重组人粒细胞巨噬细胞集落刺激因子凝胶联合功能敷料序贯治疗中厚皮供皮区创面的临床观察

doi:10.3969/j.issn.1007-3205.2021.05.013

河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (5): 555-558,581.doi: 10.3969/j.issn.1007-3205.2021.05.013

重组人粒细胞巨噬细胞集落刺激因子凝胶联合功能敷料序贯治疗中厚皮供皮区创面的临床观察

1.四川省达州市中心医院整形美容烧伤科，四川达州 635000；2.四川省宣汉县人民医院检验科，四川宣汉 636150

出版日期:2021-05-25 发布日期:2021-05-28
作者简介:陈剑利（1988-）,男,四川宣汉人，四川省达州市中心医院主治医师，医学硕士，从事整形美容烧伤研究。
基金资助:
达州市科技计划项目（18ZDYF0014）

Clinical observation of recombinant human granulocyte macrophage colony stimulating factor gel combined with functional dressing for sequential treatment of medium-thickness skin donor site wounds

1. Department of Plastic Surgery, Dazhou Central Hospital, Sichuan Province, Dazhou 635000, China;
2.Department of Laboratory, Xuanhan People's Hospital, Sichuan Province，Xuanhan 636150, China

Online:2021-05-25 Published:2021-05-28

摘要/Abstract

摘要： 目的观察重组人粒细胞巨噬细胞集落刺激因子（recombinant human granulocyte macrophage colony stimulating factor，rhGM-CSF）凝胶联合功能敷料序贯治疗中厚皮供皮区创面的临床运用。
方法将78例取中厚皮片的患者随机分为试验组和对照组。试验组供皮区采用rhGM-CSF凝胶并在术后第2天联合藻酸盐敷料、脂质水胶体敷料修复创面。对照组采用传统凡士林油纱、术后第2无菌敷料覆盖修复创面，对比2组患者术后创面感染情况、换药疼痛评分、创面换药次数及舒适度、创面愈合时间、创面愈合效果。
结果 ①试验组愈合时间、换药次数均低于对照组（P＜0.05）；②试验组换药疼痛分级显著低于对照组（P＜0.05）；③试验组患者舒适度、创面愈合质量均高于对照组，护理难度及创面感染率均低于对照组（P＜0.05）。
结论 rhGM-CSF凝胶联合藻酸盐、脂质水胶体敷料用于中厚皮片供皮区创面，能降低创面感染率、减轻痛苦，提高舒适度并提升创面愈合质量，临床疗效理想。

关键词: 粒细胞巨噬细胞集落刺激因子, 敷料, 水胶体, 治疗结果

Abstract: Objective To observe the clinical application of recombinant human granulocyte macrophage colony stimulating factor(rhGM-CSF) gel combined with functional dressings for sequential treatment of medium-thickness skin donor site wounds.
Methods A total of 78 patients with medium-thickness skin grafts were randomly divided into experimental group and control group. The skin donor area of the experimental group was treated with rhGM-CSF gel, and combined with alginate dressing and lipid hydrocolloid dressing to repair the wound on the second day after surgery. The control group used traditional petroleum jelly gauze and sterile dressing on the second postoperative day to cover and repair the wound. The postoperative wound infection, dressing change pain score, wound dressing frequency and comfort, wound healing time, and wound healing effect were compared between two groups.
Results ①The healing time and the number of dressing changes in the experimental group were shorter or lower than those in the control group(P＜0.05). ②The pain grade of dressing change in the experimental group was significantly lower than that in the control group(P＜0.05). ③The patient comfort and wound healing quality of the experimental group were higher than those in the control group, while nursing difficulty and wound infection rate were lower than those of control group(P＜0.05).
Conclusion The rhGM-CSF gel combined with alginate and lipid hydrocolloid dressings can be used on the wound surface of the medium-thickness skin donor site, which can reduce the infection rate of the wound surface, alleviate the pain, improve the comfort and the quality of wound healing, and the clinical effect is ideal.

Key words: granulocyte-macrophage colony-stimulating factor, dressings, hydrocolloid, treatment outcome

陈剑利, 李贵宣, 蒋亮, 李磊. 重组人粒细胞巨噬细胞集落刺激因子凝胶联合功能敷料序贯治疗中厚皮供皮区创面的临床观察[J]. 河北医科大学学报, 2021, 42(5): 555-558,581.

CHEN Jian-li, LI Gui-xuan, JIANG Liang, LI Lei. Clinical observation of recombinant human granulocyte macrophage colony stimulating factor gel combined with functional dressing for sequential treatment of medium-thickness skin donor site wounds[J]. Journal of Hebei Medical University, 2021, 42(5): 555-558,581.

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重组人粒细胞巨噬细胞集落刺激因子凝胶联合功能敷料序贯治疗中厚皮供皮区创面的临床观察

Clinical observation of recombinant human granulocyte macrophage colony stimulating factor gel combined with functional dressing for sequential treatment of medium-thickness skin donor site wounds

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