河北医科大学学报

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采用MRI T2*值定量评估腰椎骨质疏松的价值#br#

  

  1. 河北医科大学第三医院放射科，河北 石家庄 050051
  • 出版日期:2019-05-25 发布日期:2019-05-22
  • 作者简介:张晓飞（1989-），女，河北邯郸人，河北医科大学第三医院医学硕士研究生，从事医学影像诊断研究。
  • 基金资助:
    河北省科技计划项目（16277701D）

Quantitative evaluation of lumber vertebra osteoporosis with MRI T2* mapping#br#

  1. Department of Radiology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
  • Online:2019-05-25 Published:2019-05-22

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨采用MRI T2* 值定量评估腰椎骨质疏松的临床应用价值。
〖HTH〗方法〖HTSS〗〖KG*2〗对87例绝经后老年女性进行腰椎常规（T1WI及T2WI）序列、T2*mapping序列扫描及定量CT骨密度（bone mineral density，BMD）检查，分别测量L2~L4椎体的T2*值及L2~L4椎体的BMD值。以BMD值为金标准，将检测椎体分入骨质疏松、骨量减少、骨量正常3组中，对测量的T2*值及BMD值进行Spearman相关性分析，使用受试者工作特征（receiver operating characteristic curve，ROC）曲线分析T2*值诊断腰椎骨质疏松和骨量减少的敏感度、特异度等。
〖HTH〗结果〖HTSS〗〖KG*2〗骨量正常、骨量减少、骨质疏松   3组T2*值与BMD值均呈负相关（rs=-0.47、-0.52、-0.57，P＜005）。ROC曲线显示T2*值诊断腰椎椎体骨量减少及骨质疏松的ROC曲线下面积分别为0.76、0.79，取截断值12.48时其诊断骨量减少的敏感度为82.2%、特异度为59.3%，取截断值17.13时其诊断骨质疏松的敏感度为87.1%、特异度为56.2%。
〖HTH〗结论〖HTSS〗〖KG*2〗MRI T2*mapping序列可无创性定量反映腰椎椎体骨质密度并对骨质疏松程度作出评价，具有临床应用价值。

关键词: 骨质疏松, 绝经后, 骨密度, 诊断显像

Abstract: 〗［Abstract］ Objective〖HTSS〗〓To explore the clinical value of MRI T2* values for quantitative evaluation of the lumbar vertebrae osteoporosis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The patients who underwent the routine lumbar MRI scan, T2* mapping scan and quantitative computer tomography(QCT) were collected. Bone mineral density(BMD) of the QCT were obtained, and T2* values of L2-L4 were measured by two independent observers. According to the BMD values, the vertebral bodies were divided into the normal group, the osteopenia group and the osteoporosis group. The correlations of T2* values and BMD were analyzed with Spearman correlation tests. The diagnostic efficiency of T2* values was evaluated by receiver operating characteristic curve(ROC curve).
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The correlations of the T2* values and BMD values in all three groups were negative(rs=-0.47, -0.52, -0.57, P＜0.05 respectively). The areas under ROC curve of T2* value for diagnosis of the lumber vertebral osteopenia and osteoporosis were 0.76 and 0.79, respectively. The diagnosis sensitivity was 82.2% and the specificity was 59.3% for diagnosis of osteopenia at the threshold of 12.48, 87.1% and 56.2% for the diagnosis of osteoporosis at the threshold of 17.13.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The MRI T2* mapping sequence could be a reliable diagnostic indicator for quantitative evaluation of the lumbar vertebrae osteoporosis．

Key words: osteoporosis, postmenopausal, bone density, diagnostic imaging

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