Abstract: ［Abstract］ Objective〖HTSS〗To investigate the effect of Eptifibatide combined with Prostaglandin E1 on myocardial microcirculation in patients with acute ST-segment elevation myocardial infarction(STEMI) after primary percutaneous coronary intervention(pPCI).
 〖WTHZ〗Methods〖HTSS〗A total of 162 patients with acute STEMI were randomly divided into the control group(n=81) and the observation group(n=81). All patients were given Prostaglandin E1 intravenously 30 minutes before surgery and maintained for 7 days. In the observation group, the intracoronary artery was treated with Eptifibatide, and the postoperative venous duration was 18 hours. Thrombolysis in myocardial infarction(TIMI), corrected TIMI frame count(cTFC), ST-segment resolution(STR) rate of ECG, creatine kinase-MB(CK-MB), cardiac troponin I(cTnI), left ventricular ejection fraction(LVEF), and wall motion score index(WMSI) were measured before and after pPCI. Myocardial contrast echocardiography was performed 48 hours and 1 week after surgery, respectively.
 〖WTHZ〗Results〖HTSS〗There was no statistical difference in basic clinical data, coronary angiography data and interventional data between two groups(P＞0.05). The cTFC frames, CK-MB and cTnI peaks in the observation group after pPCI were significantly lower than those in the control group(P＜0.05). However, the postoperative TIMI grade 3 blood flow, the decrease of electrocardiogram STR after 90min, the local myocardial blood flow 48 hours after the operation and 1 week after the operation, and the cardiac color doppler ultrasound LVEF were significantly increased compared with the control group(P＜0.05).
 〖WTHZ〗Conclusion〖HTSS〗Eptifibatide combined with Prostaglandin E1 can effectively improve the myocardial perfusion of acute STEMI and myocardial function.

Key words: myocardial infarction, angioplasty, balloon, coronary, alprostadil