河北医科大学学报 ›› 2024, Vol. 45 ›› Issue (3): 303-307.doi: 10.3969/j.issn.1007-3205.2024.03.009

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宫颈癌患者FBXO22表达与HPV基因型和病理组织检查结果的相关性分析

  

  1. 河北省沧州市人民医院妇科，河北 沧州 061002

  • 出版日期:2024-03-25 发布日期:2024-04-07
  • 作者简介:黄新瑞（1986-），女，河北沧州人，河北省沧州市人民医院主管护师，医学学士，从事妇科疾病护理研究。
  • 基金资助:
    河北省医学科学研究课题计划（20232092）

Correlation analysis of FBXO22 expression with HPV genotype and histopathologic findings in patients with cervical cancer

  1. Department of Gynecology, Cangzhou People′s Hospital, Hebei Province, Cangzhou 061002, China

  • Online:2024-03-25 Published:2024-04-07

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摘要： 目的 探究宫颈癌患者F-box only protein 22（FBXO22）表达与人乳头瘤病毒(human papilloma virus,HPV）基因型和病理组织检查结果的相关性。
方法 选择宫颈癌患者108例，进行HPV检验，并对其进行HPV基因分型，免疫组织化学检测FBXO22蛋白表达情况，Spearman 秩相关分析评价指标间相关性。运用受试者工作特征（receiver operating characteristic，ROC）曲线评估诊断效能。
结果 高危型HPV患者FBXO22阳性表达率为91.67%，低危型HPV患者FBXO22阳性表达率为69.44%，高危型HPV组FBXO22阳性表达率高于低危型HPV组(P＜0.05)。随着鳞癌Ⅰ期到Ⅳ期增加，FBXO22阳性表达率随之增加(P＜0.05)，随着分化程度增加，FBXO22阳性表达率随之减少(P＜0.05)。高危型和低危型HPV感染与FBXO22蛋白水平呈现正相关（r=0.859、0.704，P=0.005、0.009)。分化程度和临床分期与FBXO22蛋白水平均呈现正相关（r=0.884、0.873，P=0.002、0.003)。ROC曲线分析结果显示FBXO22蛋白联合hrHPV DNA检的特异度和AUC面积分别为89.23%和0.823，明显高于单独指标检测(P＜0.001)。
结论 宫颈癌患者FBXO22表达与高危型HPV感染密切相关，并且可反映宫颈癌患者的分化程度和临床分期。FBXO22与高危型HPV两者联合检测用于早期防治宫颈癌具有重要意义。


关键词: 宫颈肿瘤, FBXO22, 乳头状瘤病毒科

Abstract: Objective To explore the correlation between the expression of F-box only protein 22 (FBXO22) and human papilloma virus (HPV) genotypes and pathological findings in patients with cervical cancer. 
Methods A total of 108 patients with cervical cancer were selected for HPV test, and HPV genotyping was performed. The expression of FBXO22 protein was detected by immunohistochemistry, and correlation among indicators was evaluated by Spearman rank correlation analysis. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic performance. 
Results The positive expression rate of FBXO22 was 91.67% in high-risk HPV patients and 69.44% in low-risk HPV patients. The positive expression rate of FBXO22 in the high-risk HPV group was higher than that in the low-risk HPV group (P＜0.05). With an increase in the number of stages Ⅰ to Ⅳ of squamous cell carcinoma, the positive expression rate of FBXO22 also increased (P＜0.05). With the increase in the degree of differentiation, the positive expression rate of FBXO22 decreased (P＜0.05). There was a positive correlation between high-risk and low-risk HPV infection and FBXO22 protein levels (r=0.859, 0.704, P=0.005, 0.009). The degree of differentiation and clinical stage were positively correlated with FBXO22 protein levels (r=0.884, 0.873, P=0.002, 0.003). The ROC curve analysis results showed that the specificity and the area under the ROC curve (AUC) of FBXO22 protein combined with hrHPV DNA detection were 89.23% and 0.823%, respectively, which were significantly higher than those detected by each indicator alone (P＜0.001). 
Conclusion The expression of FBXO22 in cervical cancer patients is closely related to high-risk HPV infection, and also reflects the differentiation degree and clinical stage of cervical cancer patients. The combined detection of FBXO22 and high-risk HPV is of great significance for the early prevention and treatment of cervical cancer.


Key words: uterine cervical neoplasms, FBXO22, papillomaviridae

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