河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (3): 344-347,354.doi: 10.3969/j.issn.1007-3205.2021.03.020

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无症状高尿酸血症患者血尿酸浓度分层与血脂、血糖的关系

  

  1. 1.河北省衡水市卫生健康委员会综合监督执法局，河北 衡水 053000；2.河北省河北医科大学第二医院检验科，
    河北 石家庄 050000；3.河北省衡水市哈励逊国际和平医院检验科，河北 衡水 053000
  • 出版日期:2021-03-25 发布日期:2021-04-02
  • 作者简介:于同芳（1969-），男，河北景县人，河北省衡水市卫生健康委员会综合监督执法局副主任医师，医学学士，从事传染病防治、医疗服务等研究。

Relationship between serum uric acid concentration and blood lipids, blood glucose in patients with asymptomatic hyperuricemia

  1. 1.The Supervision and Enforcement Institute of Muncipal Health Commission of Hengshui, Hebei Province,
    Hengshui 053000, China； 2.Department of Clinical Laboratory, the Second Hospital of Hebei Medical
    University, Shijiazhuang 050000, China； 3.Department of Clinical Laboratory, Hengshui
    Harrison Intelnational Peace Hospital， Hebei Province, Hengshui 053000, China
  • Online:2021-03-25 Published:2021-04-02

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摘要： 目的  探讨无症状高尿酸血症患者随着尿酸分层程度的升高，血尿酸（uric acid，UA）水平与血脂、血糖的关系。
方法  选取正常体检人群4 918例，其中男性2 741例，女性2 177例，首先依据UA浓度以60 μmol/L为组距，直接分组，将男性体检人群分为四组，女性体检人群分为三组，分析不同组别患者血脂指标［三酯甘油(triglyceride，TG)、总胆固醇(total cholesterol，TC)、高密度脂蛋白(high-density lipoprotein，HDL)、低密度脂蛋白(low-density lipoprotein，LDL)）与血糖（blood glucose，GLU）］之间的差异，分析血UA浓度与血脂、血糖关系；其次考虑到年龄对女性UA浓度的影响，以49岁为分界点进行初步分组后，再依据UA浓度将女性患者进行分组，49岁以下女性分为二组，49岁以上女性分为三组，分析不同组别患者血脂指标与血糖之间的差异。
结果  女性人群随着UA升高，其GLU、TG、TC明显升高并且UA浓度越高这些指标也越高，HDL降低并且UA浓度越高其值越低；男性患者随着UA浓度升高，TG也随着平行升高，另外随着UA浓度的升高男性患者LDL、TC升高，HDL降低。49岁以下女性随着UA升高，GLU、TG、TC、LDL明显升高，HDL降低；49岁以上女性，随着UA浓度升高，TG明显升高，HDL降低，并与UA浓度相关，随着UA浓度的升高患者GLU、TC升高。
结论  随着UA浓度的升高，患者血糖、血脂明显升高，提示机体代谢可能存在障碍，UA升高与血糖、血脂可能互相影响。

关键词: 高尿酸血症, 尿酸, 血糖

Abstract: Objective  To investigate the relationship between serum uric acid(SUA) concentration and blood lipids, blood glucose in patients with asymptomatic hyperuricemia, with an increase in SUA concentration.
Methods  A total of 4 918 patients were selected, including 2 741 males and 2 177 females. The concentration of SUA at 60 μmol/L was set as the cut-off value for grouping. According to the concentration of SUA, the males and females who underwent physical examination were divided into four groups and three groups respectively. The differences in blood lipid［triglyceride(TG), total cholesterol(TC), high-density lipoprotein(HDL), low-density lipoprotein(LDL)］ and glucose(GLU) were analyzed in different groups. The relationship between SUA concentration and blood lipid, blood glucose was analyzed. Considering the effect of age on SUA concentration of women, the age of 49 years was set as a cut-off value for initial grouping. According to SUA concentration, all women were grouped, women under the age of 49 were divided into two groups and women over the age of 49 were divided into three groups. The differences in the blood lipids and blood glucose in the patients from different groups were analyzed.
Results  In the females, the GLU, TG, and TC were significantly increased with high SUA concentration, and the higher the concentration of SUA, the higher indicators were obtained. HDL was decreased with an increase in SUA concentration. In the males, TG was also increased in parallel with SUA concentration. In addition, GLU and TC were increased, while HDL was decreased in patients with an increase in SUA concentration. In women under the age of 49 years, GLU, TG, TC, and LDL were increased significantly and HDL was decreased in patients with an increase in SUA concentration. In women over the age of 49, with an increase in SUA concentration, TG was also increased significantly and HDL was decreased. An increase in SUA concentration led to increased GLU and TC.
Conclusion  With the increase of the SUA concentration, the blood glucose and blood lipid were increased obviously, suggesting metabolic dysfunction of the body. An increase in SUA concentration, blood glucose and blood lipid may affect each other.

Key words: hyperuricemia； uric acid, blood glucose

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