The ventricular septal thickness of group C was thicker than that of group A 24 h after operation. Both in group B and in group C, the levels of malondialdehyde and cardiac troponin T at 12 h and 24 h were increased gradually, but were decreased at 48 h and 72 h. And the left ventricular volume were the same changes in group C. The difference were significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Mtype potassium channel opener can protect myocardial cells and reduce the impairment on myocardial of cardiopulmonary resuscitation rats.

Key words: cardiopulmonary resuscitation； M type potassium channel opener, rats

王瑞刚1，赵春香1，李月兰2，齐海涛2，张〓磊3，石秋艳1. M型钾离子通道开放剂对心肺复苏大鼠心肌的保护作用[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2017.10.003.

WANG Ruigang1, ZHAO Chunxiang1, LI Yuelan2, QI Haitao2, ZHANG Lei3, SHI Qiuyan1. Protective effect of M type potassium channel opener in myocardium of cardiopulmonary resuscitation rats#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2017.10.003.

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M型钾离子通道开放剂对心肺复苏大鼠心肌的保护作用

Protective effect of M type potassium channel opener in myocardium of cardiopulmonary resuscitation rats#br#

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